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Export of Salicylic Acid from the Chloroplast Requires the Multidrug and Toxin Extrusion-Like Transporter EDS5
Open accessAbstract
Salicylic acid (SA) is central for the defense of plants to pathogens and abiotic stress. SA is synthesized in chloroplasts from chorismic acid by an isochorismate synthase (ICS1); SA biosynthesis is negatively regulated by autoinhibitory feedback at ICS1. Genetic studies indicated that the multidrug and toxin extrusion transporter ENHANCED DISEASE SUSCEPTIBILITY5 (EDS5) of Arabidopsis (Arabidopsis thaliana) is necessary for SA accumulation after biotic and abiotic stress, but so far it is not understood how EDS5 controls the biosynthesis of SA. Here, we show that EDS5 colocalizes with a marker of the chloroplast envelope and that EDS5 functions as a multidrug and toxin extrusion-like transporter in the export of SA from the chloroplast to the cytoplasm in Arabidopsis, where it controls the innate immune response. The location at the chloroplast envelope supports a model of the effect of EDS5 on SA biosynthesis: in the eds5 mutant, stress-induced SA is trapped in the chloroplast and inhibits its own accumulation by autoinhibitory feedback.
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Citations
Cites
Salicylic acid, a multifaceted hormone to combat disease
Vlot, A. C., Dempsey, D. A., & Klessig, D. F. (2009) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.050908.135202 · Cited by 2,568
Cited by
Stories of Salicylic Acid: A Plant Defense Hormone
Ding, P., & Ding, Y. (2020) · Trends in Plant Science · doi:10.1016/j.tplants.2020.01.004 · Cited by 743
Salicylic Acid: Biosynthesis and Signaling
Peng, Y., Yang, J., Li, X., & Zhang, Y. (2021) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-081320-092855 · Cited by 560
Transcriptional networks in plant immunity
Tsuda, K., & Somssich, I. E. (2015) · New Phytologist · doi:10.1111/nph.13286 · Cited by 552
Isochorismate-derived biosynthesis of the plant stress hormone salicylic acid
Rekhter, D., Lüdke, D., Ding, Y., Feussner, K., Zienkiewicz, K., Lipka, V., Wiermer, M., Zhang, Y., & Feussner, I. (2019) · Science · doi:10.1126/science.aaw1720 · Cited by 468
ChIP-seq reveals broad roles of SARD1 and CBP60g in regulating plant immunity
Sun, T., Zhang, Y., Li, Y., Zhang, Q., Ding, Y., & Zhang, Y. (2015) · Nature Communications · doi:10.1038/ncomms10159 · Cited by 284
Metadata
- Authors
- Serrano, M., Wang, B., Aryal, B., Garcion, C., Abou-Mansour, E., Heck, S., Geisler, M., Mauch, F., Nawrath, C., & Métraux, J.-P.
- Venue
- Plant Physiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-06-13
- Volume
- 162
- Issue
- 4
- Pages
- 1815-1821
- ISSN
- 0032-0889 (ISSN-L)
- 1532-2548
- OpenAlex
- W2114780353
- Cited by
- 233
- References
- 1
- FWCI
- 19.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Serrano, M., Wang, B., Aryal, B., Garcion, C., Abou-Mansour, E., Heck, S., Geisler, M., Mauch, F., Nawrath, C., & Métraux, J.-P. (2013). Export of Salicylic Acid from the Chloroplast Requires the Multidrug and Toxin Extrusion-Like Transporter EDS5. Plant Physiology. https://doi.org/10.1104/pp.113.218156
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