The DOI matches its Crossref record; 226 of the 226 references it cites were found in a registry or an index.
The potential health effects of dietary phytoestrogens
Open accessAbstract
Phytoestrogens are plant‐derived dietary compounds with structural similarity to 17‐β‐oestradiol (E2), the primary female sex hormone. This structural similarity to E2 enables phytoestrogens to cause (anti)oestrogenic effects by binding to the oestrogen receptors. The aim of the present review is to present a state‐of‐the‐art overview of the potential health effects of dietary phytoestrogens. Various beneficial health effects have been ascribed to phytoestrogens, such as a lowered risk of menopausal symptoms like hot flushes and osteoporosis, lowered risks of cardiovascular disease, obesity, metabolic syndrome and type 2 diabetes, brain function disorders, breast cancer, prostate cancer, bowel cancer and other cancers. In contrast to these beneficial health claims, the (anti)oestrogenic properties of phytoestrogens have also raised concerns since they might act as endocrine disruptors, indicating a potential to cause adverse health effects. The literature overview presented in this paper illustrates that several potential health benefits of phytoestrogens have been reported but that, given the data on potential adverse health effects, the current evidence on these beneficial health effects is not so obvious that they clearly outweigh the possible health risks. Furthermore, the data currently available are not sufficient to support a more refined (semi) quantitative risk–benefit analysis. This implies that a definite conclusion on possible beneficial health effects of phytoestrogens cannot be made. Linked Articles: This article is part of a themed section on Principles of Pharmacological Research of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.11/issuetoc
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Items 201–226 of 226
Zhao, L., Mao, Z., Schneider, L. S., & Brinton, R. D. (2011) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3182175b66 · Cited by 41
Use of isoflavone supplements is associated with reduced postmenopausal breast cancer risk
Boucher, B. A., Cotterchio, M., Anderson, L. N., Kreiger, N., Kirsh, V. A., & Thompson, L. U. (2013) · International Journal of Cancer · doi:10.1002/ijc.27769 · Cited by 40
Phytoestrogen Intake and Risk of Ovarian Cancer: a Meta-Analysis of 10 Observational Studies
Qu, X., Fang, Y., Zhang, M., & Zhang, Y. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.21.9085 · Cited by 38
Impact of estrogen receptor alpha and beta agonists on delayed alternation in middle-aged rats
Neese, S. L., Korol, D. L., Katzenellenbogen, J. A., & Schantz, S. L. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.08.017 · Cited by 37
Colacurci, N., FRANCISCIS, P. D., Atlante, M., Mancino, P., Monti, M., Volpini, G., & Benvenuti, C. (2012) · Gynecological Endocrinology · doi:10.3109/09513590.2012.738724 · Cited by 37
Boué, S. M., Burow, M. E., Wiese, T. E., Shih, B. Y., Elliott, S. G., Carter‐Wientjes, C. H., McLachlan, J. A., & Bhatnagar, D. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf102255u · Cited by 37
Sesaminol Glucosides Protect .BETA.-Amyloid Peptide-Induced Cognitive Deficits in Mice
Um, M. Y., Ahn, J. Y., Kim, S., Kim, M. K., & Ha, T. Y. (2009) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.32.1516 · Cited by 36
Morán, J., Garrido, P., Alonso, A., Cabello, E., & González, C. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.02.010 · Cited by 34
Soybean Supplementation Helps Reverse Age- and Scopolamine-Induced Memory Deficits in Mice
Bansal, N., & Parle, M. (2010) · Journal of Medicinal Food · doi:10.1089/jmf.2010.1132 · Cited by 31
Beekmann, K., de Haan, L. H. J., Actis‐Goretta, L., Houtman, R., van BLADEREN, P. J., & Rietjens, I. M. C. M. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.09.002 · Cited by 30
Self-citationStruja, T., Richard, A., Linseisen, J., Eichholzer, M., & Rohrmann, S. (2013) · European Journal of Nutrition · doi:10.1007/s00394-013-0639-y · Cited by 30
(2008) · PubMed · Cited by 30
EFSA Panel on Dietetic Products, N. A. A. (. (2012) · EFSA Journal · doi:10.2903/j.efsa.2012.2847 · Cited by 29
[Soya isoflavones and evidences on cardiovascular protection].
Cañete, N. G., & Durán‐Agüero, S. (2014) · PubMed · doi:10.3305/nh.2014.29.6.7047 · Cited by 27
Risk Assessment of Soybean-Based Phytoestrogens
Kwack, S. J., Kim, K., Kim, H. S., Yoon, K. S., & Lee, B. M. (2009) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390903212212 · Cited by 27
Molzberger, A. F., Soukup, S. T., Kulling, S. E., & Diel, P. R. (2013) · Archives of Toxicology · doi:10.1007/s00204-012-1009-x · Cited by 24
Wang, S., Aarts, J. M. M. J. G., Evers, N. M., Peijnenburg, A., Rietjens, I. M. C. M., & Bovee, T. F. H. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.11.009 · Cited by 24
Self-citationTiosano, D., Paris, F., Grimaldi, M., Georgescu, V., Servant, N., Hochberg, Z., Balaguer, P., & Sultan, C. (2014) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-12-97 · Cited by 23
Evers, N. M., van den Berg, J. H. J., Wang, S., Melchers, D., Houtman, R., de Haan, L. H. J., EDERVEEN, A. G. H., Groten, J. P., & Rietjens, I. M. C. M. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.06.002 · Cited by 20
Self-citationObesity: epigenetic regulation – recent observations
Remely, M., de la Garza, A. L., Magnet, U., Aumueller, E., & Haslberger, A. G. (2015) · BioMolecular Concepts · doi:10.1515/bmc-2015-0009 · Cited by 20
Do Estrogen Receptor β Polymorphisms Play A Role in the Pharmacogenetics of Estrogen Signaling?
Nott, S. L., Huang, Y., Fluharty, B. R., Sokolov, A., Huang, M., Cox, C. R., & Muyan, M. (2008) · Current pharmacogenomics and personalized medicine (Online)/Current pharmacogenomics and personalized medicine · doi:10.2174/187569208786733820 · Cited by 19
Plant extracts for the treatment of menopausal women: Safe?
Wuttke, W., Rimoldi, G., Christoffel, J., & Seidlová‐Wuttke, D. (2006) · Maturitas · doi:10.1016/j.maturitas.2006.06.021 · Cited by 14
Messina, M. J. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200890007 · Cited by 13
Evers, N. M., Wang, S., van den Berg, J. H. J., Houtman, R., Melchers, D., de Haan, L. H. J., EDERVEEN, A. G. H., Groten, J. P., & Rietjens, I. M. C. M. (2014) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2014.06.019 · Cited by 10
Self-citationIn search of estrogen alternatives for the brain
Zhao, L., & Brinton, R. D. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511635700.011 · Cited by 8
Benefits and Risks of Phytoestrogens
Karahalıl, B. (2005) · CRC Press eBooks · doi:10.1201/9781420027594.ch8 · Cited by 3
Cited by
The effects of vegetarian and vegan diets on gut microbiota
Tomova, A., Bukovsky, I., Rembert, E., Yonas, W., Alwarith, J., Barnard, N. D., & Kahleova, H. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00047 · Cited by 713
Gut microbial molecules in behavioural and neurodegenerative conditions
Needham, B. D., Kaddurah-Daouk, R., & Mazmanian, S. K. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-00381-0 · Cited by 379
You’ve got male: Sex and the microbiota-gut-brain axis across the lifespan
Jaggar, M., Rea, K., Spichak, S., Dinan, T. G., & Cryan, J. F. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100815 · Cited by 200
The "Gut Feeling": Breaking Down the Role of Gut Microbiome in Multiple Sclerosis
Freedman, S. N., Shahi, S. K., & Mangalam, A. K. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0588-x · Cited by 168
Functional components of peanuts (Arachis Hypogaea L.) and health benefits: A review
Çiftçi, S., & Suna, G. (2022) · Future Foods · doi:10.1016/j.fufo.2022.100140 · Cited by 126
Metadata
- Authors
- Rietjens, I. M. C. M., Louisse, J., & Beekmann, K.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2016-10-20
- Volume
- 174
- Issue
- 11
- Pages
- 1263-1280
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W2531867361
- Cited by
- 490
- References
- 226
- FWCI
- 29.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
