Cited by 48Statistical Methods in EpidemiologyMeta-analysis and systematic reviewsAdvanced Causal Inference Techniques

Requiem for odds ratios

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Norton, Edward C., Dowd, Bryan E., Garrido, Melissa M., Maciejewski, Matthew L.·2024·Health Services Research

Abstract

Health Services Research encourages authors to report marginal effects instead of odds ratios for logistic regression with a binary outcome.Specifically, in the instructions for authors, Manuscript Formatting and Submission Requirements, section 2.4.2.2 Structured abstract and keywords, it reads "Reporting of odds ratios is discouraged (marginal effects preferred) except in case-control studies" (see the HSR website https:// www.hsr.org/

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  • Calculation of odds ratios incorporates unobserved study and modeling error into the denominator, making odds ratios relatively ungeneralizable.

    “Calculation of odds ratios incorporates unobserved study and modeling error into the denominator of the calculation, making odds ratios relatively ungeneralizable (Norton et al., 2024).”

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Research works printed but not linked: 8

  1. [1]Sackett DL, Deeks JJ, Altman DG. Down with odds ratios! Evidence Based Med. 1996; 1(6): 164‐ 166.
  2. [2]Tajeu GS, Sen B, Allison DB, Menachemi N. Misuse of odds ratios in obesity literature: an empirical analysis of published studies. Obesity. 2012; 20(8): 1726‐ 1731. 22436842 PMC3399983
  3. [3]Norton EC, Dowd BE. Log odds and the interpretation of logit models. Health Serv Res. 2018; 53(2): 859‐ 878. 28560732 PMC5867187
  4. [4]Norton EC, Dowd BE, Maciejewski ML. Odds ratios—current best practice and use. JAMA. 2018; 320(1): 84‐ 85. 29971384
  5. [5]Mroz TA, Zayats YV. Arbitrarily normalized coefficients, Information sets, and false reports of “biases” in binary outcome models. Rev Econ Stat. 2008; 90(3): 406‐ 413.
  6. [6]Allison PD. Comparing logit and probit coefficients across groups. Soc Methods Res. 1999; 28(2): 186‐ 208.
  7. [7]Mood C. Logistic regression: why we cannot do what we think we can do, and what we can do about it. Europ Soc Rev. 2010; 26(1): 67‐ 82.
  8. [8]Norton EC, Dowd BE, Maciejewski ML. Marginal effects—quantifying the effect of changes in risk factors in logistic regression models. JAMA. 2019; 321(13): 1304‐ 1305. 30848814

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Authors
Norton, E. C., Dowd, B. E., Garrido, M. M., & Maciejewski, M. L.
Affiliations
  • University of Michigan (US)
  • University of Minnesota (US)
  • Boston University (US)
  • Duke University (US)
Corresponding author
Norton, Edward C.
Venue
Health Services Research
Publisher
Wiley
Published
2024-06
Volume
59
Issue
4
Pages
e14337-e14337
ISSN
  • 0017-9124 (ISSN-L)
  • 1475-6773
OpenAlex
W4399260819
Cited by
48
References
0
Citations by year
2026: 17 · 2025: 25 · 2024: 6
FWCI
16.54
Type
journal article
Language
en
Open access
Locations
  • Health Services Research (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Deep Blue (University of Michigan) (submittedVersion)
Funders
U.S. Department of Veterans Affairs (RCS 10‐391)
Topics
  • Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
  • Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
  • Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
Keywords
odds ratio, marginal effects, logistic regression, binary outcomes, reporting guidelines, case-control study, effect size interpretation

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