Characterization of age‐associated exhausted CD 8+ T cells defined by increased expression of Tim‐3 and PD‐1

Lee, Kyoo‐A, Shin, Kwang‐Soo, Kim, Ga‐Young, Song, You Chan, Bae, Eun‐Ah, Kim, Il‐Kyu, Koh, Choong‐Hyun, Kang, Chang‐Yuil·2016·Aging Cell
DOI 10.1111/acel.12435

Cited by (125)

Items 101–125 of 125

  1. Age-related modifications of macrophages influenced by “inflammageing” in graft vs. host disease
    Yaqun Hong, Bo Wan, Xiaofan Li · 2020 · Biocell
  2. Modelling Immune Dynamics in Locally Advanced MSI-H/dMMR Colorectal Cancer with Neoadjuvant Pembrolizumab Treatment: From Differential Equations to an Agent-Based Framework
    Georgio Hawi, Peter Kim, Peter P. Lee · 2026 · Bulletin of Mathematical Biology
  3. The immunological fitness of NSCLC patients drives the response to anti-PD1-based immunotherapy regardless of age
    Lucrezia Tuosto, Alain Jonathan Gelibter, Lidia Strigari, Angela Asquino, Marco Siringo, Angelica Pace, Flavio Valentino, Davide Capozzi, Serena Bianchini, Filippo Bellati et al. · 2026 · Journal of Translational Medicine
  4. Implication of T Cell Exhaustion in Neuropsychiatric Disorders: Neuroimmunopathology and Treatment Strategies
    Kiarash Saleki, Nima Rezaei · 2024 · Integrated science
  5. Aging Interacts with Tumor Biology to Produce Major Changes in the Immune Tumor Microenvironment
    Rossin Erbe, Zheyu Wang, Neeha Zaidi, Michael J. Topper, Stephen B. Baylin, Elizabeth M. Jaffee, Hariharan Easwaran, Elana Judith Fertig · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  6. CD8 + T-cell transcription and DNA methylation show age specific differences and lack correlation with clinical outcome in pediatric Inflammatory Bowel Disease
    Marco Gasparetto, Felicity Payne, Komal Nayak, Judith Kraiczy, Claire Glemas, Yosef Philip-McKenzie, Alexander Ross, Rachel D. Edgar, Daniel R. Zerbino, Camilla Salvestrini et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  7. AGING WITH T CELLS
    Pieren, Daniël Kees Johan · 2021
  8. Experimental Study of Yifeixiaoliu Granulesto Delays Immunosenescence and Prevents Senile Lung Cancer
    冬梅 魏 · 2023 · World Journal of Cancer Research
  9. The T cell senescence in breast cancer
    Sikrit Denariyakoon · 2022
  10. Low levels of peripheral blood activated and senescent T cells characterize people with HIV-1-associated neurocognitive disorders
    Lucy Kundura, Renaud Cezar, Manuela Pastore, Christelle Reynès, Jérémy Deverdun, Emmanuelle Le Bars, Albert Sotto, Jacques Reynes, Alain Makinson, Pierre Corbeau · 2023 · Frontiers in Immunology
  11. The Role of NAD+-Dependent Signal Mechanisms in Cancer Development and Treatment
    Ting Lu, Zheng‐Hong Qin, Junchao Wu · 2025 · Springer eBooks
  12. Fibroblast orchestration of inflammaging via NF-kB activation
    Nancy C. Allen, Christian Ringler, Jin Young Lee, Nabora S. Reyes, Ritusree Biswas, Sofia E. Caryotakis, Mélia Magnen, Pedro Ruivo, Vincent C. Auyeung, Mark R. Looney et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  13. Additional file 1 of T cell expressions of aberrant gene signatures and Co-inhibitory receptors (Co-IRs) as predictors of renal damage and lupus disease activity
    Wang, Chin-Man, Jan Wu, Yeong-Jian, Zheng, Jian-Wen, Huang, Li Yu, Tan, Keng Poo, Chen, Ji-Yih · 2024 · Figshare
  14. Additional file 1 of Poly-γ-glutamic acid/Alum adjuvanted pH1N1 vaccine-immunized aged mice exhibit a significant increase in vaccine efficacy with a decrease in age-associated CD8+ T cell proportion in splenocytes
    Yang Jihyun, Kim, Jaemoo, Chaewon Kwak, Ha Ryoung Poo · 2022 · Figshare
  15. Aging-induced hepatocyte CD44 drives IL6/STAT3 signaling and associates with impaired neighboring T cell function
    Armin Gandhi, Kathryn Lande, Yichen Li, Filipe Araujo Hoffmann, Michael LaPorte, Shirong Tan, Garrett Evensen, Benji Portillo, Marcos G. Teneche, Rouven Arnold et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  16. Human Immunodeficiency Virus–Associated Proteomic Signature of Myocardial Fibrosis and Incident Heart Failure
    Tess E. Peterson, Virginia Shalkey Hahn, Ruin Moaddel, Min Zhu, Jinshui Fan, Supriyo De, Sabina Haberlen, Frank Joseph Palella, Michael W Plankey, Joel S. Bader et al. · 2026 · The Journal of Infectious Diseases
  17. The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential
    Hanqing He, Jianwei Wang · 2026 · Aging and Cancer
  18. T Cell Exhaustion: Phenomenon, Diagnostic and Prognostic Significance, Age-Related Features, and Correction in Lung Cancer
    Е. G. Skurikhin, M. A. Zhukova, E. S. Pan, N. N. Ermakova, Irina L. Zharkikh, A. M. Dygai · 2025 · Bulletin of Experimental Biology and Medicine
  19. Study of NKG2A+ and NKG2C+ CD8+ T cells in progressive and non-progressive HIV-1 and HIV-2 infections
    Aurelio Orta Resendiz · 2023 · theses.fr (ABES)
  20. Regulator of G protein signaling 10: a critical regulator of chronic systemic inflammation in parkinson’s disease
    Janna E. Jernigan, Kelly B. Menees, Malú G. Tansey · 2026 · Journal of Neuroinflammation
  21. Smoking accelerates immunosenescence in multiple sclerosis
    Meerah Khan, Ekdanai Uawithya, Joshua S Mytych, Ismail Muwenda, Megan Reidy, Robert C. Axtell, Yang Mao‐Draayer · 2026 · Frontiers in Immunology
  22. 18F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography (FDG PET/CT) in the Characterization of Massive Cardiac Infiltration by Peripheral T-cell Lymphoma, Not Otherwise Specified (PTCL-NOS)
    Rodolfo A Del Corral Vazquez, Jorge M Schalch, José Antonio Serna Macías, Emmanuel Francisco Murguía Lugo · 2026 · Cureus
  23. Immunosenescence modulates radiation-induced anti-tumor immunity: implications for personalized immuno-oncology
    Christoph Reinhold Arnold, Julian Mangesius, Birgit Weinberger, Iana Portnaia, Antonio Santacroce, Ute Ganswindt, Alexander Muacevic · 2026 · Frontiers in Immunology
  24. Integrated Analysis of Hematopoietic Changes Following Heterochronic Bone Marrow Transplantation Between Young and Aged Mice
    José A. Bejarano-García, Melanie Nufer, Rocío Caracuel-García, Teresa Caballero‐Velázquez, Alfonso Rodríguez Gil, Alicia Jordano Jimenes, Raquel Muñoz, Jose Ignacio Piruat, José Antonio Pérez‐Simón · 2026 · Transplantation and Cellular Therapy
  25. iPSC-Derived T and CAR-T Cells of Distinct Phenotypes: Current Protocols, Challenges and Potential for Cancer Treatment
    M. A. Maiak, Anna Sergeevna Efremova, Tatiana Budagova, Мокроусова Диана Олеговна, Dmitry Vadimovich Goldshtein · 2026 · Cells