Association of intracortical myelin and cognitive function in bipolar I disorder
Abstract
Objective Although cognitive dysfunction persists through affective and euthymic states in bipolar disorder (BD), its neurobiological correlates remain undetermined. We explore whole-cortex intracortical myelin (ICM) and cognition in BD-I and controls. Methods T 1 -weighted images (3T) optimized for ICM measurement were analyzed using a surface-based approach. MRI signal was sampled at cortical mid-depth. Cognitive performance was measured via standardized computerized battery and paper-and-pencil Trails B. Results ICM was associated with verbal memory (VM) in BD throughout a cortical network identified with pertinence to VM function, with strongest effects in left caudal middle temporal cortex and left dorsolateral prefrontal cortex (P corrected Conclusion This is the first study to show VM association with ICM in BD. ICM has been implicated in the integrity of neural connections and neural synchrony. VM dysfunction is one of the most replicated cognitive abnormalities in BD. Therefore, these results provide a novel mechanism for understanding cognitive dysfunction in BD, which can aid in the development of targeted therapeutics to improve cognitive outcomes in BD.
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This result is consistent with the previous observation that deficiency in PRRC2A reduces the oligodendroglia population in the brain and induces hypomyelination, which leads to impaired locomotive and cognitive functions.
“This result is consistent with the previous observation that deficiency in PRRC2A reduces the oligodendroglia population in the brain and induces hypomyelination, which leads to an impaired locomotive and cognitive functions [74–76].”
From Distinct sex-specific DNA methylation differences in Alzheimer’s disease (2022) · cites this paper as [76]
Cites
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Early-Onset Bipolar Disorder and Treatment Delay Are Risk Factors for Poor Outcome in Adulthood
Post, R. M., Leverich, G. S., Kupka, R. W., Keck, P. E., McElroy, S. L., Altshuler, L. L., Frye, M. A., Luckenbaugh, D. A., Rowe, M., Grunze, H., et al. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04994yel · Cited by 360 · see citing works
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Distinct sex-specific DNA methylation differences in Alzheimer’s disease
C. Silva, T., Zhang, W., Young, J. I., Gomez, L., Schmidt, M. A., Varma, A., Chen, X. S., Martin, E. R., & Wang, L. (2022) · Alzheimer's Research & Therapy · doi:10.1186/s13195-022-01070-z · Cited by 33 · see citing works
- Authors
- Sehmbi, M., Rowley, C. D., Minuzzi, L., Kapczinski, F., Steiner, M., Sassi, R. B., Bock, N. A., & Frey, B. N.
- Affiliations
- McMaster University (CA)
- St. Joseph’s Healthcare Hamilton (CA)
- Corresponding author
- Frey, B. N.
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2018-03-13
- Volume
- 138
- Issue
- 1
- Pages
- 62-72
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W2793452580
- Cited by
- 17
- References
- 4
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 3
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- McMaster University
- Brain and Behavior Research Foundation (22200)
- Canadian Institutes of Health Research
- Hamilton Health Sciences
- Ontario Brain Institute
- Ontario Mental Health Foundation
- Physicians' Services Incorporated Foundation
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- bipolar I disorder, cognitive impairment, visual memory, executive function, processing speed, reaction time, white matter integrity, cortical myelination, neurometabolism
- MeSH terms
- Adolescent, Adult, Bipolar Disorder, Cerebral Cortex, Female, Humans, Male, Middle Aged, Myelin Sheath, Young Adult, Cognitive Dysfunction
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