The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Skin temperature: its role in thermoregulation
Open accessAbstract
This review analyses whether skin temperature represents ambient temperature and serves as a feedforward signal for the thermoregulation system, or whether it is one of the body's temperatures and provides feedback. The body is covered mostly by hairy (non‐glabrous) skin, which is typically insulated from the environment (with clothes in humans and with fur in non‐human mammals). Thermal signals from hairy skin represent a temperature of the insulated superficial layer of the body and provide feedback to the thermoregulation system. It is explained that this feedback is auxiliary, both negative and positive, and that it reduces the system's response time and load error. Non‐hairy (glabrous) skin covers specialized heat‐exchange organs (e.g. the hand), which are also used to explore the environment. In thermoregulation, these organs are primarily effectors. Their main thermosensory‐related role is to assess local temperatures of objects explored; these local temperatures are feedforward signals for various behaviours. Non‐hairy skin also contributes to the feedback for thermoregulation, but this contribution is limited. Autonomic (physiological) thermoregulation does not use feedforward signals. Thermoregulatory behaviours use both feedback and feedforward signals. Implications of these principles to thermopharmacology, a new approach to achieving biological effects by blocking temperature signals with drugs, are discussed.
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“Indeed, an increase in hair follicle amount will augment the organism’s capacity to thermally insulate and increase the thermal stability of the skin [32].”
From Human thermal perception and time of day: A review (2021) · cites this paper as [32]
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“Thus, the regulated variable in the thermoregulation system is an integrative temperature signal, which incorporates spatially distributed core body and skin temperatures [32].”
From Human thermal perception and time of day: A review (2021) · cites this paper as [32]
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Cites
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
Story, G. M., Peier, A. M., Reeve, A. J., Eid, S. R., Mosbacher, J., Hricik, T., Earley, T. J., Hergarden, A. C., Andersson, D. A., Hwang, S. W., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00158-2 · Cited by 2,494
The menthol receptor TRPM8 is the principal detector of environmental cold
Bautista, D. M., Siemens, J., Glazer, J. M., Tsuruda, P. R., Basbaum, A. I., Stucky, C. L., Jordt, S. E., & Julius, D. J. (2007) · Nature · doi:10.1038/nature05910 · Cited by 1,392
Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system
Romanovsky, A. A. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00668.2006 · Cited by 786
Self-citationCentral circuitries for body temperature regulation and fever
Nakamura, K. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00109.2011 · Cited by 543
Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans
Gavva, N. R., Treanor, J. J. S., Garami, A., Fang, L., Surapaneni, S., Akrami, A., Alvarez, F., Bak, A., Darling, M., Gore, A., et al. (2008) · Pain · doi:10.1016/j.pain.2008.01.024 · Cited by 527
Self-citationA thermosensory pathway that controls body temperature
Nakamura, K., & Morrison, S. F. (2007) · Nature Neuroscience · doi:10.1038/nn2027 · Cited by 503
Transient receptor potential ion channels as participants in thermosensation and thermoregulation
Caterina, M. J. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00446.2006 · Cited by 442
Temperature sensitivity of the body surface over the life span
CHOO, J. C. S. K. K. (1998) · Somatosensory & Motor Research · doi:10.1080/08990229870925 · Cited by 361
The transient receptor potential channel TRPA1: from gene to pathophysiology
Nilius, B., Appendino, G., & Owsianik, G. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-012-1158-z · Cited by 352
Romanovsky, A. A., Ivanov, A. I., & Shimansky, Y. P. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01173.2001 · Cited by 351
Self-citationLessons from peppers and peppermint: the molecular logic of thermosensation
Jordt, S., McKemy, D. D., & Julius, D. J. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00101-6 · Cited by 343
Changes in cutaneous and body temperature during and after conditioned fear to context in the rat
Vianna, D. M. L., & Carrive, P. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04073.x · Cited by 327
TRPA1 Contributes to Cold Hypersensitivity
del Camino, D., Murphy, S. A., Heiry, M., Barrett, L. B., Earley, T. J., Cook, C. A., Petrus, M. J., Zhao, M. A., D’Amours, M., Deering, N., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2580-10.2010 · Cited by 288
Chen, J., Joshi, S. K., DiDomenico, S., Perner, R. J., Mikusa, J. P., Gauvin, D. M., Segreti, J. A., Han, P., Zhang, X.-F., Niforatos, W., et al. (2011) · Pain · doi:10.1016/j.pain.2011.01.049 · Cited by 281
A thermosensory pathway mediating heat-defense responses
Nakamura, K., & Morrison, S. F. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913358107 · Cited by 267
Almeida, M. C., Hew‐Butler, T., Soriano, R. N., Rao, S. P., Wang, W., Wang, L., Tamayo, N. A., de Oliveira, D. L., Nucci, T. B., Aryal, P., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5606-11.2012 · Cited by 254
Self-citationThe transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not
Romanovsky, A. A., Almeida, M. C., Garami, A., Steiner, A. A., Norman, M. H., Morrison, S. F., Nakamura, K., Burmeister, J. J., & Nucci, T. B. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001263 · Cited by 253
Self-citationNakamura, K., & Morrison, S. F. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00427.2006 · Cited by 242
Steiner, A. A., Turek, V. F., Almeida, M. C., Burmeister, J. J., de Oliveira, D. L., Roberts, J., Bannon, A. W., Norman, M. H., Louis, J., Treanor, J. J. S., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1483-07.2007 · Cited by 228
Self-citationTHE THERMOSENSITIVITY OF THE HYPOTHALAMUS AND THERMOREGULATION IN MAMMALS
BLIGH, J. (1966) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.1966.tb01496.x · Cited by 222
The Cellular Code for Mammalian Thermosensation
Pogorzala, L., Mishra, S. K., & Hoon, M. A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5788-12.2013 · Cited by 220
Differential thermal sensitivity in the human skin
NADEL, E. R., Mitchell, J. W., & Stolwijk, J. A. J. (1973) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00592198 · Cited by 205
Pharmacological Blockade of TRPM8 Ion Channels Alters Cold and Cold Pain Responses in Mice
Knowlton, W., Daniels, R. L., Palkar, R., McCoy, D. D., & McKemy, D. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025894 · Cited by 203
From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs
Bandell, M., Macpherson, L. J., & Patapoutian, A. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.07.014 · Cited by 199
Kern und Schale im W�rmehaushalt des Menschen
Aschoff, J., & Wever, R. A. (1958) · Die Naturwissenschaften · doi:10.1007/bf00635546 · Cited by 167
Contributions of Different Modes of TRPV1 Activation to TRPV1 Antagonist-Induced Hyperthermia
Garami, A., Shimansky, Y. P., Pákai, E., de Oliveira, D. L., Gavva, N. R., & Romanovsky, A. A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5150-09.2010 · Cited by 162
Self-citationControl of skin blood flow in the neutral zone of human body temperature regulation
Savage, M. V., & Brengelmann, G. L. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.80.4.1249 · Cited by 157
Cold‐seeking behavior as a thermoregulatory strategy in systemic inflammation
Almeida, M. C., Steiner, A. A., Branco, L. G. S., & Romanovsky, A. A. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04854.x · Cited by 153
Self-citationFunctional architecture of behavioural thermoregulation
Flouris, A. D. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1602-8 · Cited by 131
Hensel, H. (1974) · Annual Review of Physiology · doi:10.1146/annurev.ph.36.030174.001313 · Cited by 128
Relative importance of different surface regions for thermal comfort in humans
Nakamura, M., Yoda, T., Crawshaw, L. I., Kasuga, M., Uchida, Y., Tokizawa, K., Nagashima, K., & Kanosue, K. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2406-9 · Cited by 105
System properties, feedback control and effector coordination of human temperature regulation
Werner, J. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1216-1 · Cited by 99
Thermal afferents in the control of body temperature
Jessen, C. (1985) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(85)90085-3 · Cited by 97
TRP channels as therapeutic targets in airway disorders: a patent review
Preti, D., SZALLASI, A., & Patacchini, R. (2012) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2012.696099 · Cited by 84
Loftus, R. (1968) · Journal of Comparative Physiology A · doi:10.1007/bf00365971 · Cited by 83
Kanosue, K., Crawshaw, L. I., Nagashima, K., & Yoda, T. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1256-6 · Cited by 82
Human medullary responses to cooling and rewarming the skin: A functional MRI study
McAllen, R. M., Farrell, M. J., Johnson, J. M., Trevaks, D., Cole, L. J., McKinley, M. J., Jackson, G. D., Denton, D. A., & Egan, G. F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509862103 · Cited by 78
Ionic Basis of Cold Receptors Acting as Thermostats
Okazawa, M., Takao, K., Hori, A., Shiraki, T., Matsumura, K., & Kobayashi, S. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-10-03994.2002 · Cited by 77
The concept of regulation for human body temperature
Werner, J. (1980) · Journal of Thermal Biology · doi:10.1016/0306-4565(80)90003-0 · Cited by 77
Marks, A. R., Vianna, D. M. L., & Carrive, P. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90723.2008 · Cited by 76
Székely, M., & Szelényi, Z. (1979) · PubMed · Cited by 76
Jessen, C. (1981) · The Journal of Physiology · doi:10.1113/jphysiol.1981.sp013570 · Cited by 72
Tanaka, M., Owens, N. C., Nagashima, K., Kanosue, K., & McAllen, R. M. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.102400 · Cited by 72
Cutaneous Infrared Thermometry for Detecting Febrile Patients
Hausfater, P., Zhao, Y., Defrenne, S., Bonnet, P., & Riou, B. (2008) · Emerging infectious diseases · doi:10.3201/eid1408.080059 · Cited by 70
Evidence that peripheral rather than intracranial thermal signals induce thermoregulation
Bratincsák, A., & Palkovits, M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.028 · Cited by 61
Influence of isometric exercise on blood flow and sweating in glabrous and nonglabrous human skin
Saad, A. R., Stephens, D. P., Bennett, L. A. T., Charkoudian, N., Kosiba, W. A., & Johnson, J. M. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.6.2487 · Cited by 61
Role of skin temperature in the control of sweating
McCaffrey, T. V., Wurster, R. D., Jacobs, H. K., Euler, D. E., & Geis, G. (1979) · Journal of Applied Physiology · doi:10.1152/jappl.1979.47.3.591 · Cited by 59
Roberts, W. W. (1988) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1988.tb38620.x · Cited by 54
A comparison between total body thermosensitivity and local thermosensitivity in mammals and birds
Mercer, J. B., & Simon, E. (1984) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00581552 · Cited by 48
Chen, J., & Kym, P. R. (2009) · The Journal of General Physiology · doi:10.1085/jgp.200910246 · Cited by 47
Interoception and autonomic nervous system reflexes thermoregulation
Fealey, R. D. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53491-0.00007-9 · Cited by 44
Sakurada, S., Shido, O., FUJIKAKE, K., & Nagasaka, T. (1993) · The Japanese Journal of Physiology · doi:10.2170/jjphysiol.43.659 · Cited by 42
Kobayashi, S., Hori, A., Matsumura, K., & Hosokawa, H. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00655.2005 · Cited by 42
Independent vasomotor control of rat tail and proximal hairy skin
Tanaka, M., Ootsuka, Y., McKinley, M. J., & McAllen, R. M. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.131292 · Cited by 40
Kondo, N., Yanagimoto, S., Nishiyasu, T., & Crandall, C. G. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00810.2002 · Cited by 38
Cabanac, M. (1995) · Cited by 37
Neither Arm nor Face Warming Reduces the Shivering Threshold in Unanesthetized Humans
Doufas, A. G., Wadhwa, A. N., Lin, C.-M., Shah, Y. M., Hanni, K. B., & Sessler, D. I. (2003) · Stroke · doi:10.1161/01.str.0000077014.47422.db · Cited by 29
Control of local heat gain by vasomotor response of the hand
Nagasaka, T., Cabanac, M., Hirata, K., & Nunomura, T. (1987) · Journal of Applied Physiology · doi:10.1152/jappl.1987.63.4.1335 · Cited by 24
Experimental Determination of Heat Flow Parameters during Induction of General Anesthesia
Sessler, D. I., & Sessler, A. M. (1998) · Anesthesiology · doi:10.1097/00000542-199809000-00015 · Cited by 23
Lecture Notes - Human Physiology
Petersen, O. H. (2006) · Blackwell eBooks · Cited by 21
A difference of 5°C between ear and rectal temperatures in a febrile patient
Romanovsky, A. A., Quint, P. A., Benikova, Y., & Kiesow, L. A. (1997) · The American Journal of Emergency Medicine · doi:10.1016/s0735-6757(97)90133-9 · Cited by 21
Self-citationFever Determination in Young Infants
Katz‐Sidlow, R. J., Rowberry, J. P., & Ho, M. (2009) · Pediatric Emergency Care · doi:10.1097/pec.0b013e31819dac6 · Cited by 16
Huckaba, C. E., Downey, J., & Darling, R. C. (1971) · International Journal of Biometeorology · doi:10.1007/bf01803888 · Cited by 14
The nervous system: its function and its interaction with the world
(1993) · Choice Reviews Online · doi:10.5860/choice.31-0294 · Cited by 13
Antriebe und effektorische Ma�nahmen der Thermoregulation bei Ruhe und w�hrend k�rperlicher Arbeit
Kitzing, J., Behling, K., Bleichert, A., Scarperi, M., & Scarperi, S. (1972) · European Journal of Applied Physiology · doi:10.1007/bf00704174 · Cited by 11
Kitzing, J., Behling, K., Bleichert, A., Scarperi, M., & Scarperi, S. (1972) · PubMed · Cited by 10
[The temperature gradient values in the skin and their significance for thermoregulation].
Slepchuk, N. A., & Kp, I. (1992) · PubMed · Cited by 3
Flagged first, then by citations
Research works printed but not linked: 1
- Kitzing J., 1972, Antriebe und effektorische Massnahmen der Thermoregulation bei Ruhe und waehrend koerperlicher Arbeit, Int Z Angew Physiol, 30, 119
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Metadata
- Authors
- Romanovsky, A. A.
- Affiliations
- St. Joseph's Hospital and Medical Center (US)
- Corresponding author
- Romanovsky, A. A.
- ORCID
- Romanovsky, A. A.
- Venue
- Acta Physiologica
- Publisher
- Wiley
- Published
- 2014-02-06
- Volume
- 210
- Issue
- 3
- Pages
- 498-507
- ISSN
- 1748-1708 (ISSN-L)
- 1748-1716
- PMC
- PMC4159593
- OpenAlex
- W2164803343
- Cited by
- 518
- References
- 68
- Citations by year
- 2026: 51 · 2025: 62 · 2024: 57 · 2023: 45 · 2022: 49 · 2021: 57 · 2020: 37 · 2019: 42 · 2018: 44 · 2017: 25 · 2016: 23 · 2015: 19 · 2014: 7
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Acta Physiologica (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Amgen
- Abbott Laboratories
- AbbVie
- National Institutes of Health (R01NS41233l)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Effects of Environmental Stressors on Livestock
- Keywords
- skin temperature, thermoregulation, feedforward control, feedback control, hairy skin, glabrous skin, thermoreceptors, thermosensation, behavioral thermoregulation, autonomic thermoregulation
- MeSH terms
- Animals, Body Temperature Regulation, Humans, Skin Temperature
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