Underrepresentation of the elderly in clinical trials, time for action

Cited by (160)

Items 101–160 of 160

1. Electrocardiographic Abnormalities in Elderly Patients Receiving Psychotropic Therapy in the Emergency Department: A Retrospective Cohort Study
   Marianna Mazza, Marcello Covino, Filippo Bambini, Enrico Romagnoli, Giuseppe Biondi‐Zoccai, Mariella Fuorlo, Fabiana Barone, Simona Racco, Benedetta Simeoni, Francesco Franceschi et al. · 2025 · Life
2. Advancing Cardiovascular Sciences in Ageing for Cardiovascular Longevity Through Transformation and Implementation
   Jie Jun Wong, Terrance Siang Jin Chua, Angela Su-Mei Koh · 2025 · Journal of Asian Pacific Society of Cardiology
3. Feasibility, acceptability, and effectiveness of an asynchronous, internet-delivered acceptance and commitment therapy for people living with cancer: A pilot randomized controlled trial using mixed methods
   Tao Zhang, Wan Feng, Yu Sun, Ying Li, Jiawei Hu, Xiayu Du, Lizu Lai, Yingzi Ke, Bryant P. H. Hui, Zhihong Ren · 2025 · Computers in Human Behavior Reports
4. Age perceptions and physical health: implications for physiology, function, and well-being
   Caroline Williams, Tracey L. Gendron, Leland Waters · 2025 · Elsevier eBooks
5. Middle-aged sandwich generation: the utilization of social capital in coping with the caring demands and threats to mental health
   Gigi Lam, Catherine So-Kum Tang, Tak Sang Chow · 2026 · Frontiers in Public Health
6. Embracing the Digital Revolution: How Artificial Intelligence is Transforming Clinical Trials in Older Participants
   Yaru Wang, Miao Miao, Qingqing Wang, Yuyin Yin, Haijuan Zhao, Shuang Zhao, Han Yang, XIN WANG · 2026 · Drugs & Aging
7. Trends and Predictors of Premature Termination of Cardiovascular Trials
   Frederick Berro Rivera, Nathan Ross B. Bantayan, John Vincent Magalong, Chieh-Mei Tsai, Nicole Ann Tesoro, Polyn Luz S Pine, Neill Steven Cainglet Cachuela, Sung Whoy Cha, Christine J. Lin, Vuyisile Tlhopane Nkomo et al. · 2026 · JACC Advances
8. Propensity-Score Matched Analysis of Short-term Outcomes of Laparoscopic Compared to Open Surgery in Octogenarian and Nonagenarian Patients With Colon Cancer
   Sameh Hany Emile, Zoe Garoufalia, Anjelli Wignakumar, Michal Perets, Steven D. Wexner · 2026 · The American Surgeon
9. Long-Term Care medicines formularies: any reasons for pharmacists’ concern?
   João Gonçalves, Giordano Avancini Solé, Afonso Miguel das Neves Cavaco · 2023 · Brazilian Journal of Pharmaceutical Sciences
10. Representation of older patients in the safety analysis of protein kinase inhibitor registration studies
    Emma van Kampen, Mark T. J. van Bussel, Thijs H. Oude Munnink, Daan Johannes Touw, K. Esther Broekman · 2023 · Journal of Geriatric Oncology
11. Drug Metabolism
    Saskia J. Rietjens, Dylan W. de Lange · 2022 · Lessons from the ICU
12. Why the preoccupation with sex?
    Angela Saini · 2022 · The Lancet
13. A Mountainscape of Varied Perspectives (Un paysage de montagne aux perspectives variées)
    Haley Rebecca May Toll, Ashley Toll · 2021 · Canadian Journal of Art Therapy
14. Participant Flow Diagrams for Health Equity in AI Research
    Jacob Ellen, João Carlos Ramos Gonçalves de Matos, Martin Viola, Jack Gallifant, Justin Michael Quion, Leo Anthony Celi, Nebal S. Abu Hussein · 2023 · medRxiv
15. COVID-19 vaccines in elderly subjects: Considerations on efficacy and safety
    Bongiovanni Marco · 2021 · Archives of Clinical Gastroenterology
16. Risk Factors and Characteristics of Adverse Reactions Associated with the Use of Beta-Lactam Antibiotics in Older Patients
    Е. А. Сокова, V. V. Arkhipov, О. А. Демидова, И. А. Мазеркина, T. V. Alexandrova, Marina V. Zhuravleva · 2021 · Safety and Risk of Pharmacotherapy
17. Een cardiocerebraal stollingsdilemma bij een oudere patiënte
    D. Jennes, Bernard P. Paelinck, Tomas Menovsky, Greta H. Moorkens, V. MERTENS · 2022 · Tijdschrift voor Geneeskunde
18. Pharmacoepidemiology Research Delivering Evidence About Drug Safety in Older Adults
    Nagham J. Ailabouni, Gizat Molla Kassie, Lisa M. Kalisch Ellett · 2022 · Springer eBooks
19. Pharmacoepidemiology Research Delivering Evidence About Drug Safety in Older Adults
    Nagham J. Ailabouni, Gizat Molla Kassie, Lisa M. Kalisch Ellett · 2023 · Springer eBooks
20. The Value of In-Person Contact in Clinical Trials: A Qualitative Study examining Patient Attitudes towards Trial Visits conducted at a Contract Research Organisation
    Hannah Plaschkes, Hugh N. Furness, Johanna Ulbrich, Ulrike Lorch, Jörg Täubel, Thomas James York · 2024 · Research Square
21. Comparison of Demographics: National Amyotrophic Lateral Sclerosis Registry and Clinical Trials Data
    Moon Han, Jaime S. Raymond, Theodore C. Larson III, Paul Mehta, D. Kevin Horton · 2024 · Journal of Racial and Ethnic Health Disparities
22. Agreement among different fatigue scales in people with extreme longevity and their offsprings: The FACET experience
    Domenico Azzolino, Gabriel Dias Rodrigues, Beatrice Arosio, Tiziano Angelo Lucchi, Nicola Montano, Matteo Cesari · 2024 · Geriatric Nursing
23. Management Strategies for Advancing Rural Elderly Well-Being
    Mayanka Gupta, Deepa Kannur · 2024 · Advances in healthcare information systems and administration book series
24. When older people become sick
    Siri Rostoft · 2025 · Tidsskrift for Den norske legeforening
25. Gleich oder nicht gleich? - Behandlung und Betreuung älterer Menschen in der Anästhesiologie
    Reza Kaviani · 2025 · Springer eBooks
26. Randomised evaluation platform – interventions to treat older people with sarcopenia (REVITALiSE): protocol and description of intervention selection process
    Claire McDonald, Philippa Watts, Helen W Atkinson, Katie Kucukcan, Aritra Mukherjee, Mosammat Polyma, Avan Aihie Sayer, Gemma Spiers, Sarah Khan, Jane Nesworthy et al. · 2025 · medRxiv
27. Clinical and economic burden among older adults with acromegaly in the United States
    Tiffany P. Quock, Eunice Y Chang, Ashis Das, Amanda Speller, Marian H. Tarbox, Stacy K Rattana, Ingrid Paulson, Michael Samuel Broder · 2025 · Journal of Comparative Effectiveness Research
28. Real-world effectiveness and non-inferiority evaluation and comparison of mRNA- and protein-based COVID-19 vaccines: a randomized study protocol (BEEHIVE)
    Sarang K. Yoon, German L. Ellsworth, Steph Battan-Wraith, Andrew L. Phillips, Rebecca V. Fink, Joshua Griffin, Elizabeth A. K. Rowley, Jacob Mckell, Ashley Wilder Smith, Riley Campbell et al. · 2025 · medRxiv
29. SGLT2-remmers en urogenitale infecties bij oudere patiënten
    J Woudstra · 2025 · Geneesmiddelenbulletin
30. Ethical Challenges in Clinical Trials Involving Older Adults in India: A Bioethical and Public Health Perspective
    Jaya Singh Kshatri, Tanveer Rehman, Sushmita Kerketta, Sanghamitra Pati · 2025 · Wellcome Open Research
31. Patients’ perspective on Geriatric Syndromes and their Relation with Quality of Life: a cross-sectional Study
    Aline Schönenberg, Konstantin G. Heimrich, Annika Sternkopf, Paul Lochbihler, Tino Prell · 2025 · Research Square
32. ARDS Studies in Critical Care Journals: How Representative Are the Patients Studied?
    Jennifer Varallo, Tarek Nahle, Peter Galiano, Ricardo Jaime Orozco, Christopher Ambrogi, Adam Green, Jean-Sébastien Rachoin · 2025 · Critical Care Research and Practice
33. The use of NHS databases to identify and manage pharmacotherapy in people with dementia and/or late-life mental disorders
    Harsharon Kaur Sondh, Christoph Mueller, Delia Bishara, Robert J. Stewart · 2025 · Expert Review of Clinical Pharmacology
34. Nurse-led secondary preventive follow-up after stroke/TIA and ACS for patients aged 80 years or older: A post-hoc analysis of the randomized controlled NAILED trial
    Karl Ingard, Anna-Lotta Irewall, Thomas Mooe, Joachim Ögren · 2025 · PLoS ONE
35. CohortSymmetry: An R package to perform sequence symmetry analysis using the OMOP common data model
    Xihang Chen, Ty Stanford, Yuchen Guo, Berta Raventós, Mike Du, Xintong Li, Amy S. M. Lam, George Corby, Núria Mercadé‐Besora, Marta Alcalde‐Herraiz et al. · 2025 · medRxiv
36. Medications for osteoporosis
    Kavin Khatri, Nikhil Gupta, Sameer Aggarwal, Amit Lakhani, Anshul Dahuja, Ankita Kankaria, Abhinav Kanwal · 2025 · Elsevier eBooks
37. Diversity, Equity, and Inclusion in Biomedical Research and Publishing
    Rajshekhar Bipeta · 2025 · Indian Journal of Psychological Medicine
38. Additional file 3 of Clinical trial results in context: comparison of baseline characteristics and outcomes of 38,510 RECOVERY trial participants versus a reference population of 346,271 people hospitalised with COVID-19 in England
    Guilherme Pessoa-Amorim, Goldacre, Raphael, Charles Crichton, Will Stevens, Michelle Nunn, Andy King, Murray, Dave, Welsh, Richard, Heather Pinches, Andrew Rees et al. · 2024 · Figshare
39. Additional file 2 of Clinical trial results in context: comparison of baseline characteristics and outcomes of 38,510 RECOVERY trial participants versus a reference population of 346,271 people hospitalised with COVID-19 in England
    Guilherme Pessoa-Amorim, Goldacre, Raphael, Charles Crichton, Will Stevens, Michelle Nunn, Andy King, Murray, Dave, Welsh, Richard, Heather Pinches, Andrew Rees et al. · 2024 · Figshare
40. Additional file 1 of Clinical trial results in context: comparison of baseline characteristics and outcomes of 38,510 RECOVERY trial participants versus a reference population of 346,271 people hospitalised with COVID-19 in England
    Guilherme Pessoa-Amorim, Goldacre, Raphael, Charles Crichton, Will Stevens, Michelle Nunn, Andy King, Dave Murray, Welsh, Richard, Heather Pinches, Andrew Rees et al. · 2024 · Figshare
41. Additional file 1 of Temporal changes in characteristics and external validity of randomized controlled trials in older people from 2012 to 2019
    Estelle van Eijk, Yanna M. van der Spek, Floor J A van Deudekom, Frederiek van den Bos, Mooijaart, Simon P., Trompet, Stella · 2024 · Figshare
42. Clinical characteristics and drug–drug interactions in human epidermal growth factor receptor 2-positive breast cancer treated with trastuzumab deruxtecan: real-world data from the DE-REAL study
    Simona Pisegna, Simone Scagnoli, Gabriella Gentile, Antonella Chiavassa, Roberta Caputo, Michelino De Laurentiis, Giuseppe Curigliano, Matteo Lambertini, Francesco Pantano, Armando Orlandi et al. · 2026 · The Oncologist
43. Impact of clinical trial virtualization on recruitment in underserved communities for a type 2 diabetes mHealth intervention
    Elizabeth Campbell, Andrea N. Cassells, T.J. Lin, Jacqeline Cortez Lainez, Arlene Merne Smaldone, Pooja Desai, Haomiao Jia, George M. Hripcsak, Jonathan N. Tobin, Lena Mamykina · 2026 · Contemporary Clinical Trials
44. Pooled prevalence of psychological distress and mental health conditions in older adults with inflammatory bowel disease: a protocol for a systematic review and meta-analysis
    Mark Momoh Koroma, Justin Chan, Mielle Michaux, Bwalya Kasanda, Kevan Jacobson · 2026 · Systematic Reviews
45. Robotic Colonic Surgery in Elderly and Octogenarian Patients: Chronological Age Alone Does Not Predict Severe Complications
    Marco Palucci, Igor Monsellato, Irene Gandini, Mariantonietta Alagia, Celeste DEL BASSO, Fabio Giannone, Marco Lodin, Federico Sangiuolo, Gianluca Cassese, Fabrizio Panaro · 2026 · International Journal of Medical Robotics and Computer Assisted Surgery
46. Tumor biology, treatment patterns, and recurrence in breast cancer patients aged 70–79 vs ≥ 80 years: a large-scale registry analysis
    Franziska Ganster, Simone Schrodi, Michael Braun, Ch. Seifert, S. Mahner, T. Kolben, Rachel Wuerstlein, Nadia Harbeck, S Beyer, Maximiliane Burgmann · 2026 · Archives of Gynecology and Obstetrics
47. The views of healthcare professionals and family members on deprescribing preventive medication in people living with dementia: a qualitative systematic review
    Clare Bates, Nikolaos Efstathiou, Claire Sutton, Nesrein Hamed, Ian D. Maidment · 2026 · BMC Geriatrics
48. The Invisible Barrier of Neighborhood Disadvantage in Clinical Trial Recruitment and Retention Among Older Adults
    Raele Donetha Loy, Amy Kind, Nicole M. Rogus‐Pulia · 2026 · Journal of the American Geriatrics Society
49. Participatory Design for Intergenerational Dialogue: How the Voice® Model Can Foster a Longevity Society in the Italian Context
    Camilla Borghi, Beatrice Ferrarini, Valeria Leonardi, Catherine Butcher, Adam Cosheril, Lynne Corner, Nic Palmarini · 2026 · Participatory Design Conference
50. Patterns of care for older multiple myeloma patients in the U.S.: An analysis of the national cancer database
    Muni Rubens, Jeremy I Purow, Daniel M Portnoy, Alejandra Viera Plasencia, Julia Steger, Sofia Steger, Feng Go Ho Wu, Jorge Valdés, Vicente Abreu Fernández, Vicente Antonio Gea Caballero et al. · 2026 · Current Problems in Cancer
51. Effectiveness and safety of avelumab maintenance in patients aged ≥75 years with advanced urothelial cancer: a sub-analysis of the meet-URO 25 (MALVA) study
    Giandomenico Roviello, Elisabetta Gambale, Irene De Gennaro Aquino, Marco Maruzzo, Carlo Messina, Ismaela Anna Vascotto, Virginia Rossi, Davide Bimbatti, Elisa Erbetta, Marco Messina et al. · 2026 · Frontiers in Immunology
52. Safety of SGLT2 inhibitors versus DPP-4 inhibitors in super-elderly patients (≥ 80 years) with type 2 diabetes: a propensity score-matched cohort study
    Shankar Kumar Biswas, Yashasvi Srivastava, Ahmed Wahba, Bushra Amer, Ayman Hamadttu · 2026 · Cardiovascular Diabetology – Endocrinology Reports
53. Experiences of patient-led melanoma surveillance and teledermatology in underserved groups in the Melanoma Self-Surveillance Trial: A qualitative sub-study
    Priti Kharel, Ellie Medcalf, Deonna M. Ackermann, Jake T. W. Williams, Jolyn K. Hersch, Zhuohan Wu, Monika Janda, Dorothy Drabarek, Adrian Fann, Katy Bell · 2026 · Journal of Telemedicine and Telecare
54. Stalled Outcome Gains Despite Treatment Intensification in Stroke Patients Aged 80 and Older: A 12-Year Cohort Study
    Jonguk Kim, Do Yeon Kim, Do Yeon Kim, Nakhoon Kim, Jihoon Kang, Beom Joon Kim, Moon‐Ku Han, Tai Hwan Park, Keon‐Joo Lee, Joon‐Tae Kim et al. · 2026 · medRxiv
55. Using Iterative Concept Testing to Identify Key Considerations for Increasing Research Participation Among Older Racial and Ethnic Minorities Through Social Media Advertising
    Erin K. Maloney, Amy Bleakley, Shawnika J. Hull, Jessica B. S. Langbaum · 2026 · Health Communication
56. Social Pharmacy
    Nhung Nguyen, Nhung Dương, Duy Tran, Nguyen Thi My Hao · 2026 · Springer eBooks
57. Medical cannabis in older adults: real-world evidence from a retrospective observational study
    Carmen S Moreno-Monroy, Iván D Díaz-Moreno, Sofía Maiorana, Noemí López‐Ejeda, Paola Pineda, Cristina Sánchez · 2026 · Research Square
58. Who Is the Older Adult in Primary Care? Rethinking Prevention in Aging Populations Through the XYZ-Tool
    Marie-Pier Villemure, Matthieu Lafontaine-Godbout, Dubé Audrey · 2026 · Advances in Geriatric Medicine and Research
59. Prescribing cascades in frailty
    Hasan Hazim Alsararatee · 2026 · Journal of Prescribing Practice
60. A Multi-Cohort Analysis of Age-Associated Clinical and Transcriptomic Differences in Breast Cancer
    Keyrian Le Gratiet, Sydney Brandt, Armen E. Parsyan, Sarah A. Knowles, Allison Maciver, Maya Grisaru Kacen, Muriel Brackstone, Farhad Ghasemi · 2026 · Current Oncology