A Mechanistic Link between STM and CUC1 during Arabidopsis Development
Open accessAbstract
The KNOXI transcription factor SHOOT MERISTEMLESS (STM) is required to establish and maintain the Arabidopsis (Arabidopsis thaliana) apical meristem, yet little is known about its direct targets. Using different approaches we demonstrate that the induction of STM causes a significant up-regulation of the organ boundary gene CUP SHAPED COTYLEDON1 (CUC1), which is specific and independent of other meristem regulators. We further show that the regulation of CUC1 by STM is direct and identify putative binding sites in its promoter. Continuous expression of STM in Arabidopsis leaf primordia also causes the activation of CUC2-3, as well as microRNA MIR164a, which provides a negative feedback loop by posttranscriptionally regulating CUC1 and CUC2. The results bring new insights into the mechanistic links between KNOXI and CUC transcription factors and contribute to the understanding of the regulatory network controlled by STM.
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CUC1, CUC2, and CUC3 have redundant functions in meristem formation.
“Tissue markers of the boundary zone are the Arabidopsis NAM-ATAF1/2-CUC2 (NAC) transcription factors CUP SHAPED COTYLEDONS1, 2, and 3 (CUC1, 2, and 3; Spinelli et al., 2011) that have redundant functions in meristem formation.”
From Shaping plant architecture (2015) · cites this paper as Spinelli et al., 2011
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References 60 · Cited by 145
- Authors
- Spinelli, S. V., Martin, A. P., Viola, I. L., Gonzalez, D. H., & Palatnik, J. F.
- Affiliations
- Universidad Nacional del Litoral (AR)
- Instituto de Biología Molecular y Celular de Rosario, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina (S.V.S., A.P.M., J.F.P.); Instituto de Agrobiotecnología del Litoral, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, CC 242 Paraje El Pozo, 3000 Santa Fe, Argentina (I.L.V., D.H.G.)
- Corresponding author
- Palatnik, Javier F.
- Venue
- Plant Physiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-08-01
- Volume
- 156
- Issue
- 4
- Pages
- 1894-1904
- ISSN
- 0032-0889 (ISSN-L)
- 1532-2548
- PMC
- PMC3149926
- OpenAlex
- W2076378697
- Cited by
- 145
- References
- 60
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 15 · 2023: 9 · 2022: 15 · 2021: 9 · 2020: 13 · 2019: 8 · 2018: 5 · 2017: 5 · 2016: 7 · 2015: 11 · 2014: 6 · 2013: 11 · 2012: 9
- FWCI
- 10.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- PLANT PHYSIOLOGY (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Greater South Information System
- Funders
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Parasitism and Resistance
- Keywords
- SHOOT MERISTEMLESS, apical meristem, transcriptional regulation, promoter binding sites, post-transcriptional regulation, negative feedback loop, leaf primordia, Arabidopsis thaliana
- MeSH terms
- Base Sequence, Molecular Sequence Data, Promoter Regions, Genetic, Protein Binding, Arabidopsis, Homeodomain Proteins, Gene Expression Regulation, Plant, Genome, Plant, Feedback, Physiological, Arabidopsis Proteins, MicroRNAs
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