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Cited by 95Neutrophil, Myeloperoxidase and Oxidative MechanismsTransplantation: Methods and OutcomesInflammation biomarkers and pathways

The Role of Neutrophils in Transplanted Organs

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Scozzi, D., Ibrahim, M., Menna, C., Krupnick, A.S., Kreisel, D., Gelman, A.E.·2017·American Journal of Transplantation
DOI 10.1111/ajt.13940PMC PMC5183560
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Abstract

Neutrophils are often viewed as nonspecialized effector cells whose presence is a simple indicator of tissue inflammation. There is new evidence that neutrophils exist in subsets and have specialized effector functions that include extracellular trap generation and the stimulation of angiogenesis. The application of intravital imaging to transplanted organs has revealed novel requirements for neutrophil trafficking into graft tissue and has illuminated direct interactions between neutrophils and other leukocytes that promote alloimmunity. Paradoxically, retaining some neutrophilia may be important to induce or maintain tolerance. Neutrophils can stimulate anti-inflammatory signals in other phagocytes and release molecules that inhibit T cell activation. In this article, we will review the available evidence of how neutrophils regulate acute and chronic inflammation in transplanted organs and discuss the possibility of targeting these cells to promote tolerance.

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  • Neutrophils are first responders taking part in phagocytosis and degranulation after infiltration into implanted biomaterials.

    “neutrophils are the first responders taking part in phagocytosis and degranulation after infiltration into implanted biomaterials13,14.”

    From Bioengineered liver crosslinked with nano-graphene oxide enables efficient liver regeneration via MMP suppression and immunomodulation (2023) · cites this paper as [13]

    The Introduction says neutrophils are usually the first leukocytes to infiltrate transplanted organs, and Acute Injury describes their release of tissue-digesting enzymes after leaving the vasculature. Those passages concern transplanted organs, not implanted biomaterials, and our copy does not establish that the infiltrating neutrophils perform phagocytosis there. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Cited by

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Authors
Scozzi, D., Ibrahim, M., Menna, C., Krupnick, A. S., Kreisel, D., & Gelman, A. E.
Affiliations
  • Washington University in St. Louis (US)
  • Sapienza University of Rome (IT)
Corresponding author
Gelman, A.E.
ORCID
Venue
American Journal of Transplantation
Publisher
Elsevier BV
Published
2017-02
Volume
17
Issue
2
Pages
328-335
ISSN
1600-6135 (ISSN-L)
DOI
10.1111/ajt.13940
PMC
PMC5183560
OpenAlex
W2466662373
Cited by
95
References
1
Citations by year
2026: 7 · 2025: 10 · 2024: 14 · 2023: 14 · 2022: 12 · 2021: 12 · 2020: 4 · 2019: 11 · 2018: 10 · 2016: 1
FWCI
0.71
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Transplantation (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Funders
  • National Heart, Lung, and Blood Institute (R01HL113436, R01HL121218, R01HL094601)
  • National Institute of Allergy and Infectious Diseases (R21AI119506, P01AI116501)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
  • Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords
neutrophils, organ transplantation, alloimmunity, graft rejection, neutrophil subsets, neutrophil extracellular traps, angiogenesis, neutrophil trafficking, intravital imaging, transplantation tolerance, inflammation, T cell activation inhibition, anti-inflammatory signaling
MeSH terms
Animals, Graft Rejection, Humans, Immunity, Innate, Neutrophils, Organ Transplantation

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