The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
CYP2C19 and CYP2D6 genotypes in Pacific peoples
Open accessAbstract
The study of pharmacogenetic variants in populations which reside in Oceania has been focused mainly on CYP2C19 and CYP2D6. Statements about the high prevalence of CYP2C19 no function genotype in ‘Pacific Islanders’ can be found in the literature. This review article summarizes the published information about these pharmacogenes in this geographical region and highlights the differences observed between Melanesian and Polynesian populations. It is not appropriate to combine the prevalence data of pharmacogenetic variants, particularly CYP2C19, across this region. Indeed, apocryphal assumptions about CYP2C19 no function alleles and possible effect on the therapeutic activity of clopidogrel are unhelpful and reiterate the importance of assessing the individual patient rather than relying on inappropriate ethnicity‐based assumptions for drug dosing decisions.
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“For instance, studies found that clopidogrel was less effective in Pacific Islanders [26]”
From Hasty generalizations and generics in medical research: A systematic review (2024) · cites this paper as [26]
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Demographic History of Oceania Inferred from Genome-wide Data
Wollstein, A., Lao, O., Becker, C., Brauer, S., Trent, R. J., Nürnberg, P., Stoneking, M., & Kayser, M. (2010) · Current Biology · doi:10.1016/j.cub.2010.10.040 · Cited by 218
Zabalza, M., Subirana, I., Sala, J., Lluís-Ganella, C., Lucas, G., Tomás, M., Masià, R., Marrugat, J., Brugada, R., & Elosúa, R. (2011) · Heart · doi:10.1136/hrt.2011.227652 · Cited by 177
Fricke-Galindo, I., Céspedes-Garro, C., Rodrigues‐Soares, F., Naranjo, M. E. G., Delgado, A., de Andrés, F., López, M., Peñas‐Lledó, E., & LLerena, A. (2015) · The Pharmacogenomics Journal · doi:10.1038/tpj.2015.70 · Cited by 174
The impact of whole-genome sequencing on the reconstruction of human population history
Veeramah, K. R., & Hammer, M. F. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3625 · Cited by 151
LLerena, A., Naranjo, M. E. G., Rodrigues‐Soares, F., Peñas‐Lledó, E., Fariñas, H., & Tarazona‐Santos, E. (2014) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2014.964204 · Cited by 149
Prevalence of CYP2B6 alleles in malaria-endemic populations of West Africa and Papua New Guinea
Mehlotra, R. K., Ziats, M. N., Bockarie, M. J., & Zimmerman, P. A. (2006) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-005-0092-9 · Cited by 94
Precision medicine: does ethnicity information complement genotype-based prescribing decisions?
Shah, R. R., & Gaedigk, A. (2017) · Therapeutic Advances in Drug Safety · doi:10.1177/2042098617743393 · Cited by 80
Griese, E., Ilett, K. F., Kitteringham, N. R., Eichelbaum, M. F., Powell, H., Spargo, R. M., Souëf, P. N. L., Musk, A. W., & Minchin, R. F. (2001) · Pharmacogenetics · doi:10.1097/00008571-200102000-00008 · Cited by 71
The Hawaii Clopidogrel Lawsuit: The Possible Effect on Clinical Laboratory Testing
Wu, A. H. B., White, M. J., Oh, S., & Burchard, E. G. (2015) · Personalized Medicine · doi:10.2217/pme.15.4 · Cited by 68
Kancko, A., Bergqvist, Y., Taleo, G. K., Kobayakawa, T., Ishizaki, T., & rkman, A. B. (1999) · Pharmacogenetics · doi:10.1097/00008571-199906000-00006 · Cited by 64
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Rico, E. M. G., Kikuchi, A., Saito, T., Kumondai, M., Hishinuma, E., Kaneko, A., Chan, C. W., Gitaka, J., Nakayoshi, T., Oda, A., et al. (2019) · Drug Metabolism and Pharmacokinetics · doi:10.1016/j.dmpk.2019.07.003 · Cited by 14
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Hardi, H., Barinda, A. J., Mahata, L. E., & Fitrianti, Z. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1572886 · Cited by 9
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Tucci, J. D., Pumuye, P. P., Helsby, N. A., Barratt, D. T., Pokeya, P., Hombhanje, F. W., & Somogyi, A. A. (2018) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000335 · Cited by 9
Self-citationConference report: pharmacogenomics in special populations at WCP2018
Suarez‐Kurtz, G., Aklillu, E., Saito, Y., & Somogyi, A. A. (2018) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13828 · Cited by 7
Pérez‐Stable, E. J., & Rodriquez, E. J. (2019) · Ethnicity & Disease · doi:10.18865//ed.29.s1.193 · Cited by 6
Ciarleglio, A. E., & Ma, C. (2017) · PubMed Central · Cited by 4
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Leung, J. G. (2023) · Mental Health Clinician · doi:10.9740/mhc.2023.12.276 · Cited by 3
Kilpatrick, K., James, N., Smith, K., Mackay, J., Shepherd, P., Boyle, L., Thurier, Q., Ayar, Z., & Gladding, P. A. (2018) · Heart Lung and Circulation · doi:10.1016/j.hlc.2018.05.116 · Cited by 1
The history and future of pharmacogenetics in Aotearoa/New Zealand
Kennedy, M. A. (2024) · Journal of the Royal Society of New Zealand · doi:10.1080/03036758.2024.2406824 · Cited by 1
Hitchman, L. M., Kerekere, T., Miller, A. L., Goodin, E. A., Koia, C. H., Watson, H., King, F., Robertson, S. P., Wilcox, P., & Kennedy, M. A. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2026.1668409 · Cited by 1
Robertson, S. P., Halliday, B. J., Tibble, R., Koia, C. H., Haereroa, T., Goodin, E. A., Curran, B., Rye, C. E., Wihongi, H., Aika, B. T., et al. (2026) · Journal of Community Genetics · doi:10.1007/s12687-026-00914-7 · Cited by 2
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Coleman, M. D. (2020) · Wiley eBooks · doi:10.1002/9781119658016.ch7
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Metadata
- Authors
- Helsby, N. A.
- Affiliations
- University of Auckland (NZ)
- Corresponding author
- Helsby, Nuala A.
- ORCID
- Helsby, Nuala A.
- Venue
- British Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 2016-08-26
- Volume
- 82
- Issue
- 5
- Pages
- 1303-1307
- ISSN
- 0306-5251 (ISSN-L)
- 1365-2125
- PMC
- PMC5061802
- OpenAlex
- W2432817469
- Cited by
- 20
- References
- 27
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 2
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- British Journal of Clinical Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ResearchSpace (University of Auckland) (submittedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- CYP2C19, CYP2D6, pharmacogenetic variants, Pacific Islanders, Melanesian population, Polynesian populations, CYP2C19 loss-of-function alleles, clopidogrel response, ethnic differences in drug response, individualized dosing, Oceania
- MeSH terms
- Pharmacogenomic Variants, Pacific Island People, Genotype, Humans, Melanesia, Polynesia, Cytochrome P-450 CYP2D6, Cytochrome P-450 CYP2C19
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