The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
A bHLH-Type Transcription Factor, ABA-INDUCIBLE BHLH-TYPE TRANSCRIPTION FACTOR/JA-ASSOCIATED MYC2-LIKE1, Acts as a Repressor to Negatively Regulate Jasmonate Signaling in Arabidopsis
Open accessAbstract
Jasmonates (JAs) are plant hormones that regulate the balance between plant growth and responses to biotic and abiotic stresses. Although recent studies have uncovered the mechanisms for JA-induced responses in Arabidopsis thaliana, the mechanisms by which plants attenuate the JA-induced responses remain elusive. Here, we report that a basic helix-loop-helix–type transcription factor, ABA-INDUCIBLE BHLH-TYPE TRANSCRIPTION FACTOR/JA-ASSOCIATED MYC2-LIKE1 (JAM1), acts as a transcriptional repressor and negatively regulates JA signaling. Gain-of-function transgenic plants expressing the chimeric repressor for JAM1 exhibited substantial reduction of JA responses, including JA-induced inhibition of root growth, accumulation of anthocyanin, and male fertility. These plants were also compromised in resistance to attack by the insect herbivore Spodoptera exigua. Conversely, jam1 loss-of-function mutants showed enhanced JA responsiveness, including increased resistance to insect attack. JAM1 and MYC2 competitively bind to the target sequence of MYC2, which likely provides the mechanism for negative regulation of JA signaling and suppression of MYC2 functions by JAM1. These results indicate that JAM1 negatively regulates JA signaling, thereby playing a pivotal role in fine-tuning of JA-mediated stress responses and plant growth.
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Cites
JAZ repressor proteins are targets of the SCFCOI1 complex during jasmonate signalling
Thines, B., Katsir, L., Melotto, M., Niu, Y., Mandaokar, A., Liu, G., Nomura, K., He, S. Y., Howe, G. A., & Browse, J. (2007) · Nature · doi:10.1038/nature05960 · Cited by 2,520
Self-citationThe JAZ family of repressors is the missing link in jasmonate signalling
Chini, A., Fonseca, S., Fernández, G., Adie, B., Chico, J. M., Lorenzo, O., García-Casado, G., López-Vidriero, I., Lozano, F. M., Ponce, M. R., et al. (2007) · Nature · doi:10.1038/nature06006 · Cited by 2,432
Wasternack, C. (2007) · Annals of Botany · doi:10.1093/aob/mcm079 · Cited by 1,835
COI1 : An Arabidopsis Gene Required for Jasmonate-Regulated Defense and Fertility
Xie, D.-X., Feys, B. F., James, S., Nieto-Rostro, M., & Turner, J. G. (1998) · Science · doi:10.1126/science.280.5366.1091 · Cited by 1,655
Jasmonate perception by inositol-phosphate-potentiated COI1–JAZ co-receptor
Sheard, L. B., Tan, X., Mao, H., Withers, J., Ben-Nissan, G., Hinds, T. R., Kobayashi, Y., Hsu, F.-F., Sharon, M., Browse, J., et al. (2010) · Nature · doi:10.1038/nature09430 · Cited by 1,497
Self-citationLorenzo, O., Piqueras, R., Sánchez-Serrano, J. J., & Solano, R. (2003) · The Plant Cell · doi:10.1105/tpc.007468 · Cited by 1,405
Lorenzo, O., Chico, J. M., Saénchez-Serrano, J. J., & Solano, R. (2004) · The Plant Cell · doi:10.1105/tpc.022319 · Cited by 1,344
Anderson, J. P., Badruzsaufari, E., Schenk, P. M., Manners, J. M., Desmond, O. J., Ehlert, C., Maclean, D. J., Ebert, P. R., & Kazan, K. (2004) · The Plant Cell · doi:10.1105/tpc.104.025833 · Cited by 1,209
Fernández-Calvo, P., Chini, A., Fernández-Barbero, G., Chico, J.-M., Gimenez-Ibanez, S., Geerinck, J., Eeckhout, D., Schweizer, F., Godoy, M., Franco-Zorrilla, J. M., et al. (2011) · The Plant Cell · doi:10.1105/tpc.110.080788 · Cited by 1,156
MYC2 Differentially Modulates Diverse Jasmonate-Dependent Functions in Arabidopsis
Dombrecht, B., Xue, G. P., Sprague, S. J., Kirkegaard, J. A., Ross, J. J., Reid, J. B., Fitt, G. P., Sewelam, N., Schenk, P. M., Manners, J. M., et al. (2007) · The Plant Cell · doi:10.1105/tpc.106.048017 · Cited by 1,127
Cited by
Diverse roles of jasmonates and ethylene in abiotic stress tolerance
Kazan, K. (2015) · Trends in Plant Science · doi:10.1016/j.tplants.2015.02.001 · Cited by 854
Jasmonate-responsive transcription factors regulating plant secondary metabolism
Zhou, M., & Memelink, J. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.02.004 · Cited by 378
Resolution of growth–defense conflict: mechanistic insights from jasmonate signaling
Guo, Q., Major, I. T., & Howe, G. A. (2018) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2018.02.009 · Cited by 292
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Metadata
- Authors
- Nakata, M., Mitsuda, N., Herde, M., Koo, A. J. K., Moreno, J. E., Suzuki, K., Howe, G. A., & Ohme-Takagi, M.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-05-01
- Volume
- 25
- Issue
- 5
- Pages
- 1641-1656
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2152487831
- Cited by
- 331
- References
- 74
- FWCI
- 26.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: A bHLH-Type Transcription Factor, ABA-INDUCIBLE BHLH-TYPE TRANSCRIPTION FACTOR/JA-ASSOCIATED MYC2-LIKE1, Acts as a Repressor to Negatively Regulate Jasmonate Signaling in Arabidopsis. https://app.cochat.ai/papers/10.1105/tpc.113.111112
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- Nakata, M., Mitsuda, N., Herde, M., Koo, A. J. K., Moreno, J. E., Suzuki, K., Howe, G. A., & Ohme-Takagi, M. (2013). A bHLH-Type Transcription Factor, ABA-INDUCIBLE BHLH-TYPE TRANSCRIPTION FACTOR/JA-ASSOCIATED MYC2-LIKE1, Acts as a Repressor to Negatively Regulate Jasmonate Signaling in Arabidopsis. The Plant Cell. https://doi.org/10.1105/tpc.113.111112
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