The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Refining the ethics of preimplantation genetic diagnosis: A plea for contextualized proportionality
Open accessAbstract
Many European countries uphold a ‘high risk of a serious condition’ requirement for limiting the scope of preimplantation genetic diagnosis (PGD). This ‘front door’ rule should be loosened to account for forms of PGD with a divergent proportionality. This applies to both ‘added PGD’ (aPGD), as an add‐on to in vitro fertilization (IVF), and ‘combination PGD’ (cPGD), for a secondary disorder in addition to the one for which the applicants have an accepted PGD indication. Thus loosening up at the front has implications at the back of PGD treatment, where a further PGD rule says that ‘affected embryos’ (in the sense of embryos with the targeted mutation or abnormality) should not be transferred to the womb. This ‘back door’ rule should be loosened to allow for transferring ‘last chance’ affected embryos in aPGD and cPGD cases, provided this does not entail a high risk that the child will have a seriously diminished quality of life.
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“and may be useful in decisions regarding prenatal treatment with dexamethasone to minimize treatment of male fetuses (see section V.C) (324).”
From Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management (2022) · cites this paper as [324]
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Cites
The Non-Identity Problem and the Ethics of Future People
Boonin, D. (2014) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199682935.001.0001 · Cited by 166
Measuring the welfare of the child: in search of the appropriate evaluation principle
Pennings, G. (1999) · Human Reproduction · doi:10.1093/humrep/14.5.1146 · Cited by 105
Assisted reproductive technologies and equity of access issues
Peterson, M. M. (2005) · Journal of Medical Ethics · doi:10.1136/jme.2003.007542 · Cited by 80
The Post-menopause: Playground for Reproductive Technology? Some Ethical Reflections
de Wert, G. M. W. R. (1998) · doi:10.1093/oso/9780198237617.003.0014 · Cited by 15
Cited by
Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management
Claahsen - van der Grinten, H. L., Speiser, P. W., Ahmed, S. F., Arlt, W., Auchus, R. J., Falhammar, H., Flück, C. E., Guasti, L., Huebner, A., Kortmann, B. B. M., et al. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnab016 · Cited by 556
Preimplantation Genetic Testing for Monogenic Disorders
De Rycke, M., & Berckmoes, V. (2020) · Genes · doi:10.3390/genes11080871 · Cited by 140
Metadata
- Authors
- Dondorp, W., & de Wert, G.
- Affiliations
- Maastricht University (NL)
- Corresponding author
- Dondorp, Wybo
- Venue
- Bioethics
- Publisher
- Wiley
- Published
- 2018-11-26
- Volume
- 33
- Issue
- 2
- Pages
- 294-301
- ISSN
- 0269-9702 (ISSN-L)
- 1467-8519
- PMC
- PMC6587504
- OpenAlex
- W2902643980
- Cited by
- 26
- References
- 4
- Citations by year
- 2026: 2 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 3
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Bioethics (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion, cc-by-nc-nd)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- ZonMw (41111002)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Social Sciences › Law › Medical and Health Sciences Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics and bioethics in healthcare
- Keywords
- preimplantation genetic diagnosis, proportionality, in vitro fertilization, quality of life, reproductive technology regulation
- MeSH terms
- Embryology, Ethics, Medical, Europe, Female, Fertilization in Vitro, Fetal Diseases, Fetus, Genetic Testing, Health Services Accessibility, Humans, Embryo Implantation, Pregnancy, Quality of Life, Comorbidity, Risk Assessment, Preimplantation Diagnosis, Bioethical Issues, Genetic Diseases, Inborn, Early Diagnosis
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
