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Hexokinase as a sugar sensor in higher plants.
Open accessAbstract
The mechanisms by which higher plants recognize and respond to sugars are largely unknown. Here, we present evidence that the first enzyme in the hexose assimilation pathway, hexokinase (HXK), acts as a sensor for plant sugar responses. Transgenic Arabidopsis plants expressing antisense hexokinase (AtHXK) genes are sugar hyposensitive, whereas plants overexpressing AtHXK are sugar hypersensitive. The transgenic plants exhibited a wide spectrum of altered sugar responses in seedling development and in gene activation and repression. Furthermore, overexpressing the yeast sugar sensor YHXK2 caused a dominant negative effect by elevating HXK catalytic activity but reducing sugar sensitivity in transgenic plants. The result suggests that HXK is a dual-function enzyme with a distinct regulatory function not interchangeable between plants and yeast.
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Citations
Cited by
SUGAR SENSING AND SIGNALING IN PLANTS: Conserved and Novel Mechanisms
Rolland, F., Baena-Gonzalez, E., & Sheen, J. (2006) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.57.032905.105441 · Cited by 2,328
Self-citationRISING ATMOSPHERIC CARBON DIOXIDE: Plants FACE the Future
Long, S. P., Ainsworth, E. A., Rogers, A., & Ort, D. R. (2004) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.55.031903.141610 · Cited by 1,715
STITT, M., & KRAPP, A. (1999) · Plant, Cell & Environment · doi:10.1046/j.1365-3040.1999.00386.x · Cited by 1,044
The biochemical and molecular basis for photosynthetic acclimation to elevated atmospheric CO2
MOORE, B. D., CHENG, S. ‐., SIMS, D., & SEEMANN, J. R. (1999) · Plant, Cell & Environment · doi:10.1046/j.1365-3040.1999.00432.x · Cited by 458
Reed, R. C., Brady, S. R., & Muday, G. K. (1998) · Plant Physiology · doi:10.1104/pp.118.4.1369 · Cited by 448
Metadata
- Authors
- Jang, J. C., León, P., Zhou, L., & Sheen, J.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-01
- Volume
- 9
- Issue
- 1
- Pages
- 5-19
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2086968057
- Cited by
- 897
- References
- 0
- FWCI
- 82.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jang, J. C., León, P., Zhou, L., & Sheen, J. (1997). Hexokinase as a sugar sensor in higher plants. The Plant Cell. https://doi.org/10.1105/tpc.9.1.5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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