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Arabidopsis Protein Kinase PKS5 Inhibits the Plasma Membrane H+-ATPase by Preventing Interaction with 14-3-3 Protein
Open accessAbstract
Regulation of the trans-plasma membrane pH gradient is an important part of plant responses to several hormonal and environmental cues, including auxin, blue light, and fungal elicitors. However, little is known about the signaling components that mediate this regulation. Here, we report that an Arabidopsis thaliana Ser/Thr protein kinase, PKS5, is a negative regulator of the plasma membrane proton pump (PM H+ -ATPase). Loss-of-function pks5 mutant plants are more tolerant of high external pH due to extrusion of protons to the extracellular space. PKS5 phosphorylates the PM H+ -ATPase AHA2 at a novel site, Ser-931, in the C-terminal regulatory domain. Phosphorylation at this site inhibits interaction between the PM H+ -ATPase and an activating 14-3-3 protein in a yeast expression system. We show that PKS5 interacts with the calcium binding protein SCaBP1 and that high external pH can trigger an increase in the concentration of cytosolic-free calcium. These results suggest that PKS5 is part of a calcium-signaling pathway mediating PM H+ -ATPase regulation.
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Citations
Cited by
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Yang, Y., & Guo, Y. (2018) · New Phytologist · doi:10.1111/nph.14920 · Cited by 1,631
Self-citationShabala, S., & Pottosin, I. (2014) · Physiologia Plantarum · doi:10.1111/ppl.12165 · Cited by 720
Self-citationInsights into plant salt stress signaling and tolerance
Zhou, H., Shi, H., Yang, Y., Feng, X., Chen, X., Xiao, F., Lin, H., & Guo, Y. (2024) · Journal of Genetics and Genomics · doi:10.1016/j.jgg.2023.08.007 · Cited by 677
Self-citationDissecting iron deficiency‐induced proton extrusion in Arabidopsis roots
Santi, S., & Schmidt, W. (2009) · New Phytologist · doi:10.1111/j.1469-8137.2009.02908.x · Cited by 616
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Metadata
- Authors
- Fuglsang, A. T., Guo, Y., Cuin, T. A., Qiu, Q., Song, C., Kristiansen, K. A., Bych, K., Schulz, A., Shabala, S., Schumaker, K. S., Palmgren, M. G., & Zhu, J.-K.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-05
- Volume
- 19
- Issue
- 5
- Pages
- 1617-1634
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2119670501
- Cited by
- 446
- References
- 0
- FWCI
- 21.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Arabidopsis Protein Kinase PKS5 Inhibits the Plasma Membrane H+-ATPase by Preventing Interaction with 14-3-3 Protein. https://app.cochat.ai/papers/10.1105/tpc.105.035626
- The paper
- Fuglsang, A. T., Guo, Y., Cuin, T. A., Qiu, Q., Song, C., Kristiansen, K. A., Bych, K., Schulz, A., Shabala, S., Schumaker, K. S., Palmgren, M. G., & Zhu, J.-K. (2007). Arabidopsis Protein Kinase PKS5 Inhibits the Plasma Membrane H+-ATPase by Preventing Interaction with 14-3-3 Protein. The Plant Cell. https://doi.org/10.1105/tpc.105.035626
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