Efficacy and safety of D. pteronyssinus immunotherapy in local allergic rhinitis: a double‐blind placebo‐controlled clinical trial
Abstract
The effects of allergen immunotherapy ( AIT ) on local allergic rhinitis ( LAR ) are largely unknown. We conducted the first randomized, double‐blind, placebo‐controlled ( DBPC ), phase II trial of D. pteronyssinus ( DP ) subcutaneous AIT ( DP ‐ AIT ) on LAR (clinicaltrials.gov identifier: NCT 02123316). Thirty‐six LAR patients received Pangramin PLUS DP or placebo for 24 months. The primary endpoints were symptoms, medication scores, and medication‐free days. The secondary included skin test, serum specific IgE and IgG4, nasal allergen provocation test ( NAPT ), and adverse events. AIT ‐ DP produced significant improvements in both primary and secondary endpoints vs placebo. After 12 months of AIT ‐ DP , we detected a significant and marked increase in allergen tolerance with negative NAPT in 50% of patients, and significant increases of serum sIgG 4. Immunotherapy was well tolerated; no systemic reactions were reported. This study demonstrated that AIT ‐ DP is a safe and clinically effective treatment for LAR , confirming that LAR is a new indication for AIT.
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Mite sublingual immunotherapy relieves nasal symptoms in patients with local allergic rhinitis.
“A clinical trial with mite SLIT demonstrated relief of nasal symptoms in addition to a negative nasal provocation result in 50% of patients with local allergic rhinitis [177].”
From Position Paper on Nasal Obstruction: Evaluation and Treatment (2018) · cites this paper as [177]
Mite sublingual immunotherapy results in a negative nasal provocation result in 50% of patients with local allergic rhinitis.
“A clinical trial with mite SLIT demonstrated relief of nasal symptoms in addition to a negative nasal provocation result in 50% of patients with local allergic rhinitis [177].”
From Position Paper on Nasal Obstruction: Evaluation and Treatment (2018) · cites this paper as [177]
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Position Paper on Nasal Obstruction: Evaluation and Treatment
SEAIC Rhinoconjunctivitis Committee & SEORL Rhinology, A., Valero, A., Navarro, A., del Cuvillo, A., Alobid, I., Benito, Jr., Colás, C., de los Santos, G., Fernández Liesa, R., García-Lliberós, A., et al. (2018) · Journal of Investigational Allergology and Clinical Immunology · doi:10.18176/jiaci.0232 · Cited by 76 · see citing works
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- Authors
- Rondón, C., Campo, P., Salas, M., Aranda, A., Molina, A., González, M., Galindo, L., Mayorga, C., Torres, M. J., & Blanca, M.
- Affiliations
- Hospital Regional Universitario de Málaga (ES)
- Allergy Unit IBIMA‐Regional University Hospital of Málaga UMA Malaga Spain
- Corresponding author
- Rondón, C.
- Venue
- Allergy
- Publisher
- Wiley
- Published
- 2016-04-13
- Volume
- 71
- Issue
- 7
- Pages
- 1057-1061
- ISSN
- 0105-4538 (ISSN-L)
- 1398-9995
- OpenAlex
- W2311528704
- Cited by
- 84
- References
- 5
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 11 · 2021: 10 · 2020: 13 · 2019: 8 · 2018: 10 · 2017: 8 · 2016: 2
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Allergy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Instituto de Salud Carlos III
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- allergen immunotherapy, house dust mites, Dermatophagoides pteronyssinus, local allergic rhinitis, subcutaneous immunotherapy, allergen tolerance, serum IgG4, nasal allergen provocation test, treatment safety
- MeSH terms
- Allergens, Animals, Desensitization, Immunologic, Humans, Treatment Outcome, Antigens, Dermatophagoides, Dermatophagoides pteronyssinus, Rhinitis, Allergic
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