The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.
The impact of drugs on male fertility: a review
Abstract
Summary: Beside cytotoxic drugs, other drugs can impact men's fertility through various mechanisms. Via the modification of the hypothalamic–pituitary–gonadal axis hormones or by non‐hormonal mechanisms, drugs may directly and indirectly induce sexual dysfunction and spermatogenesis impairment and alteration of epididymal maturation. This systematic literature review summarizes existing data about the negative impact and associations of pharmacological treatments on male fertility (excluding cytotoxic drugs), with a view to making these data more readily available for medical staff. In most cases, these effects on spermatogenesis/sperm maturation/sexual function are reversible after the discontinuation of the drug. When a reprotoxic treatment cannot be stopped and/or when the impact on semen parameters/sperm DNA is potentially irreversible (Sulfasalazine Azathioprine, Mycophenolate mofetil and Methotrexate), the cryopreservation of spermatozoa before treatment must be proposed. Deleterious impacts on fertility of drugs with very good or good level of evidence (Testosterone, Sulfasalazine, Anabolic steroids, Cyproterone acetate, Opioids, Tramadol, GhRH analogues and Sartan) are developed.
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Cites
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Cited by
Fertility and infertility: Definition and epidemiology
Vander Borght, M., & Wyns, C. (2018) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2018.03.012 · Cited by 2,278
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Metadata
- Authors
- Semet, M., Paci, M., Saïas‐Magnan, J., Metzler‐Guillemain, C., Boissier, R., Lejeune, H., & Perrin, J.
- Venue
- Andrology
- Publisher
- Wiley
- Published
- 2017-06-16
- Volume
- 5
- Issue
- 4
- Pages
- 640-663
- ISSN
- 2047-2919 (ISSN-L)
- 2047-2927
- OpenAlex
- W2626574391
- Cited by
- 344
- References
- 151
- FWCI
- 21.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Semet, M., Paci, M., Saïas‐Magnan, J., Metzler‐Guillemain, C., Boissier, R., Lejeune, H., & Perrin, J. (2017). The impact of drugs on male fertility: a review. Andrology. https://doi.org/10.1111/andr.12366
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
