The DOI matches its Crossref record.
Therapeutic effect of capsaicin nasal treatment in patients with mixed rhinitis unresponsive to intranasal steroids
Open accessAbstract
Literature is convincing regarding the efficacy of capsaicin nasal treatment in idiopathic rhinitis (IR). However, up to 50% of IR patients do not meet the strict inclusion criteria of the trials conducted so far. As a consequence, the efficacy of capsaicin is unknown in a significant number of IR patients that do not meet the strict inclusion/exclusion criteria (J Allergy Clin Immunol. 2014;133:1332, J Allergy Clin Immunol. 2017; [Epub ahead of print]). “Mixed rhinitis” (MR) patients have more than one major etiologic factor involved in the mucosal pathology. We have no idea about the efficacy of capsaicin nasal spray in these patients nor about the time interval to seek a second application. We report here that capsaicin nasal spray is effective in a broader group of IR than the purely selected ones described before, that subjective nasal hyper‐reactivity is a good predictor of positive outcome, and that the time interval for seeking a second treatment is likely to be shorter in MR patients than in the strictly selected IR patients.
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There is no evidence for capsaicin use in NO caused by allergic rhinitis and chronic rhinosinusitis.
“Although it is considered a therapeutic option in NAR, there is no evidence for its use in NO caused by AR and CRS [156,157].”
From Position Paper on Nasal Obstruction: Evaluation and Treatment (2018) · cites this paper as [156]
The paper reports capsaicin efficacy in idiopathic rhinitis, a form of nonallergic rhinitis (Abstract, page not provided). It says earlier trials excluded patients with chronic rhinosinusitis, but its own mixed-rhinitis group included some patients with positive allergy tests and nasal obstruction (Abstract/Table 1, page not provided). It does not establish the broader claim that no evidence exists for capsaicin use in nasal obstruction caused by allergic rhinitis or chronic rhinosinusitis. (LLM, conf=0.83)
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Research works printed but not linked: 11
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- Gevorgyan A, 2015, Capsaicin for non‐allergic rhinitis, Cochrane Database Syst Rev, 7, CD010591
- 10.1016/j.jaci.2013.08.026 · DOI
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- 10.2500/aap.2010.31.3380 · DOI
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Cited by
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Position Paper on Nasal Obstruction: Evaluation and Treatment
SEAIC Rhinoconjunctivitis Committee & SEORL Rhinology, A., Valero, A., Navarro, A., del Cuvillo, A., Alobid, I., Benito, Jr., Colás, C., de los Santos, G., Fernández Liesa, R., García-Lliberós, A., et al. (2018) · Journal of Investigational Allergology and Clinical Immunology · doi:10.18176/jiaci.0232 · Cited by 76
Metadata
- Authors
- Van Gerven, L., Steelant, B., Alpizar, Y. A., Talavera, K., & Hellings, P. W.
- Affiliations
- Clinical division of Otorhinolaryngology Head & Neck Surgery University Hospitals Leuven Leuven Belgium
- KU Leuven (BE)
- Universitair Ziekenhuis Leuven (BE)
- Corresponding author
- Hellings, P. W.
- Venue
- Allergy
- Publisher
- Wiley
- Published
- 2017-08-24
- Volume
- 73
- Issue
- 1
- Pages
- 248-250
- ISSN
- 0105-4538 (ISSN-L)
- 1398-9995
- OpenAlex
- W2519424850
- Cited by
- 18
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 1 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 2
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- Locations
- Allergy (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Lirias (submittedVersion)
- Funders
- Agentschap voor Innovatie door Wetenschap en Technologie
- Fonds Wetenschappelijk Onderzoek (G.0565.07, G.0686.09)
- KU Leuven (GOA 2009/07, EF/95/010, PFV/10/006)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Otorhinolaryngology › Sinusitis and nasal conditions
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Keywords
- capsaicin, nasal spray, vasomotor rhinitis, intranasal corticosteroids, nasal hyperreactivity, treatment efficacy, second-line therapy
- MeSH terms
- Administration, Intranasal, Adult, Aged, Aged, 80 and over, Capsaicin, Female, Humans, Male, Middle Aged, Nasal Mucosa, Rhinitis, Steroids, Treatment Outcome, Young Adult
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