Magnetic particle imaging with tailored iron oxide nanoparticle tracers
Open accessAbstract
Magnetic particle imaging (MPI) shows promise for medical imaging, particularly in angiography of patients with chronic kidney disease. As the first biomedical imaging technique that truly depends on nanoscale materials properties, MPI requires highly optimized magnetic nanoparticle tracers to generate quality images. Until now, researchers have relied on tracers optimized for MRI T2(∗) -weighted imaging that are sub-optimal for MPI. Here, we describe new tracers tailored to MPI's unique physics, synthesized using an organic-phase process and functionalized to ensure biocompatibility and adequate in vivo circulation time. Tailored tracers showed up to 3 × greater signal-to-noise ratio and better spatial resolution than existing commercial tracers in MPI images of phantoms.
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Upon surface modification, superparamagnetic iron oxide nanoparticles (SPION) can be employed for magnetic resonance imaging, magnetic particle imaging, targeted delivery of drugs, proteins, antibodies and nucleic acids, hyperthermia, biosensing, tissue repair, and separation of biomolecules.
“Upon surface-modification, the resulting superparamagnetic iron oxide nanoparticles (SPION) can be employed for magnetic resonance imaging (MRI) [4–8], magnetic particle imaging (MPI) [9–12], targeted delivery of drugs, proteins, antibodies, and nucleic acids [6, 7, 13, 14], hyperthermia [15–17], biosensing [18], tissue repair [19], and separation of biomolecules [20].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [11]
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References 43 · Cited by 222
Research works printed but not linked: 3
- [8]USRDS Annual Data Report Vol. 1: Atlas of Chronic Kidney Disease in the United States 9 2012
- [33]Gleich B Weizenecker J Timminger H Bontus C Schmale I Rahmer J Schmidt J Kanzenbach J Borgert J Fast MPI Demonstrator with Enlarged Field of View Proceedings of ISMRM 11 2010 18 218
- [34]Rahmer J Gleich B Bontus C Schmale I Schmidt J Kanzenbach J Woywode O Weizenecker J Borgert J Rapid 3D in vivo Magnetic Particle Imaging with a large field of view Proceedings of ISMRM 11 2011 19 269
- Authors
- Ferguson, R. M., Khandhar, A. P., Kemp, S. J., Arami, H., Saritas, E. U., Croft, L. R., Konkle, J., Goodwill, P. W., Halkola, A., Rahmer, J., Borgert, J., Conolly, S. M., & Krishnan, K. M.
- Affiliations
- LodeSpin Labs (United States) (US)
- University of Washington (US)
- University of California, Berkeley (US)
- University of Lübeck (DE)
- Corresponding author
- Krishnan, Kannan M.
- ORCID
- Venue
- IEEE Transactions on Medical Imaging
- Published
- 2015-05
- Volume
- 34
- Issue
- 5
- Pages
- 1077-1084
- ISSN
- 0278-0062 (ISSN-L)
- 1558-254X
- PMC
- PMC4428902
- OpenAlex
- W2088656686
- Cited by
- 222
- References
- 43
- Citations by year
- 2026: 12 · 2025: 14 · 2024: 13 · 2023: 12 · 2022: 17 · 2021: 14 · 2020: 27 · 2019: 25 · 2018: 22 · 2017: 34 · 2016: 17 · 2015: 13 · 2014: 2
- FWCI
- 11.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- IEEE Transactions on Medical Imaging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation (IIP-1215556)
- National Institutes of Health (1R01EB013689-01/NIBIB, 2R42EB013520-02A1)
- German Federal Ministry of Education and Research (13N11086, 13N9079)
- California Institute for Regenerative Medicine (RT2-01893)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
- Keywords
- magnetic particle imaging, iron oxide nanoparticles, nanoparticle tracers, biocompatibility, angiography, chronic kidney disease, signal-to-noise ratio, spatial resolution, phantoms
- MeSH terms
- Contrast Media, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Phantoms, Imaging, Magnetite Nanoparticles
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