The DOI matches its Crossref record; 280 of the 280 references it cites were found in a registry or an index.
Alcohol Use and Human Immunodeficiency Virus (HIV) Infection: Current Knowledge, Implications, and Future Directions
Open accessAbstract
Alcohol use is common among people living with human immunodeficiency virus (HIV). In this narrative review, we describe literature regarding alcohol's impact on transmission, care, coinfections, and comorbidities that are common among people living with HIV (PLWH), as well as literature regarding interventions to address alcohol use and its influences among PLWH. This narrative review identifies alcohol use as a risk factor for HIV transmission, as well as a factor impacting the clinical manifestations and management of HIV. Alcohol use appears to have additive and potentially synergistic effects on common HIV‐related comorbidities. We find that interventions to modify drinking and improve HIV‐related risks and outcomes have had limited success to date, and we recommend research in several areas. Consistent with Office of AIDS Research/National Institutes of Health priorities, we suggest research to better understand how and at what levels alcohol influences comorbid conditions among PLWH, to elucidate the mechanisms by which alcohol use is impacting comorbidities, and to understand whether decreases in alcohol use improve HIV‐relevant outcomes. This should include studies regarding whether state‐of‐the‐art medications used to treat common coinfections are safe for PLWH who drink alcohol. We recommend that future research among PLWH include validated self‐report measures of alcohol use and/or biological measurements, ideally both. Additionally, subgroup variation in associations should be identified to ensure that the risks of particularly vulnerable populations are understood. This body of research should serve as a foundation for a next generation of intervention studies to address alcohol use from transmission to treatment of HIV. Intervention studies should inform implementation efforts to improve provision of alcohol‐related interventions and treatments for PLWH in healthcare settings. By making further progress on understanding how alcohol use affects PLWH in the era of HIV as a chronic condition, this research should inform how we can mitigate transmission, achieve viral suppression, and avoid exacerbating common comorbidities of HIV and alcohol use and make progress toward the 90‐90‐90 goals for engagement in the HIV treatment cascade.
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“However, since 2008, considerable new scientific evidence has emerged which supports a causal role of alcohol.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [99]
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“These include clear evidence that heavy drinking or alcohol use disorders are associated with viral load increases and/or CD4 count declines, mediated partly by treatment adherence and partly by the pharmacological interactions with anti‐retroviral and other medications to treat comorbidities (for mechanisms see 99, 128, 130, 132, 133, 134; for pharmacological interactions see 135, 136).”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [99]
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The relationship between different dimensions of alcohol use and the burden of disease—an update
Rehm, J., Gmel, G. E., Gmel, G., Hasan, O. S. M., Imtiaz, S., Popova, S., Probst, C., Roerecke, M., Room, R., Samokhvalov, A. V., et al. (2017) · Addiction · doi:10.1111/add.13757 · Cited by 1,204
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“These findings show that behavioral interventions addressing alcohol use can successfully reduce alcohol consumption and also improve HIV-related outcomes among PLWHA.”
BackgroundResultInfluential
Metadata
- Authors
- Williams, E. C., Hahn, J. A., Saitz, R., Bryant, K., Lira, M. C., & Samet, J. H.
- Affiliations
- University of Washington (US)
- University of California, San Francisco (US)
- Boston University (US)
- National Institutes of Health (US)
- Corresponding author
- Samet, Jeffrey H.
- ORCID
- Venue
- Alcoholism: Clinical and Experimental Research
- Publisher
- Wiley
- Published
- 2016-09-22
- Volume
- 40
- Issue
- 10
- Pages
- 2056-2072
- ISSN
- 0145-6008 (ISSN-L)
- 1530-0277
- PMC
- PMC5119641
- OpenAlex
- W2521342226
- Cited by
- 294
- References
- 280
- Citations by year
- 2026: 21 · 2025: 31 · 2024: 21 · 2023: 27 · 2022: 29 · 2021: 37 · 2020: 42 · 2019: 34 · 2018: 24 · 2017: 28
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alcoholism Clinical and Experimental Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (U01AA020784, U24AA020778, U01AA020780, U01AA020776, K24AA022586)
- Health Services Research and Development (CDA 12‐276)
- Topics
- Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- alcohol consumption, HIV infection, people living with HIV, HIV transmission, HIV coinfection, HIV comorbidities, alcohol interventions, antiretroviral drug safety, viral suppression, 90-90-90 targets, vulnerable populations
- MeSH terms
- Alcohol Drinking, Humans, Research, HIV Infections, Comorbidity, Coinfection
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