Increased attention-deficit/hyperactivity symptoms in atopic dermatitis are associated with history of antihistamine use
Abstract
Background Epidemiologic evidence indicates a relevant association between atopic dermatitis (AD) and attention-deficit/hyperactivity disorder (ADHD). Underlying mechanisms and ways to best identify subgroups of AD patients at risk for ADHD are poorly understood. Aims of the study To compare sociodemographic, clinical and psychosocial characteristics of children with AD, ADHD, comorbid AD/ADHD and age-matched healthy controls and to investigate aspects of AD related to ADHD symptoms. Methods Applying a factorial design, we investigated 4 groups of children aged 6-12 years: AD-only (ie, without ADHD), ADHD-only (ie, without AD), AD + ADHD and healthy controls (HC; ie, no AD/no ADHD). Using validated instruments, ADHD symptoms and other behavioural problems, quality of life, parenting stress and sleeping problems were compared between groups. In children with AD-only, clinical signs (objective SCORAD), symptoms (POEM, VAS pruritus, VAS sleeping problems) and previous treatment of AD were assessed to investigate disease patterns related to ADHD symptoms. Results Compared to HC (n = 47), children with AD-only (n = 42), ADHD-only (n = 34) and comorbid AD + ADHD (n = 31) had significantly increased behavioural problems and decreased quality of life. Children with AD-only had significantly higher levels of ADHD symptoms than HC. In children with AD-only, previous use of antihistamines was significantly associated with increased ADHD symptoms (OR 1.88; 95% CI 1.04-3.39). Current clin…
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Research also associates ADHD with the use of antihistamines (OR = 1.88; 95% CI 1.04‒3.39).
“Research also associates ADHD with the use of antihistamines (OR = 1.88; 95% CI 1.04‒3.39), although studies on cetirizine did not find any significant differences compared to placebo in the children’s behavioral and developmental assessments.116, 117”
From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [116]
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“When interpreting our findings, it also has to be considered that the objective severity of AD in infancy could not be assessed due to the lack of a validated instrument.(44) Thus, an alternative interpretation of the study results is that early antihistamine exposure reflects the severity of AD symptoms in infancy an…”
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- Authors
- Schmitt, J., Buske‐Kirschbaum, A., Tesch, F., Trikojat, K., Stephan, V., Abraham, S., Bauer, A., Nemat, K., Plessow, F., & Roessner, V.
- Affiliations
- University Hospital Carl Gustav Carus (DE)
- Department of Biopsychology TU Dresden Dresden Germany
- Zentrum für Evidenzbasierte Gesundheitsversorgung (DE)
- Technische Universität Dresden (DE)
- Harvard University (US)
- Corresponding author
- Schmitt, J.
- ORCID
- Venue
- Allergy
- Publisher
- Wiley
- Published
- 2017-11-20
- Volume
- 73
- Issue
- 3
- Pages
- 615-626
- ISSN
- 0105-4538 (ISSN-L)
- 1398-9995
- OpenAlex
- W2762759951
- Cited by
- 66
- References
- 7
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 10 · 2021: 7 · 2020: 10 · 2019: 12 · 2018: 6
- FWCI
- 8.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Allergy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SCHM 2838/2‐1, BU 747/8‐1)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- atopic dermatitis, attention deficit hyperactivity disorder, ADHD comorbidity, antihistamine use, childhood, behavioral problems, quality of life, parental stress, sleep disorders, pruritus, risk factors
- MeSH terms
- Problem Behavior, Attention Deficit Disorder with Hyperactivity, Child, Dermatitis, Atopic, Female, Histamine Antagonists, Humans, Male
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