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Cited by 75Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and Therapy

Aging shifts mitochondrial dynamics toward fission to promote germline stem cell loss.

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Amartuvshin, Oyundari, Lin, Chi‐Hung, Hsu, Shao‐Chun, Kao, Shih‐Han, Chen, Alvin, Tang, Wei‐Chun, Chou, Han‐Lin, Chang, Dong‐Lin +9 more·2020·Aging Cell
DOI 10.1111/acel.13191PMC PMC7431834
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Abstract

Changes in mitochondrial dynamics (fusion and fission) are known to occur during stem cell differentiation; however, the role of this phenomenon in tissue aging remains unclear. Here, we report that mitochondrial dynamics are shifted toward fission during aging of Drosophila ovarian germline stem cells (GSCs), and this shift contributes to aging‐related GSC loss. We found that as GSCs age, mitochondrial fragmentation and expression of the mitochondrial fission regulator, Dynamin‐related protein (Drp1), are both increased, while mitochondrial membrane potential is reduced. Moreover, preventing mitochondrial fusion in GSCs results in highly fragmented depolarized mitochondria, decreased BMP stemness signaling, impaired fatty acid metabolism, and GSC loss. Conversely, forcing mitochondrial elongation promotes GSC attachment to the niche. Importantly, maintenance of aging GSCs can be enhanced by suppressing Drp1 expression to prevent mitochondrial fission or treating with rapamycin, which is known to promote autophagy via TOR inhibition. Overall, our results show that mitochondrial dynamics are altered during physiological aging, affecting stem cell homeostasis via coordinated changes in stemness signaling, niche contact, and cellular metabolism. Such effects may also be highly relevant to other stem cell types and aging‐induced tissue degeneration.

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  • Mitochondrial dynamics are altered during physiological aging, affecting cell homeostasis via coordinated changes in cell signaling.

    “These results demonstrate that mitochondrial dynamics are altered during physiological aging, affecting cell homeostasis via coordinated changes in cell signaling (Amartuvshin et al., 2020).”

    From Aging promotes an increase in mitochondrial fragmentation in astrocytes (2024) · cites this paper as Amartuvshin et al., 2020

    The Abstract reports that mitochondrial dynamics shift during physiological aging of Drosophila ovarian germline stem cells and affect stem cell homeostasis. The claim broadens this to cell homeostasis generally and reduces the reported mechanisms—stemness signaling, niche contact, and cellular metabolism—to cell signaling alone. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • In Drosophila ovarian germline stem cells as they age, mitochondrial fragmentation and DRP1 expression are both increased, while mitochondrial membrane potential is reduced.

    “Consistent with our findings, in Drosophila ovarian germline stem cells as they age, mitochondrial fragmentation and the expression of the mitochondrial fission regulator, DRP1, are both increased, while mitochondrial membrane potential is reduced.”

    From Aging promotes an increase in mitochondrial fragmentation in astrocytes (2024) · cites this paper as Amartuvshin et al., 2020

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Cited by

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Authors
Amartuvshin, O., Lin, C., Hsu, S., Kao, S., Chen, A., Tang, W., Chou, H., Chang, D., Hsu, Y., Hsiao, B., Rastegari, E., Lin, K., Wang, Y., Yao, C., Chen, G., Chen, B., & Hsu, H.
Affiliations
  • Institute of Cellular and Organismic Biology, Academia Sinica (TW)
  • Research Center for Applied Science, Academia Sinica (TW)
  • National Taiwan Normal University (TW)
  • Molecular and Cell Biology Taiwan International Graduate Program Academia Sinica Taipei Taiwan
  • Institute of Biological Chemistry, Academia Sinica (TW)
Corresponding author
Hsu, Hwei‐Jan
ORCID
Venue
Aging Cell
Publisher
Wiley
Published
2020-07-14
Volume
19
Issue
8
Pages
e13191-e13191
ISSN
  • 1474-9718 (ISSN-L)
  • 1474-9726
DOI
10.1111/acel.13191
PMC
PMC7431834
OpenAlex
W3043370561
Cited by
75
References
7
Citations by year
2026: 12 · 2025: 11 · 2024: 18 · 2023: 9 · 2022: 12 · 2021: 11 · 2020: 1
FWCI
2.64
Type
journal article
Language
en
Open access
Licence
Locations
  • Aging Cell (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Academia Sinica
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
mitochondrial dynamics, mitochondrial fission, mitochondrial fusion, germline stem cells, tissue aging, Drp1, mitochondrial membrane potential, BMP signaling, stemness, fatty acid metabolism, stem cell niche, rapamycin, autophagy, TOR signaling, Drosophila ovary
MeSH terms
Adult Germline Stem Cells, Animals, Cell Differentiation, Drosophila, Female, Male, Stem Cells, Signal Transduction, Cell Proliferation, Mitochondrial Dynamics

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