Cannabidiolic acid prevents vomiting in S uncus murinus and nausea‐induced behaviour in rats by enhancing 5‐HT 1A receptor activation

Bolognini, D; Rock, EM; Cluny, NL; Cascio, MG; Limebeer, CL; Duncan, M; Stott, CG; Javid, FA; Parker, LA; Pertwee, RG

doi:10.1111/bph.12043

Cannabidiolic acid prevents vomiting in S uncus murinus and nausea‐induced behaviour in rats by enhancing 5‐HT 1A receptor activation

Background and Purpose To evaluate the ability of cannabidiolic acid ( CBDA ) to reduce nausea and vomiting and enhance 5‐ HT 1A receptor activation in animal models. Experimental Approach We investigated the effect of CBDA on (i) lithium chloride ( LiCl )‐induced conditioned gaping to a flavour …