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Protective effects of coffee consumption following liver transplantation for hepatocellular carcinoma in cirrhosis

Wiltberger, Georg, Wu, Yan, Lange, Undine, Hau, Hans‐Michael, Tapper, Elliot, Krenzien, Felix, Atanasov, Georgi, Benzing, Christian, Feldbrügge, Linda, Csizmadia, Eva, Broschewitz, Johannes, Bartels, Michael, Seehofer, Daniel, Jonas, Sven, Berg, Thomas, Hessel, Phillip, Ascherl, Rudi, Neumann, Ulf P., Pratschke, Johann, Robson, Simon C., Schmelzle, Moritz·2019·Alimentary Pharmacology & Therapeutics
DOI 10.1111/apt.15089
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Abstract

Summary: Background: Increasing evidence suggests that coffee consumption might protect against hepatocellular carcinoma (HCC) and liver cirrhosis‐associated death risk. Caffeine is a natural antagonist to extracellular adenosine and exhibits experimental tumoricidal activity. Aim: To evaluate if coffee consumption has beneficial effects on HCC recurrence after orthotopic liver transplantation (OLT). Methods: Coffee consumption of patients before and after OLT for HCC was assessed and correlated with HCC recurrence. HepG2 cells were analysed for proliferation and metastasis potential after treatment with adenosine, in the presence or absence of adenosine receptor antagonists. Expression of adenosine receptors was determined, and known adenosine‐mediated cancer pathways inclusive of MAPK and NF‐kappa B were tested. Results: Ninety patients underwent OLT for HCC. Sixteen (17.8%) patients experienced HCC recurrence after median time of 11.5 months (range 1‐40.5). For overall survival postoperative coffee intake emerged as major factor of hazard reduction in a multivariate analysis (HR = 0.2936, 95% CI = 0.12‐0.71, P = 0.006). Those with such postoperative coffee intake (≥3 cups per day) had a longer overall survival than those who consumed less or no coffee: M = 11.0 years, SD = 0.52 years vs. M = 7.48 years, SD = 0.76 years = 4.7, P = 0.029). Conclusions: Coffee consumption is associated with a decreased risk of HCC recurrence and provides for increased survival following OLT. We suggest that these results might be, at least in part, associated with the antagonist activity of caffeine on adenosine‐A2AR mediated growth‐promoting effects on HCC cells.

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Metadata

Authors
Wiltberger, G., Wu, Y., Lange, U., Hau, H., Tapper, E., Krenzien, F., Atanasov, G., Benzing, C., Feldbrügge, L., Csizmadia, E., Broschewitz, J., Bartels, M., Seehofer, D., Jonas, S., Berg, T., Hessel, P., Ascherl, R., Neumann, U. P., Pratschke, J., Robson, S. C., & Schmelzle, M.
Affiliations
  • Department of General, Visceral, and Transplantation Surgery University Hospital of RWTH Aachen Aachen Germany
  • Liver Center and The Transplant Institute, Division of Gastroenterology, Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School Boston Massachusetts
  • Department of Visceral, Transplant, Thoracic and Vascular Surgery University Hospital Leipzig Leipzig Germany
  • Departmentof Surgery Charité – Universitätsmedizin Berlin Berlin Germany
  • Department of General‐ and Visceral surgery Helios Clinic Leipzig Leipzig Germany
  • Department of Hepato‐, Pancreato‐ and Biliary Surgery 310Klinik Nürnberg Nuremberg Germany
  • Section of Hepatology, Department of Internal Medicine, Neurology, Dermatology University Hospital Leipzig Leipzig Germany
  • Center for Population and Development Studies Harvard University Cambridge Massachusetts
  • Hospital for Children and Adolescents University Hospital Leipzig Leipzig Germany
ORCID
Wiltberger, Georg
Venue
Alimentary Pharmacology & Therapeutics
Publisher
Wiley
Published
2019-02-27
Volume
49
Issue
6
Pages
779-788
ISSN
  • 0269-2813
  • 1365-2036
DOI
10.1111/apt.15089
Cited by
22
References
0
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
Deutsche Forschungsgemeinschaft (SCHM2661, 3-1)

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CoChat. (2026). Citation check: Protective effects of coffee consumption following liver transplantation for hepatocellular carcinoma in cirrhosis. https://app.cochat.ai/papers/10.1111/apt.15089
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Wiltberger, G., Wu, Y., Lange, U., Hau, H., Tapper, E., Krenzien, F., Atanasov, G., Benzing, C., Feldbrügge, L., Csizmadia, E., Broschewitz, J., Bartels, M., Seehofer, D., Jonas, S., Berg, T., Hessel, P., Ascherl, R., Neumann, U. P., Pratschke, J., . . . Schmelzle, M. (2019). Protective effects of coffee consumption following liver transplantation for hepatocellular carcinoma in cirrhosis. Alimentary Pharmacology & Therapeutics. https://doi.org/10.1111/apt.15089

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.