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MPtopo: A database of membrane protein topology
Open accessAbstract
The reliability of the transmembrane (TM) sequence assignments for membrane proteins (MPs) in standard sequence databases is uncertain because the vast majority are based on hydropathy plots. A database of MPs with dependable assignments is necessary for developing new computational tools for the prediction of MP structure. We have therefore created MPtopo, a database of MPs whose topologies have been verified experimentally by means of crystallography, gene fusion, and other methods. Tests using MPtopo strongly validated four existing MP topology‐prediction algorithms. MPtopo is freely available over the internet and can be queried by means of an SQL‐based search engine.
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Cites
Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor
Palczewski, K., Kumasaka, T., Hori, T., Behnke, C. A., Motoshima, H., Fox, B. A., Trong, I. L., Teller, D. C., Okada, T., Stenkamp, R. E., et al. (2000) · Science · doi:10.1126/science.289.5480.739 · Cited by 5,637
Metadata
- Authors
- Jayasinghe, S., Hristova, K., & White, S. H.
- Venue
- Protein Science
- Publisher
- Wiley
- Published
- 2001-02
- Volume
- 10
- Issue
- 2
- Pages
- 455-458
- ISSN
- 0961-8368 (ISSN-L)
- 1469-896X
- OpenAlex
- W2074266029
- Cited by
- 166
- References
- 1
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jayasinghe, S., Hristova, K., & White, S. H. (2001). MPtopo: A database of membrane protein topology. Protein Science. https://doi.org/10.1110/ps.43501
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