Association between total globozoospermia and sperm chromatin defects
Abstract
Globozoospermia is a severe sperm morphological anomaly leading to primary infertility and low fertilisation following intracytoplasmic sperm injection (ICSI). This phenotype is observed in less than 0.1% of infertile men and is determined by small, round-headed spermatozoa with absence of an acrosomal cap, acrosome protease and also cytoskeletal proteins. Failure of oocyte activation is considered as the main cause of fertilisation failure in these individuals post-ICSI. Therefore, artificial oocyte activation (AOA) along with ICSI is commonly implemented. However, based on previous report, fertilisation rate remains low despite implementation of ICSI-AOA. Therefore, other mechanisms like sperm chromatin packaging and DNA fragmentation may account for low fertilisation and development post-ICSI-AOA. Therefore, this study aims to assess and compare the degree of sperm protamine deficiency and DNA fragmentation in large population of infertile men with total globozoospermia (30 globozoospermic men presenting with 100% round-headed spermatozoa) with 22 fertile individuals using chromomycin A3 and TUNEL assay respectively. Results clearly show that mean of sperm concentration and percentage of sperm motility were significantly lower, while percentage of sperm abnormal morphology, protamine-deficient and DNA-fragmented spermatozoa were significantly higher in infertile men with globozoospermia compared to fertile men. Therefore, increased sperm DNA damage in globozoospermia is li…
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Globozoospermia is associated with aneuploid spermatozoa and sperm DNA fragmentation.
“Like macrozoospermia, it is also associated with aneuploid spermatozoa and SDF (44).”
From Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review (2024) · cites this paper as [44]
Cites
Zhao, J., Zhang, Q., Wang, Y., & Li, Y. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.06.033 · Cited by 361 · see citing works
Rybouchkin, A. V., Van der Straeten, F., Quatacker, J., De Sutter, P., & Dhont, M. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00378-6 · Cited by 169 · see citing works
Genetic aspects of monomorphic teratozoospermia: a review
De Braekeleer, M., Nguyen, M. H., Morel, F., & Perrin, A. (2015) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-015-0433-2 · Cited by 135 · see citing works
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Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review
Atmoko, W., Savira, M., Shah, R., Chung, E., & Agarwal, A. (2024) · Translational Andrology and Urology · doi:10.21037/tau-23-397 · Cited by 23 · see citing works
“Other areas for future research include studies on SDF in patients with isolated teratozoospermia, and studies on the clinical efficacy and risk-benefit analysis of ART in the context of isolated teratozoospermia.”
Influential
- Authors
- Eskandari, N., Tavalaee, M., Zohrabi, D., & Nasr-Esfahani, M. H.
- Affiliations
- Royan Institute (IR)
- NourDanesh Institute of Higher Education (IR)
- Corresponding author
- Tavalaee, M.
- Nasr-Esfahani, M. H.
- Venue
- Andrologia
- Publisher
- Wiley
- Published
- 2017-06-29
- Volume
- 50
- Issue
- 2
- Pages
- e12843
- ISSN
- 0303-4569 (ISSN-L)
- OpenAlex
- W2732474695
- Cited by
- 26
- References
- 3
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 3
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Andrologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Royan Institute
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- sperm DNA fragmentation, protamine deficiency, male infertility, intracytoplasmic sperm injection, artificial oocyte activation, sperm motility, sperm morphology, antioxidant therapy
- MeSH terms
- Teratozoospermia, Acrosome, Adult, Antioxidants, Chromatin, Humans, Male, Protamines, Sperm Motility, In Situ Nick-End Labeling, Sperm Injections, Intracytoplasmic, DNA Fragmentation
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