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Analysis of the Transcription Factor WUSCHEL and Its Functional Homologue in Antirrhinum Reveals a Potential Mechanism for Their Roles in Meristem Maintenance
Open accessAbstract
One of the most significant features of plant development is the way in which it can be elaborated and modulated throughout the life of the plant, an ability that is conferred by meristems. The Arabidopsis thaliana WUSCHEL gene (WUS), which encodes a homeodomain transcription factor, is required to maintain the stem cells in the shoot apical meristem in an undifferentiated state. The mechanism by which WUS prevents the differentiation of stem cells is unknown. We have characterized a meristem maintenance mutant in Antirrhinum majus and shown that it arises from a defect in the WUS orthologue ROSULATA (ROA). Detailed characterization of a semidominant roa allele revealed an essential role for the conserved C-terminal domain. Expression of either ROA or WUS lacking this domain causes a failure of meristem maintenance. The conserved domain mediates an interaction between WUS and two members of a small family of corepressor-like proteins in Arabidopsis. Our results suggest that WUS functions by recruiting transcriptional corepressors to repress target genes that promote differentiation, thereby ensuring stem cell maintenance.
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Cited by
Evidence for Network Evolution in an Arabidopsis Interactome Map
Arabidopsis Interactome Mapping Consortium, Dreze, M., Carvunis, A.-R., Charloteaux, B., Galli, M., Pevzner, S. J., Tasan, M., Ahn, Y.-Y., Balumuri, P., Barabási, A.-L., et al. (2011) · Science · doi:10.1126/science.1203877 · Cited by 893
The WUS homeobox-containing (WOX) protein family
van der Graaff, E., Laux, T., & Rensing, S. A. (2009) · Genome Biology · doi:10.1186/gb-2009-10-12-248 · Cited by 455
Self-citationPi, L., Aichinger, E., van der Graaff, E., Llavata-Peris, C. I., Weijers, D., Hennig, L., Groot, E., & Laux, T. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.04.024 · Cited by 379
Self-citationTwenty years on: The inner workings of the shoot apical meristem, a developmental dynamo
Barton, M. K. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2009.11.029 · Cited by 372
Ikeda, M., Mitsuda, N., & Ohme-Takagi, M. (2009) · The Plant Cell · doi:10.1105/tpc.109.069997 · Cited by 355
Metadata
- Authors
- Kieffer, M., Stern, Y., Cook, H., Clerici, E., Maulbetsch, C., Laux, T., & Davies, B.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-02-03
- Volume
- 18
- Issue
- 3
- Pages
- 560-573
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2146078553
- Cited by
- 229
- References
- 0
- FWCI
- 17.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Analysis of the Transcription Factor WUSCHEL and Its Functional Homologue in Antirrhinum Reveals a Potential Mechanism for Their Roles in Meristem Maintenance. https://app.cochat.ai/papers/10.1105/tpc.105.039107
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- Kieffer, M., Stern, Y., Cook, H., Clerici, E., Maulbetsch, C., Laux, T., & Davies, B. (2006). Analysis of the Transcription Factor WUSCHEL and Its Functional Homologue in Antirrhinum Reveals a Potential Mechanism for Their Roles in Meristem Maintenance. The Plant Cell. https://doi.org/10.1105/tpc.105.039107
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