Real-life study showing uncontrolled rhinosinusitis after sinus surgery in a tertiary referral centre
Open accessAbstract
RATIONALE: The European Position Paper on Sinusitis (EPOS) guidelines provide composite criteria to evaluate chronic rhinosinusitis (CRS) control, taking into consideration the severity of patients' symptoms, aspect of nasal mucosa and medical intake as parameters of CRS control. OBJECTIVES: To study the degree of CRS control using novel EPOS control criteria at 3-5 years after a functional endoscopic sinus surgery (FESS) and correlate these data to symptoms scores. METHODS: Adult CRS patients (n = 560) who had undergone bilateral FESS for chronic inflammatory sinonasal disease 3-5 years prior to the study were included. Patients received a postal questionnaire asking for control items according to EPOS control criteria, visual analogue scale (VAS) scores for total and individual sinonasal symptoms, sinonasal outcome test (SNOT)-22 and Short Form (SF)-36 questionnaires. MEASUREMENTS AND MAIN RESULTS: About 19.5% of CRS patients were well controlled, with 36.8% of patients being partly controlled and 43.7% uncontrolled. The levels of control corresponded to mean total VAS, SNOT-22 and SF-36 scores. Subgroup analysis revealed that female gender, aspirin intolerance and revision FESS were associated with higher prevalence of uncontrolled CRS, whereas allergy, asthma and smoking status did not alter the percentage of patients in each category of control. In 81 patients attending the outpatient clinic, nasal endoscopy changed classification in only four patients (4.9%). CONCLUSIONS: Based on the novel EPOS control criteria, at least 40% of CRS patients are uncontrolled at 3-5 years after FESS. Therefore, better treatment strategies leading to higher disease control are warranted in CRS care.
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Very long-term control leads to improvement in chronic rhinosinusitis with nasal polyps after surgery.
“Treatment with INCs should continue after surgery [226], and very long-term control leads to improvement [227].”
From Position Paper on Nasal Obstruction: Evaluation and Treatment (2018) · cites this paper as [227]
The Discussion (page unavailable) says many patients felt they had a higher level of control after surgery, which lends limited support to improvement. But it explicitly says this observational study did not evaluate improvement attributable to surgery. It does not show that very long-term control leads to improvement specifically in patients with nasal polyps. (LLM, conf=0.83)
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Cites
Global strategy for asthma management and prevention: GINA executive summary
Bateman, E. D., Hurd, S. S., Barnes, P. J., Bousquet, J., Drazen, J. M., FitzGerald, M., Gibson, P., Ohta, K., O'Byrne, P., Pedersen, S. E., et al. (2008) · European Respiratory Journal · doi:10.1183/09031936.00138707 · Cited by 3,203 · see citing works
Fokkens, W. J., Lund, V. J., Mullol, J., Bachert, C., Alobid, I., Baroody, F., Cohen, N., Cervin, A., Douglas, R., Gevaert, P., et al. (2012) · Rhinology journal · doi:10.4193/rhino12.000 · Cited by 2,387 · see citing works
Self-citationSchatz, M., Sorkness, C. A., Li, J. T., Marcus, P., Murray, J. J., Nathan, R. A., Kosinski, M., Pendergraft, T. B., & Jhingran, P. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.01.011 · Cited by 1,221 · see citing works
Akdis, C. A., Bachert, C., Cingi, C., Dykewicz, M. S., Hellings, P. W., Naclerio, R. M., Schleimer, R. P., & Ledford, D. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.02.036 · Cited by 538 · see citing works
Self-citationAlt, J. A., DeConde, A. S., Mace, J. C., Steele, T. O., Orlandi, R. R., & Smith, T. L. (2015) · JAMA Otolaryngology–Head & Neck Surgery · doi:10.1001/jamaoto.2015.1673 · Cited by 53 · see citing works
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Research works printed but not linked: 13
- [3]Bousquet J, Bachert C, Canonica GW, Casale TB, Cruz AA, Lockey RJ et al. Unmet needs in severe chronic upper airway disease (SCUAD). J Allergy Clin Immunol 2009; 124: 428– 433. 19660803
- [4]Hellings P, Fokkens WJ, Akdis C, Bachert C, Cingi C, de Dietz Loos D et al. Uncontrolled allergic rhinitis and chronic rhinosinusitis: where do we stand today? Allergy 2013; 68: 1– 7. 23025484
- [5]Prokopakis EP, Vlastos IM, Ferguson BJ, Scadding G, Kawauchi H, Georgalas C et al. SCUAD and chronic rhinosinusitis. Reinforcing hypothesis driven research in difficult cases. Rhinology 2014; 52: 3– 8. 24618621
- [7]Hopkins C, Gillett S, Slack R, Lund VJ, Browne JP. Psychometric validity of the 22‐item Sinonasal Outcome Test. Clin Otolaryngol 2009; 34: 447– 454. 19793277
- [8]Bousquet J, Combescure C, Neukirch F, Klossek JM, Méchin H, Daures JP et al. Visual analogue scales can asses the severity of rhinitis graded according to ARIA guidelines. Allergy 2007; 62: 367– 372. 17362246
- [9]Dietz de Loos DA, Segboer CL, Gevorgyan A, Fokkens WJ. Disease‐specifiec quality‐of‐life questionnaires in rhinitis and rhinosinusitis: reviez and evaluation. Curr Allergy Asthma Rep 2013; 13: 162– 170. 23299562
- [10]Hastan D, Fokkens WJ, Bachert C, Newson RB, Bislimovska J, Bockelbrink A et al. Chronic rhinosinusitis in Europe ‐ an underestimated disease. A GA2LEN Study. Allergy 2011; 66: 1216– 1223. 21605125
- [12]Vlaminck S, Vauterin T, Hellings PW, Jorissen M, Acke F, Van Cauwenberge P et al. The importance of local eosinophilia in the surgical outcome of chronic rhinosinusitis: a 3‐year prospective observational study. Am J Rhinol Allergy 2014; 28: 260– 264. 24980239
- [13]Bosteels C et al. Twelve‐year follow‐up study in patients with nasal polyposis after Functional Endoscopic Sinus Surgery, 2013 (dissertation) Available at: http://lib.ugent.be/fulltxt/RUG01/002/061/676/RUG01-002061676_2013_0001_AC.pdf.
- [14]Ragab SM, Lund VJ, Scadding G. Evaluation of the medical and surgical treatment of chronic rhinosinusitis: a prospective, randomised, controlled trial. Laryngoscope 2004; 114: 923– 930. 15126758
- [15]Hopkins C, Rudmik L, Lund VJ. The predictive value of the preoperative Sinonasal outcome test‐22 score in patients undergoing endoscopic sinus surgery for chronic rhinosinusitis. Laryngoscope 2015; 125: 1779– 1784. 25891944
- [17]Schaitkin B, May M, Shapiro A, Fucci M, Mester SJ. Endoscopic sinus surgery: 4‐year follow‐up on the first 100 patients. Laryngoscope 1993; 103: 1117– 1120. 8412447
- [18]Batra PS, Kern RC, Tripathi A, Conley DB, Ditto AM, Haines GK 3rd et al. Outcome analysis of endoscopic sinus surgery in patients with nasal polyps and asthma. Laryngoscope 2003; 113: 1703– 1706. 14520093
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Position Paper on Nasal Obstruction: Evaluation and Treatment
SEAIC Rhinoconjunctivitis Committee & SEORL Rhinology, A., Valero, A., Navarro, A., del Cuvillo, A., Alobid, I., Benito, Jr., Colás, C., de los Santos, G., Fernández Liesa, R., García-Lliberós, A., et al. (2018) · Journal of Investigational Allergology and Clinical Immunology · doi:10.18176/jiaci.0232 · Cited by 76 · see citing works
- Authors
- van der Veen, J., Seys, S. F., Timmermans, M., Levie, P., Jorissen, M., Fokkens, W. J., & Hellings, P. W.
- Affiliations
- Department of Otorhinolaryngology-Head and Neck Surgery; UZ Leuven; Leuven Belgium
- Universitair Ziekenhuis Leuven (BE)
- ENT Clinic Messidor; Brussels Belgium
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Hellings, P. W.
- Venue
- Allergy
- Publisher
- Wiley
- Published
- 2016-09-15
- Volume
- 72
- Issue
- 2
- Pages
- 282-290
- ISSN
- 0105-4538 (ISSN-L)
- PMC
- PMC5248621
- OpenAlex
- W2469742199
- Cited by
- 172
- References
- 5
- Citations by year
- 2026: 8 · 2025: 25 · 2024: 13 · 2023: 23 · 2022: 25 · 2021: 18 · 2020: 23 · 2019: 13 · 2018: 14 · 2017: 9 · 2016: 1
- FWCI
- 11.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Allergy (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Otorhinolaryngology › Sinusitis and nasal conditions
- Health Sciences › Medicine › Surgery › Nasal Surgery and Airway Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Keywords
- chronic rhinosinusitis, functional endoscopic sinus surgery, disease control, sinonasal symptoms, SNOT-22, SF-36, revision sinus surgery, aspirin intolerance, nasal endoscopy, long-term outcomes
- MeSH terms
- Adolescent, Adult, Aged, Belgium, Chronic Disease, Female, Humans, Male, Middle Aged, Paranasal Sinuses, Laparoscopy, Surveys and Questionnaires, Rhinitis, Sinusitis, Young Adult, Tertiary Care Centers
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