The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Light-Activated Phytochrome A and B Interact with Members of the SPA Family to Promote Photomorphogenesis in Arabidopsis by Reorganizing the COP1/SPA Complex
Open accessAbstract
Phytochromes function as red/far-red photoreceptors in plants and are essential for light-regulated growth and development. Photomorphogenesis, the developmental program in light, is the default program in seed plants. In dark-grown seedlings, photomorphogenic growth is suppressed by the action of the CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1)/SUPPRESSOR OF phyA-105 (SPA) complex, which targets positive regulators of photomorphogenic growth for degradation by the proteasome. Phytochromes inhibit the COP1/SPA complex, leading to the accumulation of transcription factors promoting photomorphogenesis; yet, the mechanism by which they inactivate COP1/SPA is still unknown. Here, we show that light-activated phytochrome A (phyA) and phytochrome B (phyB) interact with SPA1 and other SPA proteins. Fluorescence resonance energy transfer-fluorescence lifetime imaging microscopy analyses show that SPAs and phytochromes colocalize and interact in nuclear bodies. Furthermore, light-activated phyA and phyB disrupt the interaction between COP1 and SPAs, resulting in reorganization of the COP1/SPA complex in planta. The light-induced stabilization of HFR1, a photomorphogenic factor targeted for degradation by COP1/SPA, correlates temporally with the accumulation of phyA in the nucleus and localization of phyA to nuclear bodies. Overall, these data provide a molecular mechanism for the inactivation of the COP1/SPA complex by phyA- and phyB-mediated light perception.
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1 retracted
Voinnet, O., Rivas, S., Mestre, P., & Baulcombe, D. (2003) · The Plant Journal · doi:10.1046/j.1365-313x.2003.01676.x · Cited by 1,734
RetractedThe p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
Wade Harper, J. (1993) · Cell · doi:10.1016/0092-8674(93)90499-g · Cited by 5,651
Targeted destabilization of HY5 during light-regulated development of Arabidopsis
Osterlund, M. T., Hardtke, C. S., Wei, N., & Deng, X. W. (2000) · Nature · doi:10.1038/35013076 · Cited by 1,359
Perception of UV-B by the Arabidopsis UVR8 Protein
Rizzini, L., Favory, J.-J., Cloix, C., Faggionato, D., O’Hara, A., Kaiserli, E., Baumeister, R., Schäfer, E., Nagy, F., Jenkins, G. I., et al. (2011) · Science · doi:10.1126/science.1200660 · Cited by 1,134
PHYTOCHROME STRUCTURE AND SIGNALING MECHANISMS
Rockwell, N. C., Su, Y.-S., & Lagarias, J. C. (2006) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.56.032604.144208 · Cited by 1,088
Light-Regulated Plant Growth and Development
Kami, C., Lorrain, S., Hornitschek, P., & Fankhauser, C. (2010) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)91002-8 · Cited by 927
Phytochrome functions in Arabidopsis development
Franklin, K. A., & Quail, P. H. (2010) · Journal of Experimental Botany · doi:10.1093/jxb/erp304 · Cited by 848
Ni, M., Tepperman, J. M., & Quail, P. H. (1998) · Cell · doi:10.1016/s0092-8674(00)81636-0 · Cited by 733
Phytochrome A and Phytochrome B Have Overlapping but Distinct Functions in Arabidopsis Development
Reed, J. W., Nagatani, A., Elich, T. D., Fagan, M., & Chory, J. (1994) · Plant Physiology · doi:10.1104/pp.104.4.1139 · Cited by 672
Ang, L.-H., Chattopadhyay, S., Wei, N., Oyama, T., Okada, K., Batschauer, A., & Deng, X.-W. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80022-2 · Cited by 669
Cited by
Molecular mechanisms underlying phytochrome-controlled morphogenesis in plants
Legris, M., Ince, Y. Ç., & Fankhauser, C. (2019) · Nature Communications · doi:10.1038/s41467-019-13045-0 · Cited by 429
Plant photoreceptors: Multi-functional sensory proteins and their signaling networks
Paik, I., & Huq, E. (2019) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2019.03.007 · Cited by 373
Self-citationCircadian Clock and Photoperiodic Flowering in Arabidopsis: CONSTANS Is a Hub for Signal Integration
Shim, J. S., Kubota, A., & Imaizumi, T. (2017) · Plant Physiology · doi:10.1104/pp.16.01327 · Cited by 359
Phytochrome Signaling Networks
Cheng, M.-C., Kathare, P. K., Paik, I., & Huq, E. (2021) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-080620-024221 · Cited by 313
Self-citationPhotoreceptor-mediated regulation of the COP1/SPA E3 ubiquitin ligase
Podolec, R., & Ulm, R. (2018) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2018.04.018 · Cited by 292
Metadata
- Authors
- Sheerin, D. J., Menon, C., zur Oven-Krockhaus, S., Enderle, B., Zhu, L., Johnen, P., Schleifenbaum, F., Stierhof, Y.-D., Huq, E., & Hiltbrunner, A.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-01
- Volume
- 27
- Issue
- 1
- Pages
- 189-201
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2152793376
- Cited by
- 351
- References
- 45
- FWCI
- 37.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Sheerin, D. J., Menon, C., zur Oven-Krockhaus, S., Enderle, B., Zhu, L., Johnen, P., Schleifenbaum, F., Stierhof, Y.-D., Huq, E., & Hiltbrunner, A. (2015). Light-Activated Phytochrome A and B Interact with Members of the SPA Family to Promote Photomorphogenesis in Arabidopsis by Reorganizing the COP1/SPA Complex. The Plant Cell. https://doi.org/10.1105/tpc.114.134775
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