The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Mutation of the TGD1 Chloroplast Envelope Protein Affects Phosphatidate Metabolism in Arabidopsis
Abstract
Phosphatidate (PA) is a central metabolite of lipid metabolism and a signaling molecule in many eukaryotes, including plants. Mutations in a permease-like protein, TRIGALACTOSYLDIACYLGLYCEROL1 (TGD1), in Arabidopsis thaliana caused the accumulation of triacylglycerols, oligogalactolipids, and PA. Chloroplast lipids were altered in their fatty acid composition consistent with an impairment of lipid trafficking from the endoplasmic reticulum (ER) to the chloroplast and a disruption of thylakoid lipid biosynthesis from ER-derived precursors. The process mediated by TGD1 appears to be essential as mutation of the protein caused a high incidence of embryo abortion. Isolated tgd1 mutant chloroplasts showed a decreased ability to incorporate PA into galactolipids. The TGD1 protein was localized to the inner chloroplast envelope and appears to be a component of a lipid transporter. As even partial disruption of TGD1 function has drastic consequences on central lipid metabolism, the tgd1 mutant provides a tool to explore regulatory mechanisms governing lipid homeostasis and lipid trafficking in plants.
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Citations
Cites
Ohlrogge, J., & Browse, J. (1995) · The Plant Cell · doi:10.1105/tpc.7.7.957 · Cited by 1,492 · cited 3×
“The biosynthesis of TAGs draws from intermediates of phospholipid metabolism, such as PA or PC (Ohlrogge and Browse, 1995).”
BackgroundInfluentialAuxin-resistant mutants of Arabidopsis thaliana with an altered morphology
Estelle, M. A., & Somerville, C. (1987) · Molecular and General Genetics MGG · doi:10.1007/bf00333575 · Cited by 576
Cited by
Kang, J., Park, J., Choi, H., Burla, B., Kretzschmar, T., Lee, Y., & Martinoia, E. (2011) · The Arabidopsis Book · doi:10.1199/tab.0153 · Cited by 573
The evolution, metabolism and functions of the apicoplast
Lim, L., & McFadden, G. I. (2010) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2009.0273 · Cited by 356
Vanhercke, T., El Tahchy, A., Liu, Q., Zhou, X., Shrestha, P., Divi, U. K., Ral, J., Mansour, M. P., Nichols, P. D., James, C. N., et al. (2014) · Plant Biotechnology Journal · doi:10.1111/pbi.12131 · Cited by 323
(2024) · doi:10.1093/plphys/kiae274 · Cited by 25
Metadata
- Authors
- Xu, C., Fan, J., Froehlich, J. E., Awai, K., & Benning, C.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-09-30
- Volume
- 17
- Issue
- 11
- Pages
- 3094-3110
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2162305308
- Cited by
- 221
- References
- 2
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Xu, C., Fan, J., Froehlich, J. E., Awai, K., & Benning, C. (2005). Mutation of the TGD1 Chloroplast Envelope Protein Affects Phosphatidate Metabolism in Arabidopsis. The Plant Cell. https://doi.org/10.1105/tpc.105.035592
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