The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Arabidopsis Mitogen-Activated Protein Kinase Kinases MKK1 and MKK2 Have Overlapping Functions in Defense Signaling Mediated by MEKK1, MPK4, and MKS1
Open accessAbstract
The Arabidopsis (Arabidopsis thaliana) MKK1 and MKK2 mitogen-activated protein kinase kinases have been implicated in biotic and abiotic stress responses as part of a signaling cascade including MEKK1 and MPK4. Here, the double loss-of-function mutant (mkk1/2) of MKK1 and MKK2 is shown to have marked phenotypes in development and disease resistance similar to those of the single mekk1 and mpk4 mutants. Because mkk1 or mkk2 single mutants appear wild type, basal levels of MPK4 activity are not impaired in them, and MKK1 and MKK2 are in part functionally redundant in unchallenged plants. These findings are confirmed and extended by biochemical and molecular analyses implicating the kinases in jasmonate- and salicylate-dependent defense responses, mediated in part via the MPK4 substrate MKS1. In addition, transcriptome analyses delineate overlapping and specific effects of the kinases on global gene expression patterns demonstrating both redundant and unique functions for MKK1 and MKK2.
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Cites
Cytoscape: A software Environment for integrated models of biomolecular interaction networks
Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., Amin, N., Schwikowski, B., & Ideker, T. (2003) · Genome Research · doi:10.1101/gr.1239303 · Cited by 51,888
Cited by
MAPK Cascades in Plant Disease Resistance Signaling
Meng, X., & Zhang, S. (2013) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-082712-102314 · Cited by 1,367
Signaling Mechanisms in Pattern-Triggered Immunity (PTI)
Bigeard, J., Colcombet, J., & Hirt, H. (2015) · Molecular Plant · doi:10.1016/j.molp.2014.12.022 · Cited by 1,105
Mitogen-Activated Protein Kinase Signaling in Plants
Cristina, M., Petersen, M., & Mundy, J. (2010) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042809-112252 · Cited by 1,103
Self-citationThe role of ABA and MAPK signaling pathways in plant abiotic stress responses
Danquah, A., de Zelicourt, A., Colcombet, J., & Hirt, H. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.09.006 · Cited by 755
MAPK cascade signalling networks in plant defence
Pitzschke, A., Schikora, A., & Hirt, H. (2009) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2009.06.008 · Cited by 710
Metadata
- Authors
- Qiu, J.-L., Zhou, L., Yun, B.-W., Nielsen, H. B., Fiil, B. K., Petersen, K., MacKinlay, J., Loake, G. J., Mundy, J., & Morris, P. C.
- Venue
- Plant Physiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-07-03
- Volume
- 148
- Issue
- 1
- Pages
- 212-222
- ISSN
- 0032-0889 (ISSN-L)
- 1532-2548
- OpenAlex
- W2017784972
- Cited by
- 316
- References
- 1
- FWCI
- 21.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Qiu, J.-L., Zhou, L., Yun, B.-W., Nielsen, H. B., Fiil, B. K., Petersen, K., MacKinlay, J., Loake, G. J., Mundy, J., & Morris, P. C. (2008). Arabidopsis Mitogen-Activated Protein Kinase Kinases MKK1 and MKK2 Have Overlapping Functions in Defense Signaling Mediated by MEKK1, MPK4, and MKS1. Plant Physiology. https://doi.org/10.1104/pp.108.120006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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