The DOI matches its Crossref record.
Prevalence of contact allergy in the general population in different European regions
Abstract
BACKGROUND: Population-based studies about contact allergy are scarce. OBJECTIVES: To obtain reliable estimates of the prevalence of contact allergy in the general population in Europe. METHODS: A cross-sectional study of a random sample from the general population, aged 18-74 years, in five different European countries (Sweden, the Netherlands, Germany, Italy and Portugal). In total, 12 377 subjects were interviewed and a random sample (n = 3119) patch tested to TRUE Test panels 1-3 and Fragrance Mix (FM) II, hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) and sesquiterpene lactone mix. A positive patch test reaction is considered as contact allergy. RESULTS: In total, 27·0% [95% confidence interval (CI) 25·5-28·5] had at least one positive reaction to an allergen of the European baseline series, with a significantly higher prevalence in women than in men. The highest age-standardized prevalences (≥ 1%) were found for nickel (14·5%, 95% CI 13·2-15·8), thiomersal (5·0%, 95% CI 4·2-5·8), cobalt (2·2%, 95% CI 1·7-2·7), FM II (1·9%, 95% CI 1·5-2·5), FM I (1·8%, 95% CI 1·4-2·3), HICC (1·4%, 95% CI 1·0-1·9), p-tert-butylphenol formaldehyde resin (1·3%, 95% CI 0·9-1·7) and para-phenylenediamine (1·0%, 95% CI 0·6-1·3). Only nickel and thiomersal showed a statistically significantly different prevalence for contact allergy among the different European populations. Subjects reporting contact dermatitis in their lifetime (age-standardized prevalence 15·1%, 95% CI 13·8-16·3) had an increased risk for contact allergy (odds ratio 1·9, 95% CI 1·5-2·5). The risk of having a contact allergy was not increased in those with atopic dermatitis (prevalence 7·6%, 95% CI 6·7-8·6; odds ratio 1·0, 95% CI 0·7-1·4). CONCLUSIONS: Contact allergy to at least one allergen of the European baseline series was diagnosed in more than one-quarter of the general European population. Therefore measures to improve the primary prevention of contact allergy have to be enforced.
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Citations
Cited by
Prevalence of contact allergy in the general population: A systematic review and meta‐analysis
Alinaghi, F., Bennike, N. H., Egeberg, A., Thyssen, J. P., & Johansen, J. D. (2019) · Contact Dermatitis · doi:10.1111/cod.13119 · Cited by 373
Ahlström, M. G., Thyssen, J. P., Wennervaldt, M., Menné, T., & Johansen, J. D. (2019) · Contact Dermatitis · doi:10.1111/cod.13327 · Cited by 316
Fortino, V., Wisgrill, L., Werner, P., Suomela, S., Linder, N., Jalonen, E., Suomalainen, A., Marwah, V., Kero, M., Pesonen, M., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2009192117 · Cited by 99
Bennike, N. H., Oturai, N. B., Müller, S., Kirkeby, C. S., Jørgensen, C., Christensen, A. B., Zachariae, C., & Johansen, J. D. (2018) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.14513 · Cited by 63
Socioeconomic Status and the Prevalence of Skin and Atopic Diseases in Five European Countries
Ofenloch, R., Schuttelaar, M., Svensson, �., Bruze, M., Naldi, L., Cazzaniga, S., Elsner, P., Gonçalo, M., & Diepgen, T. (2019) · Acta Dermato Venereologica · doi:10.2340/00015555-3082 · Cited by 39
Self-citationThe role of the environment in allergic skin disease
Faraz, K., Seely, M., & Marano, A. L. (2024) · Current Allergy and Asthma Reports · doi:10.1007/s11882-024-01147-9 · Cited by 20
Metadata
- Authors
- Diepgen, T. L., Ofenloch, R. F., Bruze, M., Bertuccio, P., Cazzaniga, S., Coenraads, P.-J., Elsner, P., Goncalo, M., Svensson, Å., & Naldi, L.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-12-26
- Volume
- 174
- Issue
- 2
- Pages
- 319-329
- ISSN
- 0007-0963 (ISSN-L)
- OpenAlex
- W1938177405
- Cited by
- 355
- References
- 0
- FWCI
- 25.57
- Type
- journal article
- Language
- en
- Open access
- closed
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