The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Evidence for a SAL1-PAP Chloroplast Retrograde Pathway That Functions in Drought and High Light Signaling in Arabidopsis
Open accessAbstract
Compartmentation of the eukaryotic cell requires a complex set of subcellular messages, including multiple retrograde signals from the chloroplast and mitochondria to the nucleus, to regulate gene expression. Here, we propose that one such signal is a phosphonucleotide (3′-phosphoadenosine 5′-phosphate [PAP]), which accumulates in Arabidopsis thaliana in response to drought and high light (HL) stress and that the enzyme SAL1 regulates its levels by dephosphorylating PAP to AMP. SAL1 accumulates in chloroplasts and mitochondria but not in the cytosol. sal1 mutants accumulate 20-fold more PAP without a marked change in inositol phosphate levels, demonstrating that PAP is a primary in vivo substrate. Significantly, transgenic targeting of SAL1 to either the nucleus or chloroplast of sal1 mutants lowers the total PAP levels and expression of the HL-inducible ASCORBATE PEROXIDASE2 gene. This indicates that PAP must be able to move between cellular compartments. The mode of action for PAP could be inhibition of 5′ to 3′ exoribonucleases (XRNs), as SAL1 and the nuclear XRNs modulate the expression of a similar subset of HL and drought-inducible genes, sal1 mutants accumulate XRN substrates, and PAP can inhibit yeast (Saccharomyces cerevisiae) XRNs. We propose a SAL1-PAP retrograde pathway that can alter nuclear gene expression during HL and drought stress.
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Cites
Microarray data analysis: from disarray to consolidation and consensus
Allison, D. B., Cui, X., Page, G. P., & Sabripour, M. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1749 · Cited by 1,339 · cited 1×
“Cyber-T employs a mixture model-basedmethod described by Allison et al. (2006) for the computation of the global false-positive and false-negative levels inherent in a DNA microarray experiment.”
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Mittler, R., Zandalinas, S. I., Fichman, Y., & Van Breusegem, F. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00499-2 · Cited by 2,351
The Role of the Plant Antioxidant System in Drought Tolerance
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Action mechanisms of small microbial volatile compounds in plants
Gámez-Arcas, S., Baroja-Fernández, E., García-Gómez, P., Muñoz, F. J., Almagro, G., Bahaji, A., Sánchez-López, Á. M., & Pozueta-Romero, J. (2022) · Journal of Experimental Botany · doi:10.1093/jxb/erab463 · Cited by 33
Metadata
- Authors
- Estavillo, G. M., Crisp, P. A., Pornsiriwong, W., Wirtz, M., Collinge, D., Carrie, C., Giraud, E., Whelan, J., David, P., Javot, H., Brearley, C., Hell, R., Marin, E., & Pogson, B. J.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-11-01
- Volume
- 23
- Issue
- 11
- Pages
- 3992-4012
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2118155608
- Cited by
- 553
- References
- 1
- FWCI
- 12.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Estavillo, G. M., Crisp, P. A., Pornsiriwong, W., Wirtz, M., Collinge, D., Carrie, C., Giraud, E., Whelan, J., David, P., Javot, H., Brearley, C., Hell, R., Marin, E., & Pogson, B. J. (2011). Evidence for a SAL1-PAP Chloroplast Retrograde Pathway That Functions in Drought and High Light Signaling in Arabidopsis. The Plant Cell. https://doi.org/10.1105/tpc.111.091033
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