Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo

Wang, Yu‐Chen; Lee, An‐Sheng; Lu, Long‐Sheng; Ke, Liang‐Yin; Chen, Wei‐Yu; Dong, Jian‐Wen; Lu, Jonathan; Chen, Zhenping; Chu, Chih‐Sheng; Chan, Hua‐Chen; Kuzan, Taha Y.; Tsai, Ming‐Hsien; Hsu, Wen‐Li; Dixon, Richard A. F.; Sawamura, Tatsuya; Chang, Kuan‐Cheng; Chen, Chu‐Huang

doi:10.1111/acel.12792

Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo

Summary Dysregulation of plasma lipids is associated with age‐related cardiovascular diseases. L5, the most electronegative subfraction of chromatographically resolved low‐density lipoprotein (LDL), induces endothelial dysfunction, whereas the least electronegative subfraction, L1, does not. In t…