The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Functional Analysis of Cyclin-Dependent Kinase Inhibitors of Arabidopsis
Open accessAbstract
Cyclin-dependent kinase inhibitors, such as the mammalian p27(Kip1) protein, regulate correct cell cycle progression and the integration of developmental signals with the core cell cycle machinery. These inhibitors have been described in plants, but their function remains unresolved. We have isolated seven genes from Arabidopsis that encode proteins with distant sequence homology with p27(Kip1), designated Kip-related proteins (KRPs). The KRPs were characterized by their domain organization and transcript profiles. With the exception of KRP5, all presented the same cyclin-dependent kinase binding specificity. When overproduced, KRP2 dramatically inhibited cell cycle progression in leaf primordia cells without affecting the temporal pattern of cell division and differentiation. Mature transgenic leaves were serrated and consisted of enlarged cells. Although the ploidy levels in young leaves were unaffected, endoreduplication was suppressed in older leaves. We conclude that KRP2 exerts a plant growth inhibitory activity by reducing cell proliferation in leaves, but, in contrast to its mammalian counterparts, it may not control the timing of cell cycle exit and differentiation.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
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New functional activities for the p21 family of CDK inhibitors.
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“Not only are the cyclin D/CDK4 complexes inert toward the inhibitory function of the Kip/Cip proteins, but their activation is stimulated by the CKIs (Cheng et al., 1999).”
BackgroundInfluentialCell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1
Luo, Y., Hurwitz, J., & Massagué, J. (1995) · Nature · doi:10.1038/375159a0 · Cited by 549
Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA
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“Kip/Cip family members are reported to interact with many other regulatory proteins, including the proliferating cell nuclear antigen (Chen et al., 1995), the coactivator of c-Jun JAB1 (Tomoda et al., 1999), and the syntaxin-like molecule CARB (McShea et al., 2000).”
Background
Cited by
Genome-wide analysis of core cell cycle genes in Arabidopsis
Vandepoele, K., Raes, J., De Veylder, L., Rouzé, P., Rombauts, S., & Inzé, D. (2002) · The Plant Cell · doi:10.1105/tpc.010445 · Cited by 594
Self-citationBrassinosteroids control meristem size by promoting cell cycle progression in Arabidopsis roots
González-García, M.-P., Vilarrasa-Blasi, J., Zhiponova, M., Divol, F., Mora-García, S., Russinova, E., & Caño-Delgado, A. I. (2011) · Development · doi:10.1242/dev.057331 · Cited by 522
The RETINOBLASTOMA-RELATED Gene Regulates Stem Cell Maintenance in Arabidopsis Roots
Wildwater, M., Campilho, A., Perez-Perez, J. M., Heidstra, R., Blilou, I., Korthout, H., Chatterjee, J., Mariconti, L., Gruissem, W., & Scheres, B. (2005) · Cell · doi:10.1016/j.cell.2005.09.042 · Cited by 395
Synchronous Arabidopsis suspension cultures for analysis of cell‐cycle gene activity
Menges, M., & Murray, J. A. H. (2002) · The Plant Journal · doi:10.1046/j.1365-313x.2002.01274.x · Cited by 332
Alonso-Peral, M. M., Li, J., Li, Y., Allen, R. S., Schnippenkoetter, W., Ohms, S., White, R. G., & Millar, A. A. (2010) · Plant Physiology · doi:10.1104/pp.110.160630 · Cited by 313
Metadata
- Authors
- De Veylder, L., Beeckman, T., Beemster, G. T. S., Krols, L., Terras, F., Landrieu, I., Van Der Schueren, E., Maes, S., Naudts, M., & Inzé, D.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-07
- Volume
- 13
- Issue
- 7
- Pages
- 1653-1668
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2142192445
- Cited by
- 640
- References
- 5
- FWCI
- 37.08
- Type
- journal article
- Language
- en
- Open access
- green
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- De Veylder, L., Beeckman, T., Beemster, G. T. S., Krols, L., Terras, F., Landrieu, I., Van Der Schueren, E., Maes, S., Naudts, M., & Inzé, D. (2001). Functional Analysis of Cyclin-Dependent Kinase Inhibitors of Arabidopsis. The Plant Cell. https://doi.org/10.1105/tpc.010087
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