Trimetazidine prevents macrophage‐mediated septic myocardial dysfunction via activation of the histone deacetylase sirtuin 1

Chen, Jing; Lai, Jinsheng; Yang, Lei; Ruan, Guoran; Chaugai, Sandip; Ning, Qin; Chen, Chen; Wang, Dao Wen

doi:10.1111/bph.13386

Trimetazidine prevents macrophage‐mediated septic myocardial dysfunction via activation of the histone deacetylase sirtuin 1

Background and Purpose Sepsis is a systemic inflammatory response accompanied by excessive production of inflammatory cytokines and cardiovascular dysfunction. Importantly, macrophage‐derived pro‐inflammatory agents play a key role in cardiovascular impairment in sepsis. Here we have investigated…