Inhibition of the cGAS‐STING pathway ameliorates the premature senescence hallmarks of Ataxia‐Telangiectasia brain organoids

Aguado, Julio; Chaggar, Harman K.; Gómez‐Inclán, Cecilia; Shaker, Mohammed R.; Leeson, Hannah C.; Mackay‐Sim, Alan; Wolvetang, Ernst J.

doi:10.1111/acel.13468

Inhibition of the cGAS‐STING pathway ameliorates the premature senescence hallmarks of Ataxia‐Telangiectasia brain organoids

Ataxia‐telangiectasia (A‐T) is a genetic disorder caused by the lack of functional ATM kinase. A‐T is characterized by chronic inflammation, neurodegeneration and premature ageing features that are associated with increased genome instability, nuclear shape alterations, micronuclei accumulation, …