Neurobiological evaluation of thin-film longitudinal intrafascicular electrodes as a peripheral nerve interface,
Abstract
Longitudinal intrafascicular electrodes (LIFEs) designed to be placed inside a peripheral nerve seem adequate devices for constituting a nerve-prosthesis interface. In this study we evaluated the functional and morphological effects of newly designed polyimide-based thin-film (tf-)LIFEs implanted in the rat sciatic nerve for 3 months. The tf-LIFEs used are highly flexible, and have 8 regularly spaced contacts, 4 at each side of the folded structure. Functional results at 1 month showed a mild decline in nerve conduction velocity and amplitude of muscle responses, which recovered during the following 2 months. Histological results showed a mild scar response around the intraneural electrode, but no signs of axonal loss and degeneration. Longitudinally implanted LIFEs behaved slightly better than transversally inserted LIFEs. Acute experiments proved that selective neural signal recording and nerve stimulation could be achieved from the different active sites in one tf-LIFE.
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tfLIFEs functional decline due to surgical implantation and mechanical damage was slight and reversible after 3 months.
“Navarro et al. showed that tfLIFEs functional decline due to surgical implantation and mechanical damage was slight and reversible after 3 months.”
From Update on Peripheral Nerve Electrodes for Closed-Loop Neuroprosthetics (2018) · cites this paper as Navarro et al., 2007
Histological evaluation in a rat model after several months showed a mild inflammatory reaction and no evidence of nerve degeneration for tfLIFEs.
“Moreover, histological evaluation in a rat model after several months showed a mild inflammatory reaction and no evidence of nerve degeneration (Navarro et al., 2007).”
From Update on Peripheral Nerve Electrodes for Closed-Loop Neuroprosthetics (2018) · cites this paper as Navarro et al., 2007
Spatial resolution decreases after implantation because an inflammatory tissue response damages nerve cells and creates an insulating layer between the nerve and the electrode.
“Lastly, the spatial resolution decreases after implantation because of an inflammatory tissue response around the electrode, which can damage the nerve cells and create an insulating layer between the nerve and the electrode (Navarro et al., 2007; Christensen et al., 2014; Kundu et al., 2014b).”
From Update on Peripheral Nerve Electrodes for Closed-Loop Neuroprosthetics (2018) · cites this paper as Navarro et al., 2007
Longitudinally implanted thin-film longitudinal intra-fascicular electrodes showed less functional decline compared to transversally implanted ones during in vivo testing.
“Although, longitudinally implanted tf-LIFEs showed less functional decline compared to transversally implanted ones during in vivo testing [90].”
From Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review (2020) · cites this paper as [90]
In a rat study, thin-film longitudinal intra-fascicular electrodes caused a mild functional decline during the first month attributable to nerve damage during implantation, but rats recovered after the following two months without any sign of nerve degeneration.
“In a rat study, it caused a mild functional decline during the first month, attributable to nerve damage during implantation. Nonetheless the rats recovered after the following two months without any sign of nerve degeneration [90].”
From Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review (2020) · cites this paper as [90]
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References 25 · Cited by 36
- Authors
- Navarro, X., Lago, N., Vivo, M., Yoshida, K., Koch, K. P., Poppendieck, W., & Micera, S.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Institute of Neurosciences, Universitat Autònoma de Barcelona, Bellaterra, Spain. e-mail: meritxell.vivo@uab.cat
- Aalborg University (DK)
- Fraunhofer Institute for Biomedical Engineering (DE)
- Scuola Superiore Sant'Anna (IT)
- Venue
- 2007 IEEE 10th International Conference on Rehabilitation Robotics
- Publisher
- IEEE
- Published
- 2007-06
- Pages
- 643-649
- ISSN
- 1945-7898 (ISSN-L)
- OpenAlex
- W2137910464
- Cited by
- 36
- References
- 25
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 5
- FWCI
- 2.27
- Type
- conference paper
- Language
- en
- Open access
- closed
- Locations
- International Conference on Rehabilitation Robotics (publishedVersion)
- Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft) (submittedVersion)
- Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
- VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Keywords
- thin film electrodes, peripheral nerve interfaces, polyimide electrodes, sciatic nerve, nerve conduction velocity, muscle response, scar formation, axonal loss, neural recording, neurostimulation, flexible electrodes, rat model
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