DNA-Based Storage: Trends and Methods
Open accessAbstract
We provide an overview of current approaches to DNA-based storage system design and of accompanying synthesis, sequencing and editing methods. We also introduce and analyze a suite of new constrained coding schemes for both archival and random access DNA storage channels. The analytic contribution of our work is the construction and design of sequences over discrete alphabets that avoid pre-specified address patterns, have balanced base content, and exhibit other relevant substring constraints. These schemes adapt the stored signals to the DNA medium and thereby reduce the inherent error-rate of the system.
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Next-generation sequencing methods enable reading individual molecules and thus using DNA as a source of random number generation.
“Nowadays, next-generation sequencing methods offer remarkable throughput18–20 and enable us to read individual molecules and thus use DNA as a source of random number generation.”
From DNA synthesis for true random number generation (2020) · cites this paper as [18]
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References 87 · Cited by 278
Research works printed but not linked: 3
- S. C. Schuster, "Next-generation sequencing transforms today's biology," Nature methods, vol. 5, no. 1, pp. 16-18, 2008.
- V. Levenshtein, "Decoding automata, invariant with respect to the initial state," Problemy Kibernet, vol. 12, pp. 125-136, 1964.
- R. Varshamov and G. Tenenholtz, "A code for correcting a single asymmetric error," Automatica i Telemekhanika, vol. 26, no. 2, pp. 288- 292, 1965.
- Authors
- Yazdi, S. M. H. T., Kiah, H. M., Garcia-Ruiz, E., Ma, J., Zhao, H., & Milenkovic, O.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- Nanyang Technological University (SG)
- Venue
- IEEE Transactions on Molecular, Biological and Multi-Scale Communications
- Published
- 2015-09
- Volume
- 1
- Issue
- 3
- Pages
- 230-248
- ISSN
- 2332-7804 (ISSN-L)
- 2372-2061
- OpenAlex
- W1682729512
- Cited by
- 278
- References
- 87
- Citations by year
- 2026: 33 · 2025: 30 · 2024: 37 · 2023: 28 · 2022: 28 · 2021: 31 · 2020: 30 · 2019: 19 · 2018: 20 · 2017: 14 · 2016: 7 · 2015: 1
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- green
- arxiv.org
- Locations
- IEEE Transactions on Molecular Biological and Multi-Scale Communications (publishedVersion)
- arXiv (Cornell University) (submittedVersion)
- arXiv (Cornell University)
- Funders
- NSF STC Class 2010 CCF (0939370)
- Strategic Research Initiative (SRI)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Biological Computing
- Physical Sciences › Computer Science › Artificial Intelligence › Algorithms and Data Compression
- Physical Sciences › Engineering › Biomedical Engineering › Molecular Communication and Nanonetworks
- Keywords
- DNA data storage, constrained coding, DNA synthesis, DNA sequencing, DNA editing, archival storage, error rate reduction
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