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Optical sensing of biomolecules using microring resonators
Abstract
A biosensor application of vertically coupled glass microring resonators with Q/spl sim/12 000 is introduced. Using balanced photodetection, very high signal to noise ratios, and thus high sensitivity to refractive index changes (limit of detection of 1.8/spl times/10/sup -5/ refractive index units), are achieved. Ellipsometry and X-ray photoelectron spectroscopy results indicate successful modification of biosensor surfaces. Experimental data obtained separately for a bulk change of refractive index of the medium and for avidin-biotin binding on the ring surface are reported. Excellent repeatability and close-to-complete surface regeneration after binding are experimentally demonstrated.
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Citations
Cites
Vahala, K. J. (2003) · Nature · doi:10.1038/nature01939 · Cited by 4,878
Cited by
Iqbal, M., Gleeson, M. A., Spaugh, B., Tybor, F., Gunn, W. G., Hochberg, M., Baehr-Jones, T., Bailey, R. C., & Gunn, L. C. (2010) · IEEE Journal of Selected Topics in Quantum Electronics · doi:10.1109/jstqe.2009.2032510 · Cited by 551
Advances and Prospects for Whispering Gallery Mode Microcavities
Yang, S., Wang, Y., & Sun, H. (2015) · Advanced Optical Materials · doi:10.1002/adom.201500232 · Cited by 395
Optical ring resonators for biochemical and chemical sensing
Sun, Y., & Fan, X. (2011) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-4237-z · Cited by 355
Detection of Single Nanoparticles and Lentiviruses Using Microcavity Resonance Broadening
Shao, L., Jiang, X., Yu, X., Li, B., Clements, W. R., Vollmer, F., Wang, W., Xiao, Y., & Gong, Q. (2013) · Advanced Materials · doi:10.1002/adma201302572 · Cited by 317
High-Q Optical Sensors for Chemical and Biological Analysis
Luchansky, M. S., & Bailey, R. C. (2012) · Analytical Chemistry · doi:10.1021/ac2029024 · Cited by 288
Metadata
- Authors
- Yalcin, A., Popat, K. C., Aldridge, J. C., Desai, T. A., Hryniewicz, J., Chbouki, N., Little, B. E., King, O., Van, V., Chu, S., Gill, D., Anthes-Washburn, M., Unlu, M. S., & Goldberg, B. B.
- Venue
- IEEE Journal of Selected Topics in Quantum Electronics
- Published
- 2006-01
- Volume
- 12
- Issue
- 1
- Pages
- 148-155
- ISSN
- 1077-260X (ISSN-L)
- OpenAlex
- W2128764859
- Cited by
- 377
- References
- 1
- FWCI
- 33.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Yalcin, A., Popat, K. C., Aldridge, J. C., Desai, T. A., Hryniewicz, J., Chbouki, N., Little, B. E., King, O., Van, V., Chu, S., Gill, D., Anthes-Washburn, M., Unlu, M. S., & Goldberg, B. B. (2006). Optical sensing of biomolecules using microring resonators. IEEE Journal of Selected Topics in Quantum Electronics. https://doi.org/10.1109/jstqe.2005.863003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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