The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Activation Tagging in Tomato Identifies a Transcriptional Regulator of Anthocyanin Biosynthesis, Modification, and Transport
Open accessAbstract
We have developed a high-throughput T-DNA insertional mutagenesis program in tomato using activation tagging to identify genes that regulate metabolic pathways. One of the activation-tagged insertion lines (ant1) showed intense purple pigmentation from the very early stage of shoot formation in culture, reflecting activation of the biosynthetic pathway leading to anthocyanin accumulation. The purple coloration resulted from the overexpression of a gene that encodes a MYB transcription factor. Vegetative tissues of ant1 plants displayed intense purple color, and the fruit showed purple spotting on the epidermis and pericarp. The gene-to-trait relationship of ant1 was confirmed by the overexpression of ANT1 in transgenic tomato and in tobacco under the control of a constitutive promoter. Suppression subtractive hybridization and RNA hybridization analysis of the purple tomato plants indicated that the overexpression of ANT1 caused the upregulation of genes that encode proteins in both the early and later steps of anthocyanidin biosynthesis as well as genes involved in the glycosylation and transport of anthocyanins into the vacuole.
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Cites
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302
Cited by
Flavonoids: a colorful model for the regulation and evolution of biochemical pathways
Koes, R., Verweij, W., & Quattrocchio, F. (2005) · Trends in Plant Science · doi:10.1016/j.tplants.2005.03.002 · Cited by 1,640
Butelli, E., Titta, L., Giorgio, M., Mock, H.-P., Matros, A., Peterek, S., Schijlen, E. G. W. M., Hall, R. D., Bovy, A. G., Luo, J., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt.1506 · Cited by 1,238
Tohge, T., Nishiyama, Y., Hirai, M. Y., Yano, M., Nakajima, J., Awazuhara, M., Inoue, E., Takahashi, H., Goodenowe, D. B., Kitayama, M., et al. (2005) · The Plant Journal · doi:10.1111/j.1365-313x.2005.02371.x · Cited by 985
Recent advances on the regulation of anthocyanin synthesis in reproductive organs
Petroni, K., & Tonelli, C. (2011) · Plant Science · doi:10.1016/j.plantsci.2011.05.009 · Cited by 935
Lin-Wang, K., Bolitho, K., Grafton, K., Kortstee, A., Karunairetnam, S., McGhie, T. K., Espley, R. V., Hellens, R. P., & Allan, A. C. (2010) · BMC Plant Biology · doi:10.1186/1471-2229-10-50 · Cited by 699
Metadata
- Authors
- Mathews, H., Clendennen, S. K., Caldwell, C. G., Liu, X. L., Connors, K., Matheis, N., Schuster, D. K., Menasco, D. J., Wagoner, W., Lightner, J., & Wagner, D. R.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-07-14
- Volume
- 15
- Issue
- 8
- Pages
- 1689-1703
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2118305958
- Cited by
- 525
- References
- 1
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- green
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