Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice

Elmore, Monica R. P., Hohsfield, Lindsay A., Kramár, Enikö A., Soreq, Lilach, Lee, Rafael J., Pham, Stephanie T., Najafi, Allison R., Spangenberg, Elizabeth E. +3 more·2018·Aging Cell
DOI 10.1111/acel.12832

Cited by (377)

Items 301–377 of 377

  1. Gene Expression Changes in the Human Brain Upon Aging
    Lilach Soreq · 2023 · Journal of Neurology Research Review & Reports
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  11. A restarted life: Resetting microglia innate immune memory
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  12. Expression profile of long noncoding RNAs in post-stroke aphasia
    Linazi Gu, Caili Ren, Mei Qu, Hui Meng Chang, Yanling Xi · 2025 · Frontiers in Neurology
  13. Microglial plasticity across development mediates infantile amnesia
    Erika Stewart, Louisa G. Zielke, Gabrielle Guillaume, Anne De Boer, Sarah D. Power, Tomás J. Ryan · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  14. Short-term microglia depletion via CSF-1R inhibition promotes functional network reorganization and motor recovery after cortical ischemia
    Sara Isla Cainzos, Fanny Quandt, Malte Borggrewe, Hanna-Marie Altjohann, Tim Ullrich Magnus, Jonatan Biskamp · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  15. The role of donor source in determining neurological outcomes after microglial replacement
    Emma A Schindhelm, Troy C. Lund · 2025 · Molecular Therapy
  16. Advanced age and lipopolysaccharide influence behavioral and neurodegenerative features in LRRK2 G2019S knock-in mice
    Anuroopa Dinesh, Teresa Fortin, Hongyu Sun, Shawn P. Hayley · 2025 · Behavioural Brain Research
  17. Additional file 3 of Distinguishing the effects of systemic CSF1R inhibition by PLX3397 on microglia and peripheral immune cells
    Akhabue K. Okojie, Joseph O. Uweru, Morgan Coburn, Li, Sihan, Vivian D. Cao-Dao, Ukpong B. Eyo · 2024 · Figshare
  18. Additional file 1 of Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition
    Anna C. Stoll, Kemp, Christopher J., Joseph R. Patterson, Michael Kubik, Nathan C. Kuhn, Matthew J. Benskey, Megan F. Duffy, Kelvin C. Luk, Sortwell, Caryl E. · 2024 · Figshare
  19. Additional file 5 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
    Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
  20. Additional file 2 of Repopulated microglia induce expression of Cxcl13 with differential changes in Tau phosphorylation but do not impact amyloid pathology
    Berke Karaahmet, Le, Linh, Monique S. Mendes, Ania Katarzyna Majewska, M. Kerry O’Banion · 2022 · Figshare
  21. Additional file 4 of Repopulated microglia induce expression of Cxcl13 with differential changes in Tau phosphorylation but do not impact amyloid pathology
    Berke Karaahmet, Le, Linh, Monique S. Mendes, Ania Katarzyna Majewska, M. Kerry O’Banion · 2022 · Figshare
  22. Additional file 10 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
    Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
  23. Additional file 1 of Distinguishing the effects of systemic CSF1R inhibition by PLX3397 on microglia and peripheral immune cells
    Akhabue K. Okojie, Joseph O. Uweru, Morgan Coburn, Li, Sihan, Vivian D. Cao-Dao, Ukpong B. Eyo · 2024 · Figshare
  24. Additional file 1 of Repopulated microglia induce expression of Cxcl13 with differential changes in Tau phosphorylation but do not impact amyloid pathology
    Berke Karaahmet, Le, Linh, Monique S. Mendes, Ania Katarzyna Majewska, M. Kerry O’Banion · 2022 · Figshare
  25. Additional file 1 of Microglial deletion and inhibition alleviate behavior of post-traumatic stress disorder in mice
    Li, Shuoshuo, Liao, Yajin, Dong, Yuan, Li, Xiaoheng, Li, Jun, Cheng, Yong, Cheng, Jinbo, Yuan, Zengqiang · 2021 · Figshare
  26. Additional file 1 of Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice
    Kristina Berve, West, Brian L., Rudolf Martini, Janos Groh · 2020 · Figshare
  27. Additional file 8 of Repopulated microglia induce expression of Cxcl13 with differential changes in Tau phosphorylation but do not impact amyloid pathology
    Berke Karaahmet, Le, Linh, Monique S. Mendes, Ania Katarzyna Majewska, M. Kerry O’Banion · 2022 · Figshare
  28. Additional file 5 of Repopulated microglia induce expression of Cxcl13 with differential changes in Tau phosphorylation but do not impact amyloid pathology
    Berke Karaahmet, Le, Linh, Monique S. Mendes, Ania Katarzyna Majewska, M. Kerry O’Banion · 2022 · Figshare
  29. Additional file 6 of Repopulated microglia induce expression of Cxcl13 with differential changes in Tau phosphorylation but do not impact amyloid pathology
    Berke Karaahmet, Le, Linh, Monique S. Mendes, Ania Katarzyna Majewska, M. Kerry O’Banion · 2022 · Figshare
  30. Additional file 2 of Distinguishing the effects of systemic CSF1R inhibition by PLX3397 on microglia and peripheral immune cells
    Akhabue K. Okojie, Joseph O. Uweru, Morgan Coburn, Li, Sihan, Vivian D. Cao-Dao, Ukpong B. Eyo · 2024 · Figshare
  31. Additional file 17 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
    Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
  32. Additional file 1 of Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis
    Nils Mein, Nikolai von Stackelberg, Jonathan Wickel, Geis, Christian, Chung, Ha-Yeun · 2023 · Figshare
  33. Additional file 7 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
    Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
  34. Additional file 2 of Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition
    Anna C. Stoll, Kemp, Christopher J., Joseph R. Patterson, Michael Kubik, Nathan C. Kuhn, Matthew J. Benskey, Megan F. Duffy, Kelvin C. Luk, Sortwell, Caryl E. · 2024 · Figshare
  35. Additional file 3 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
    Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
  36. Additional file 16 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
    Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
  37. Additional file 18 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
    Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
  38. Additional file 1 of Effects of long-term and brain-wide colonization of peripheral bone marrow-derived myeloid cells in the CNS
    Lindsay A. Hohsfield, Allison R. Najafi, Yasamine Ghorbanian, Neelakshi Soni, Edna E. Hingco, Kim, Sung Jin, Ayer Darling Jue, Swarup, Vivek, Mathew A. Inlay, Kim N. Green · 2020 · Figshare
  39. Additional file 12 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
    Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
  40. Additional file 3 of Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition
    Anna C. Stoll, Christopher J. Kemp, Joseph R. Patterson, Michael Kubik, Nathan C. Kuhn, Matthew J. Benskey, Megan F. Duffy, Kelvin C. Luk, Sortwell, Caryl E. · 2024 · Figshare
  41. Additional file 5 of Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition
    Anna C. Stoll, Kemp, Christopher J., Joseph R. Patterson, Michael Kubik, Nathan C. Kuhn, Matthew J. Benskey, Megan F. Duffy, Kelvin C. Luk, Sortwell, Caryl E. · 2024 · Figshare
  42. Additional file 6 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
    Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
  43. Additional file 7 of Repopulated microglia induce expression of Cxcl13 with differential changes in Tau phosphorylation but do not impact amyloid pathology
    Berke Karaahmet, Le, Linh, Monique S. Mendes, Ania Katarzyna Majewska, M. Kerry O’Banion · 2022 · Figshare
  44. Additional file 10 of Repopulated microglia induce expression of Cxcl13 with differential changes in Tau phosphorylation but do not impact amyloid pathology
    Berke Karaahmet, Le, Linh, Monique S. Mendes, Ania Katarzyna Majewska, M. Kerry O’Banion · 2022 · Figshare
  45. Additional file 1 of Early postnatal microglial ablation in the Ccdc39 mouse model reveals adverse effects on brain development and in neonatal hydrocephalus
    Farrah N. Brown, Eri Iwasawa, Crystal Shula, Elizabeth M. Fugate, Diana M. Lindquist, Francesco T. Mangano, June Goto · 2023 · Figshare
  46. Additional file 2 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
    Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
  47. Additional file 9 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
    Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
  48. Additional file 14 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
    Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
  49. Additional file 3 of Repopulated microglia induce expression of Cxcl13 with differential changes in Tau phosphorylation but do not impact amyloid pathology
    Berke Karaahmet, Le, Linh, Monique S. Mendes, Ania Katarzyna Majewska, M. Kerry O’Banion · 2022 · Figshare
  50. Additional file 9 of Repopulated microglia induce expression of Cxcl13 with differential changes in Tau phosphorylation but do not impact amyloid pathology
    Berke Karaahmet, Le, Linh, Monique S. Mendes, Ania Katarzyna Majewska, M. Kerry O’Banion · 2022 · Figshare
  51. Additional file 13 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
    Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
  52. Additional file 15 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
    Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
  53. Additional file 4 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
    Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
  54. Additional file 8 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
    Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
  55. Additional file 4 of Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition
    Anna C. Stoll, Kemp, Christopher J., Joseph R. Patterson, Michael Kubik, Nathan C. Kuhn, Matthew J. Benskey, Megan F. Duffy, Kelvin C. Luk, Sortwell, Caryl E. · 2024 · Figshare
  56. Additional file 11 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
    Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
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