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Cited by 20Optimism, Hope, and Well-beingDiabetes, Cardiovascular Risks, and LipoproteinsCardiac Health and Mental Health

Optimism, pessimism, cynical hostility, and biomarkers of metabolic function in the Women's Health Initiative: 妇女健康倡议研究中的乐观情绪、悲观情绪、愤世嫉俗型敌意与代谢功能生物标志物

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Tindle, Hilary A., Duncan, Meredith S., Liu, Simin, Kuller, Lewis H., Fugate Woods, Nancy, Rapp, Steve R., Kroenke, Candyce H., Coday, Mace +7 more·2018·Journal of Diabetes
DOI 10.1111/1753-0407.12584PMC PMC8835287
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Abstract

Background: Psychological attitudes reflecting expectations about the future (optimism, pessimism) and people (cynical hostility) independently predict incident cardiovascular disease and possibly diabetes, but underlying biologic pathways are incompletely understood. Herein we examined the cross‐sectional relationship between optimism, pessimism, and cynicism and biomarkers of metabolic function in the Women's Health Initiative. Methods: Among 3443 postmenopausal women, biomarkers of metabolic function (fasting insulin [FINS] and glucose) were measured at baseline and used to calculate insulin resistance (homeostasis model assessment of insulin resistance [HOMA‐IR]) and pancreatic β‐cell activity (homeostasis model assessment of β‐cell function [HOMA‐B]). Psychological attitudes were assessed by the Life Orientation Test, Revised (full scale, and optimism and pessimism subscales) and the Cook–Medley cynicism subscale. Multivariable linear regression modeled the association of psychological attitudes with biomarker levels, adjusting for sociodemographics, health conditions, and health behaviors. Because obesity promotes insulin resistance and obese individuals tend to report higher levels of pessimism and cynical hostility, an interaction with body mass index (BMI) was explored. Results: In fully adjusted models, only pessimism remained independently associated with higher FINS and insulin resistance (HOMA‐IR). Scoring 1 point higher on the pessimism subscale was associated with a 1.2% higher FINS, whereas scoring 1 SD higher was associated with a 2.7% higher FINS (P = 0.03); results were similar for HOMA‐IR. An interaction term with BMI was not significant. Conclusions: In multivariable models, higher dispositional pessimism was associated with worse metabolic function; these findings were not modified by obesity status. Results extend prior work by linking pessimism to an objective biomarker of insulin resistance in elderly women.

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  • Chronic distress is associated with detrimental processes, including hypercoagulability, dyslipidemia, impaired glucose control, and increased inflammatory processes and impaired immune responses.

    “Specifically, chronic distress is associated with detrimental processes, including hypercoagulability, dyslipidemia, 112-114 impaired glucose control, 115,116 and increased inflammatory processes and impaired immune responses. 95,117,118”

    From Psychological Health, Well-Being, and the Mind-Heart-Body Connection: A Scientific Statement From the American Heart Association (2021) · cites this paper as [116]

    The citation placement ties this paper to the impaired-glucose-control part of the sentence. In the Discussion (page unavailable), the paper suggests that chronic stress could disrupt insulin regulation, but explicitly calls that explanation speculative; its adjusted findings concern pessimism and insulin resistance, not a demonstrated association between chronic distress and impaired glucose control. (LLM, conf=0.86)

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Authors
Tindle, H. A., Duncan, M. S., Liu, S., Kuller, L. H., Fugate Woods, N., Rapp, S. R., Kroenke, C. H., Coday, M., Loucks, E. B., Lamonte, M. J., Progovac, A. M., Salmoirago‐Blotcher, E., Walitt, B. T., Yuo, N. Y., & Freiberg, M. S.
Affiliations
  • Vanderbilt University Medical Center (US)
  • Brown University (US)
  • University of Pittsburgh (US)
  • University of Washington, School of Nursing Seattle,Washington USA
  • Wake Forest Baptist Medical Center, Medical Center Boulevard Winston‐Salem North Carolina USA
  • Kaiser Permanente (US)
  • University of Tennessee Health Science Center (US)
  • University at Buffalo, State University of New York (US)
  • Harvard University (US)
  • National Institutes of Health (US)
  • University of California, Los Angeles (US)
Corresponding author
Tindle, Hilary A.
ORCID
Venue
Journal of Diabetes
Publisher
Wiley
Published
2017-09-29
Volume
10
Issue
6
Pages
512-523
ISSN
  • 1753-0393 (ISSN-L)
  • 1753-0407
DOI
10.1111/1753-0407.12584
PMC
PMC8835287
OpenAlex
W2735699940
Cited by
20
References
85
Citations by year
2023: 2 · 2022: 5 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 1
FWCI
2.50
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Diabetes (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Institute of Mental Health (T32MH019733)
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (HHSN268201100001C)
Topics
  • Social Sciences › Psychology › Applied Psychology › Optimism, Hope, and Well-being
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords
pessimism, optimism, cynical hostility, insulin resistance, fasting insulin, beta-cell function, metabolic biomarkers, postmenopausal women, body mass index, Life Orientation Test, psychological attitudes, cardiovascular risk
MeSH terms
Optimism, Pessimism, Aged, Cross-Sectional Studies, Female, Follow-Up Studies, Hostility, Humans, Insulin Resistance, Metabolic Diseases, Middle Aged, Prognosis, Risk Factors, United States, Biomarkers, Health Behavior, Women's Health

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