The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Neutrophil gelatinase‐associated lipocalin: pathophysiology and clinical applications
Open accessAbstract
Neutrophil gelatinase‐associated lipocalin (NGAL), a 25 kDa protein produced by injured nephron epithelia, is one of the most promising new markers of renal epithelial injury. In contrast to serum creatinine and urinary output, which are the measures of kidney function, NGAL is specifically induced in the damaged nephron and then released into blood and urine, where it can be readily measured. Careful proof‐of‐concept studies using defined animal models have uncovered the sources and trafficking of NGAL in acute kidney injury (AKI) and have addressed the contributions of renal and non‐renal sources. Clinical studies indicate that NGAL, unlike creatinine, is a marker responsive to tissue stress and nephron injury, but less so to adaptive hemodynamic responses. In certain clinical settings, NGAL is an earlier marker compared with serum creatinine. In addition, clinical studies have shown that NGAL is a powerful predictor of poor clinical outcomes, which can be used to risk stratify patients when combined with serum creatinine. NGAL has important limitations, including its responsiveness in systemic inflammation, which is partially uncoupled from its response to kidney injury and which needs to be considered when interpreting NGAL results clinically. This review covers the biology and pathophysiology of NGAL and summarizes the results of the growing body of clinical studies that have addressed the utility of NGAL in the early diagnosis of AKI, in the distinction of intrinsic AKI and in the prognostic assessment of broad patient populations.
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Cites
Mishra, J., Ma, Q., Prada, A., Mitsnefes, M., Zahedi, K., Yang, J., Barasch, J., & Devarajan, P. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000088027.54400.c6 · Cited by 1,749
Self-citationGoetz, D. H., Holmes, M. A., Borregaard, N., Bluhm, M. E., Raymond, K. N., & Strong, R. K. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00708-6 · Cited by 1,355
Mori, K., Lee, H. T., Rapoport, D., Drexler, I. R., Foster, K., Yang, J., Schmidt-Ott, K. M., Chen, X., Li, J. Y., Weiss, S., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23056 · Cited by 954
Self-citationThe lipocalin protein family: structural and sequence overview
Flower, D. R., North, A. C. T., & Sansom, C. E. (2000) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(00)00148-5 · Cited by 868
Dual Action of Neutrophil Gelatinase–Associated Lipocalin
Schmidt-Ott, K. M., Mori, K., Li, J. Y., Kalandadze, A., Cohen, D. J., Devarajan, P., & Barasch, J. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006080882 · Cited by 772
Self-citationAn Iron Delivery Pathway Mediated by a Lipocalin
Yang, J., Goetz, D., Li, J.-Y., Wang, W., Mori, K., Setlik, D., Du, T., Erdjument-Bromage, H., Tempst, P., Strong, R., et al. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00710-4 · Cited by 651
Self-citationDent, C. L., Ma, Q., Dastrala, S., Bennett, M., Mitsnefes, M. M., Barasch, J., & Devarajan, P. (2007) · Critical Care · doi:10.1186/cc6192 · Cited by 483
Self-citationHuman neutrophil gelatinase-associated lipocalin and homologous proteins in rat and mouse
Kjeldsen, L., Cowland, J. B., & Borregaard, N. (2000) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(00)00152-7 · Cited by 368
Iron traffics in circulation bound to a siderocalin (Ngal)–catechol complex
Bao, G., Clifton, M., Hoette, T. M., Mori, K., Deng, S.-X., Qiu, A., Viltard, M., Williams, D., Paragas, N., Leete, T., et al. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.402 · Cited by 307 · cited 1×
“Neutrophil gelatinase-associated lipocalin binds bacterial siderophores or endogenous compounds in mammals, including catechol, with high affinity (Cai et al. 2010; Bao et al. 2010).”
BackgroundSelf-citationUrinary neutrophil gelatinase-associated lipocalcin in D+HUS: a novel marker of renal injury
Investigators of the HUS-SYNSORB Pk Multicenter Clinical Trial, Trachtman, H., Christen, E., Cnaan, A., Patrick, J., Mai, V., Mishra, J., Jain, A., Bullington, N., & Devarajan, P. (2006) · Pediatric Nephrology · doi:10.1007/s00467-006-0146-y · Cited by 204
Cited by
Contrast Medium-Induced Acute Kidney Injury
Sadat, U., Usman, A., Boyle, J. R., Hayes, P. D., & Solomon, R. J. (2015) · Cardiorenal Medicine · doi:10.1159/000430770 · Cited by 1,285
Biomarkers in acute kidney injury – pathophysiological basis and clinical performance
Schrezenmeier, E. V., Barasch, J., Budde, K., Westhoff, T., & Schmidt‐Ott, K. M. (2017) · Acta Physiologica · doi:10.1111/apha.12764 · Cited by 401
Self-citationUnderstanding and preventing contrast-induced acute kidney injury
Fähling, M., Seeliger, E., Patzak, A., & Persson, P. B. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.196 · Cited by 323
Diverse functional roles of lipocalin-2 in the central nervous system
Jha, M. K., Lee, S., Park, D. H., Kook, H., Park, K.-G., Lee, I.-K., & Suk, K. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.006 · Cited by 195
Metadata
- Authors
- Singer, E., Markó, L., Paragas, N., Barasch, J., Dragun, D., Müller, D. N., Budde, K., & Schmidt‐Ott, K. M.
- Venue
- Acta Physiologica
- Publisher
- Wiley
- Published
- 2013-02-04
- Volume
- 207
- Issue
- 4
- Pages
- 663-672
- ISSN
- 1748-1708 (ISSN-L)
- 1748-1716
- OpenAlex
- W2120930364
- Cited by
- 282
- References
- 10
- FWCI
- 16.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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