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Placental expression of lysophosphatidic acid receptors in normal pregnancy and preeclampsia
Abstract
Problem: Recent advances in lipid research have revealed that impairments in lipid mediator signaling can be involved in the pathoetiology of a variety of diseases. We previously reported aberrant expression of autotaxin, a key enzyme for lysophosphatidic acid (LPA) production, in placentas from women with preeclampsia. The present study aimed to further explore the involvement of LPA signaling in the pathoetiology of preeclampsia. Method of study: Term placentas were obtained from deliveries after uncomplicated pregnancy (n = 18) and those complicated by preeclampsia (n = 24). First‐trimester placental tissues were collected after elective terminations of pregnancy (n = 20). Placental expression of the six identified LPARs (LPAR1‐6) was analyzed at protein and mRNA levels. Results: In normal pregnancy, the mRNA expression levels of all LPARs except LPAR4 were significantly higher in term. Levels of mRNA encoding LPAR2‐5 were significantly increased in preeclampsia placentas compared with those in the normal term placentas. Using Western immunoblotting, only LPAR3 was noted to be increased at the protein level in placentas from preeclamptic pregnancies. This was validated by immunohistochemistry. Conclusion: In summary, the placental expression of LPARs, particularly LPAR3, is enhanced in preeclampsia, suggesting that disturbances in placental LPA signaling may be involved in the pathogenesis of preeclampsia.
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The dosing branch predicted individualized GC regimens with sub-milligram precision, outperforming static gestational age-based protocols (12 mg × 2) that neglect inter-individual variation.
“Third, by integrating serial multimodal features with dynamic metabolomic scores, the dosing branch predicted individualized GC regimens with sub-milligram precision, outperforming static gestational age-based protocols (12 mg × 2) that neglect inter-individual variation (19, 20).”
From Placenta-pulmonary coupling-guided multimodal AI for fetal lung maturity staging and individualized glucocorticoid therapy (2026) · cites this paper as [20]
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Metadata
- Authors
- Fujii, T., Nagamatsu, T., Schust, D. J., Ichikawa, M., Kumasawa, K., Yabe, S., Iriyama, T., Hirota, Y., Osuga, Y., Aoki, J., Yatomi, Y., & Fujii, T.
- Affiliations
- The University of Tokyo (JP)
- University of Missouri (US)
- Social Insurance Saitama Chuo Hospital (JP)
- Tohoku University (JP)
- Corresponding author
- Nagamatsu, Takeshi
- ORCID
- Venue
- American Journal of Reproductive Immunology
- Publisher
- Wiley
- Published
- 2019-08-16
- Volume
- 82
- Issue
- 5
- Pages
- e13176-e13176
- ISSN
- 0271-7352 (ISSN-L)
- 1046-7408
- 1600-0897
- OpenAlex
- W2965931650
- Cited by
- 19
- References
- 31
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 8 · 2020: 2
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Reproductive Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (18H02943, 15H04979)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- lysophosphatidic acid, lysophosphatidic acid receptor, LPAR3, preeclampsia, placenta, autotaxin, gene expression, pregnancy
- MeSH terms
- Adult, Female, Gene Expression Regulation, Humans, Placenta, Pre-Eclampsia, Pregnancy, Receptors, Lysophosphatidic Acid
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