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Cited by 45Transplantation: Methods and OutcomesNeonatal Respiratory Health ResearchOrgan Transplantation Techniques and Outcomes

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Phenotyping Chronic Lung Allograft Dysfunction Using Body Plethysmography and Computed Tomography

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Suhling, H., Dettmer, S., Greer, M., Fuehner, T., Avsar, M., Haverich, A., Welte, T., Gottlieb, J.·2016·American Journal of Transplantation
DOI 10.1111/ajt.13876
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Abstract

Restrictive subtype of chronic lung allograft dysfunction (CLAD) was recently described after lung transplantation. This study compares different definitions of a restrictive phenotype in CLAD patients and impact on survival. Eighty-nine CLAD patients out of 1191 screened patients (September 1987 to July 2012) were included as complete longitudinal lung volume measurements and chest computed tomography (CT) after CLAD onset was available. CT findings and lung volumes were quantified and survival was calculated for distinctive groups and predictive factors for worse survival were investigated. Graft survival in patients with total lung capacity (TLC) between 90% and 81% of baseline (BL) (n = 13, 15%) in CLAD course was similar to those with TLC >90% BL (n = 64, 56%; log-rank test p = 0.9). Twelve patients (13%) developed a TLC ≤80% BL and 10 (11%) had significant parenchymal changes on CT, of whom 6 (46%) also had TLC ≤80% BL. CT changes correlated with TLC ≤80% BL (Φ-coefficient = 0.48, p = 0.001). Patients with either TLC ≤80% or significant CT changes (n = 16, 18%) had a significantly reduced survival (log-rank p < 0.001). Forced vital capacity loss at CLAD onset was associated with poorer survival but did not correlate with the TLC or CT changes. A restrictive subtype of CLAD may be defined by either TLC ≤80% BL or severe parenchymal changes on chest CT.

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Research works printed but not linked: 21

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Metadata

Authors
Suhling, H., Dettmer, S., Greer, M., Fuehner, T., Avsar, M., Haverich, A., Welte, T., & Gottlieb, J.
Affiliations
Medizinische Hochschule Hannover (DE)
Corresponding author
Suhling, H.
ORCID
Venue
American Journal of Transplantation
Publisher
Elsevier BV
Published
2016-11
Volume
16
Issue
11
Pages
3163-3170
ISSN
1600-6135 (ISSN-L)
DOI
10.1111/ajt.13876
OpenAlex
W2403838786
Cited by
45
References
0
Citations by year
2026: 2 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 9 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 7 · 2016: 4
FWCI
9.23
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Transplantation (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
  • Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
Keywords
chronic lung allograft dysfunction, lung transplantation, total lung capacity, body plethysmography, chest CT, graft survival
MeSH terms
Adult, Female, Graft Rejection, Humans, Lung Diseases, Male, Middle Aged, Phenotype, Plethysmography, Prognosis, Retrospective Studies, Risk Factors, Tomography, X-Ray Computed, Survival Rate, Lung Transplantation, Primary Graft Dysfunction, Allografts

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