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The In Vitro Permeability Of Skin And Buccal Mucosa To Selected Drugs And Tritiated Water
Open accessAbstract
The permeability of whole human skin, human dermis, whole pig skin, and canine buccal mucosa have been determined for four chemically different solutes: tritiated water, amphetamine, estradiol, and ouabain. Several new in vitro techniques for isolation, preservation, and permeability determination of these membranous tissues are described. Water permeabilities of human epidermis and dermis using these techniques agree well with published results. Human and porcine skins are very similar with respect to water permeability, while buccal mucosa is similar to dermis in its permeability characteristics to the four representative test agents. The permeability of hydrated whole skin is determined by the permeability of the epidermis, and the dermis and buccal mucosa behave as if they are water barriers exhibiting a permeability of about 30% of the diffusion through pure water, a difference that can be ascribed to the porosity and/or tortuosity of the tissue matrix.
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Citations
Cited by
Drug Delivery via the Mucous Membranes of the Oral Cavity
Harris, D., & Robinson, J. R. (1992) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600810102 · Cited by 558
Thin films as an emerging platform for drug delivery
Karki, S., Kim, H., Na, S.-J., Shin, D., Jo, K., & Lee, J. (2016) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2016.05.004 · Cited by 543
New developments and opportunities in oral mucosal drug delivery for local and systemic disease
Hearnden, V., Sankar, V., Hull, K., Juras, D. V., Greenberg, M., Kerr, A. R., Lockhart, P. B., Patton, L. L., Porter, S., & Thornhill, M. H. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.02.008 · Cited by 406
Pig and guinea pig skin as surrogates for human in vitro penetration studies: A quantitative review
Barbero, A. M., & Frasch, H. F. (2009) · Toxicology in Vitro · doi:10.1016/j.tiv.2008.10.008 · Cited by 351
Johnson, M. E., Blankschtein, D., & Langer, R. (1997) · Journal of Pharmaceutical Sciences · doi:10.1021/js960198e · Cited by 310
Metadata
- Authors
- Galey, W. R., Lonsdale, H. K., & Nacht, S.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 1976-12
- Volume
- 67
- Issue
- 6
- Pages
- 713-717
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2036433758
- Cited by
- 216
- References
- 0
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The In Vitro Permeability Of Skin And Buccal Mucosa To Selected Drugs And Tritiated Water. https://app.cochat.ai/papers/10.1111/1523-1747.ep12598596
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- Galey, W. R., Lonsdale, H. K., & Nacht, S. (1976). The In Vitro Permeability Of Skin And Buccal Mucosa To Selected Drugs And Tritiated Water. Journal of Investigative Dermatology. https://doi.org/10.1111/1523-1747.ep12598596
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
