The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Identification of the 2-Hydroxyglutarate and Isovaleryl-CoA Dehydrogenases as Alternative Electron Donors Linking Lysine Catabolism to the Electron Transport Chain of Arabidopsis Mitochondria
Open accessAbstract
The process of dark-induced senescence in plants is relatively poorly understood, but a functional electron-transfer flavoprotein/electron-transfer flavoprotein:ubiquinone oxidoreductase (ETF/ETFQO) complex, which supports respiration during carbon starvation, has recently been identified. Here, we studied the responses of Arabidopsis thaliana mutants deficient in the expression of isovaleryl-CoA dehydrogenase and 2-hydroxyglutarate dehydrogenase to extended darkness and other environmental stresses. Evaluations of the mutant phenotypes following carbon starvation induced by extended darkness identify similarities to those exhibited by mutants of the ETF/ETFQO complex. Metabolic profiling and isotope tracer experimentation revealed that isovaleryl-CoA dehydrogenase is involved in degradation of the branched-chain amino acids, phytol, and Lys, while 2-hydroxyglutarate dehydrogenase is involved exclusively in Lys degradation. These results suggest that isovaleryl-CoA dehydrogenase is the more critical for alternative respiration and that a series of enzymes, including 2-hydroxyglutarate dehydrogenase, plays a role in Lys degradation. Both physiological and metabolic phenotypes of the isovaleryl-CoA dehydrogenase and 2-hydroxyglutarate dehydrogenase mutants were not as severe as those observed for mutants of the ETF/ETFQO complex, indicating some functional redundancy of the enzymes within the process. Our results aid in the elucidation of the pathway of plant Lys catabolism and demonstrate that both isovaleryl-CoA dehydrogenase and 2-hydroxyglutarate dehydrogenase act as electron donors to the ubiquinol pool via an ETF/ETFQO-mediated route.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Floral dip: a simplified method forAgrobacterium‐mediated transformation ofArabidopsis thaliana
Clough, S. J., & Bent, A. F. (1998) · The Plant Journal · doi:10.1046/j.1365-313x.1998.00343.x · Cited by 21,934
Porra, R. J., Thompson, W. A., & Kriedemann, P. E. (1989) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(89)80347-0 · Cited by 5,992
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., et al. (2009) · Nature · doi:10.1038/nature08617 · Cited by 4,154
GATEWAY™ vectors for Agrobacterium-mediated plant transformation
Karimi, M., Inzé, D., & Depicker, A. (2002) · Trends in Plant Science · doi:10.1016/s1360-1385(02)02251-3 · Cited by 3,635
Gas chromatography mass spectrometry–based metabolite profiling in plants
Lisec, J., Schauer, N., Kopka, J., Willmitzer, L., & Fernie, A. R. (2006) · Nature Protocols · doi:10.1038/nprot.2006.59 · Cited by 2,170
Self-citationLim, P. O., Kim, H. J., & Gil Nam, H. (2007) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.57.032905.105316 · Cited by 1,978
GMD@CSB.DB: the Golm Metabolome Database
Kopka, J., Schauer, N., Krueger, S., Birkemeyer, C., Usadel, B., Bergmuller, E., Dormann, P., Weckwerth, W., Gibon, Y., Stitt, M., et al. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bti236 · Cited by 1,382
Self-citationGABA in plants: just a metabolite?
Bouché, N., & Fromm, H. (2004) · Trends in Plant Science · doi:10.1016/j.tplants.2004.01.006 · Cited by 1,154
Buchanan‐Wollaston, V., Page, T., Harrison, E., Breeze, E., Lim, P. O., Nam, H. G., Lin, J., Wu, S., Swidzinski, J., Ishizaki, K., et al. (2005) · The Plant Journal · doi:10.1111/j.1365-313x.2005.02399.x · Cited by 1,063
Self-citation
Cited by
Protein degradation – an alternative respiratory substrate for stressed plants
Araújo, W. L., Tohge, T., Ishizaki, K., Leaver, C. J., & Fernie, A. R. (2011) · Trends in Plant Science · doi:10.1016/j.tplants.2011.05.008 · Cited by 438
Self-citationThe Regulation of Essential Amino Acid Synthesis and Accumulation in Plants
Galili, G., Amir, R., & Fernie, A. R. (2016) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-043015-112213 · Cited by 422
Self-citationAutophagy, plant senescence, and nutrient recycling
Avila-Ospina, L., Moison, M., Yoshimoto, K., & Masclaux-Daubresse, C. (2014) · Journal of Experimental Botany · doi:10.1093/jxb/eru039 · Cited by 369
Watanabe, M., Balazadeh, S., Tohge, T., Erban, A., Giavalisco, P., Kopka, J., Mueller-Roeber, B., Fernie, A. R., & Hoefgen, R. (2013) · Plant Physiology · doi:10.1104/pp.113.217380 · Cited by 320
Self-citationThe evolution of phenylpropanoid metabolism in the green lineage
Tohge, T., Watanabe, M., Hoefgen, R., & Fernie, A. R. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2012.758083 · Cited by 296
Self-citation
Metadata
- Authors
- Araújo, W. L., Ishizaki, K., Nunes-Nesi, A., Larson, T. R., Tohge, T., Krahnert, I., Witt, S., Obata, T., Schauer, N., Graham, I. A., Leaver, C. J., & Fernie, A. R.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-05-01
- Volume
- 22
- Issue
- 5
- Pages
- 1549-1563
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2100999167
- Cited by
- 340
- References
- 51
- FWCI
- 6.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Identification of the 2-Hydroxyglutarate and Isovaleryl-CoA Dehydrogenases as Alternative Electron Donors Linking Lysine Catabolism to the Electron Transport Chain of Arabidopsis Mitochondria. https://app.cochat.ai/papers/10.1105/tpc.110.075630
- The paper
- Araújo, W. L., Ishizaki, K., Nunes-Nesi, A., Larson, T. R., Tohge, T., Krahnert, I., Witt, S., Obata, T., Schauer, N., Graham, I. A., Leaver, C. J., & Fernie, A. R. (2010). Identification of the 2-Hydroxyglutarate and Isovaleryl-CoA Dehydrogenases as Alternative Electron Donors Linking Lysine Catabolism to the Electron Transport Chain of Arabidopsis Mitochondria. The Plant Cell. https://doi.org/10.1105/tpc.110.075630
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
