Loss of lamin‐B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus

Matias, Isadora; Diniz, Luan Pereira; Damico, Isabella Vivarini; Araujo, Ana Paula Bergamo; Neves, Laís da Silva; Vargas, Gabriele; Leite, Renata E. P.; Suemoto, Claudia K.; Nitrini, Ricardo; Jacob‐Filho, Wilson; Grinberg, Lea T.; Hol, Elly M.; Middeldorp, Jinte; Gomes, Flávia Carvalho Alcantara

doi:10.1111/acel.13521

Loss of lamin‐B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus

The increase in senescent cells in tissues, including the brain, is a general feature of normal aging and age‐related pathologies. Senescent cells exhibit a specific phenotype, which includes an altered nuclear morphology and transcriptomic changes. Astrocytes undergo senescence in vitro and in a…