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Suppression of Virus Accumulation in Transgenic Plants Exhibiting Silencing of Nuclear Genes.
Open accessAbstract
Homology-dependent gene silencing contributes to variation between transgenic plants with respect to transgene and/or endogenous gene expression levels. Recent studies have linked post-transcriptional gene silencing and virus resistance in plants expressing virus-derived transgenes. Using a potato virus X vector, we present three examples in which silencing of nonviral transgenes prevented virus accumulation. This effect was dependent on sequence homology between the virus and the silenced transgene. Analysis of potato virus X derivatives carrying bacterial [beta]-glucuronidase (GUS) sequences showed that the 3[prime] region of the GUS coding sequence was a target of the silencing mechanism in two independent tobacco lines. Methylation of the silenced GUS transgenes in these lines was also concentrated in the 3[prime] region of the GUS coding sequence. Based on this concurrence, we propose a link between the DNA-based transgene methylation and the RNA-based gene silencing process.
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Cited by
Two classes of short interfering RNA in RNA silencing
Hamilton, A., Voinnet, O., Chappell, L., & Baulcombe, D. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf464 · Cited by 809
Self-citationRNA as a target and an initiator of post-transcriptional gene silencing in trangenic plants
Baulcombe, D. C. (1996) · Plant Molecular Biology · doi:10.1007/bf00039378 · Cited by 285
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Metadata
- Authors
- English, J. J., Mueller, E., & Baulcombe, D. C.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-02-01
- Volume
- 8
- Issue
- 2
- Pages
- 179-188
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2079017128
- Cited by
- 371
- References
- 0
- FWCI
- 58.21
- Type
- journal article
- Language
- en
- Open access
- green
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- English, J. J., Mueller, E., & Baulcombe, D. C. (1996). Suppression of Virus Accumulation in Transgenic Plants Exhibiting Silencing of Nuclear Genes. The Plant Cell. https://doi.org/10.1105/tpc.8.2.179
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