NODULE ROOT and COCHLEATA Maintain Nodule Development and Are Legume Orthologs of Arabidopsis BLADE-ON-PETIOLE Genes
Open accessAbstract
During their symbiotic interaction with rhizobia, legume plants develop symbiosis-specific organs on their roots, called nodules, that house nitrogen-fixing bacteria. The molecular mechanisms governing the identity and maintenance of these organs are unknown. Using Medicago truncatula nodule root (noot) mutants and pea (Pisum sativum) cochleata (coch) mutants, which are characterized by the abnormal development of roots from the nodule, we identified the NOOT and COCH genes as being necessary for the robust maintenance of nodule identity throughout the nodule developmental program. NOOT and COCH are Arabidopsis thaliana BLADE-ON-PETIOLE orthologs, and we have shown that their functions in leaf and flower development are conserved in M. truncatula and pea. The identification of these two genes defines a clade in the BTB/POZ-ankyrin domain proteins that shares conserved functions in eudicot organ development and suggests that NOOT and COCH were recruited to repress root identity in the legume symbiotic organ.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
BOP1/2 orthologous genes NOOT and COCH from M. truncatula and Pisum sativum have the same functions as BOP genes in Arabidopsis.
“Indeed, BOP1/2 orthologous genes NODULE ROOT (NOOT) and COCHLEATA (COCH), from M. truncatula and Pisum sativum (pea), respectively, have the same functions as BOP genes in Arabidopsis (Couzigou et al., 2012).”
From <i>Divide et impera</i>: boundaries shape the plant body and initiate new meristems (2016) · cites this paper as Couzigou et al., 2012
NOOT in Medicago truncatula, COCH in pea, and Cul4 in barley are homologous to Arabidopsis BOP1-2.
“| BOP1-2 | NOOT (medicago (Medicago | BTB/ | Fused inflorescences, simpler | SAM and leaf primordia, | Ha et al. (2004, 2007); Norberg et al. |”
From <i>Divide et impera</i>: boundaries shape the plant body and initiate new meristems (2016) · cites this paper as Couzigou et al. (2012)
Cites
BLADE-ON-PETIOLE–Dependent Signaling Controls Leaf and Floral Patterning in Arabidopsis
Hepworth, S. R., Zhang, Y., McKim, S., Li, X., & Haughn, G. W. (2005) · The Plant Cell · doi:10.1105/tpc.104.030536 · Cited by 351 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
<i>Divide et impera</i>: boundaries shape the plant body and initiate new meristems
Wang, Q., Hasson, A., Rossmann, S., & Theres, K. (2016) · New Phytologist · doi:10.1111/nph.13641 · Cited by 106 · see citing works
- Authors
- Couzigou, J.-M., Zhukov, V., Mondy, S., Abu el Heba, G., Cosson, V., Ellis, T. H. N., Ambrose, M., Wen, J., Tadege, M., Tikhonovich, I., Mysore, K. S., Putterill, J., Hofer, J., Borisov, A. Y., & Ratet, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- All-Russian Research Institute of Agricultural Microbiology (RU)
- Institut des Sciences du Végétal, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette cedex, France
- Institute of Biological, Environmental, and Rural Sciences, Aberystwyth University, Aberystwyth SY23 3EB, United Kingdom
- John Innes Centre (GB)
- Noble Research Institute (US)
- Oklahoma State University (US)
- University of Auckland (NZ)
- Aberystwyth University (GB)
- ORCID
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-11
- Volume
- 24
- Issue
- 11
- Pages
- 4498-4510
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- PMC
- PMC3531848
- OpenAlex
- W2151618506
- Cited by
- 145
- References
- 1
- Citations by year
- 2026: 9 · 2025: 4 · 2024: 9 · 2023: 11 · 2022: 15 · 2021: 10 · 2020: 14 · 2019: 12 · 2018: 13 · 2017: 6 · 2016: 9 · 2015: 15 · 2014: 7 · 2013: 11
- FWCI
- 12.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- The Plant Cell (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- ResearchSpace (University of Auckland) (submittedVersion)
- Funders
- United Nations Educational, Scientific and Cultural Organization
- Russian Foundation for Basic Research
- Centre National de la Recherche Scientifique
- Académie d'agriculture de France
- Biotechnology and Biological Sciences Research Council (BBS/E/J/000CA493)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Legume Nitrogen Fixing Symbiosis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Parasitism and Resistance
- Keywords
- root nodules, nodulation, Medicago truncatula, Pisum sativum, legume-rhizobium symbiosis, nitrogen fixation, organ identity, orthologs
- MeSH terms
- Base Sequence, Molecular Sequence Data, Mutation, Nitrogen Fixation, Phenotype, Phylogeny, Plant Proteins, Recombinant Fusion Proteins, Symbiosis, Sinorhizobium meliloti, Arabidopsis, Sequence Analysis, DNA, Protein Structure, Tertiary, Gene Expression Regulation, Plant, Plant Leaves, Plant Roots, Pisum sativum, Flowers, Medicago truncatula, Root Nodules, Plant
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
